Results 11 to 20 of about 1,151,716 (261)
RNA-Binding Proteins in Cardiomyopathies
Journal of Cardiovascular Development and DiseaseThe post-transcriptional regulation of gene expression plays an important role in heart development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding proteins, orchestrates the isoform switching of proteins that are essential ...
De-Li Shi
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Survey of the binding preferences of RNA-binding proteins to RNA editing events
Genome Biology, 2022 Background Adenosine-to-inosine (A-to-I) editing is an important RNA posttranscriptional process related to a multitude of cellular and molecular activities.
Xiaolin Hu, Qin Zou, Li Yao, Xuerui Yang
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RNA-Binding Proteins in Dinoflagellates. [PDF]
Int J Mol SciThe described features of dinoflagellate gene expression indicate the predominance of post-transcriptional and translational regulation over transcriptional control. These microorganisms also exhibit extensive RNA editing and distinctive splicing characteristics.
Berdieva M, Safonov P, Skarlato S.
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RNA‐PROTACs: Degraders of RNA‐Binding Proteins [PDF]
Angewandte Chemie International Edition, 2020 AbstractDefects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases; however, targeting RBPs with conventional drugs has proven difficult. PROTACs are a new class of drugs that mediate selective degradation of a target protein through a cell's ubiquitination machinery.
Alice Ghidini +4 more
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WormBook, 2006 The C. elegans genome encodes many RNA-binding proteins (RBPs) with diverse functions in development, indicative of extensive layers of post-transcriptional control of RNA metabolism. A number of C. elegans RBPs have been identified by forward or reverse genetics. They tend to display tissue-specific mutant phenotypes, which underscore their functional
Lee, Min'Ho, Schedl, Tim
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γ-AApeptides bind to RNA by mimicking RNA-binding proteins [PDF]
Organic & Biomolecular Chemistry, 2011 The interactions between proteins and RNAs are of vital importance for many cellular processes, including transcription and processing of RNA, translation, and viral infections. Here we report an γ-AApeptide that can mimic HIV-1 Tat protein and bind to TAR RNAs of HIV and BIV with nanomolar affinity, comparable to that of the RNA-binding fragment of ...
Youhong, Niu +4 more
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RNA-Binding Profiles of CKAP4 as an RNA-Binding Protein in Myocardial Tissues [PDF]
Frontiers in Cardiovascular Medicine, 2021 Background: Pathological tissue remodeling such as fibrosis is developed in various cardiac diseases. As one of cardiac activated-myofibroblast protein markers, CKAP4 may be involved in this process and the mechanisms have not been explored.Methods: We assumed that CKAP4 held a role in the regulation of cardiac fibrotic remodeling as an RNA-binding ...
Hong Zhu +7 more
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RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific
Scientific Reports, 2023 Thousands of RNA-binding proteins (RBPs) crosslink to cellular mRNA. Among these are numerous unconventional RBPs (ucRBPs)—proteins that associate with RNA but lack known RNA-binding domains (RBDs).
Debashish Ray +17 more
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Identification of RNA-binding Proteins
Bio-Protocol, 2016 This protocol describes the extraction of RNA-binding proteins (RBPs) from cell lysates. In order to pull down target RBPs, 5-bromo-UTP (BrUTP)-incorporated RNA probes are used, which are generated by in vitro transcription.
Kazuya Masuda, Tadamitsu Kishimoto
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The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
Frontiers in Oncology, 2021 The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs.
Zhigang Li +6 more
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