Results 11 to 20 of about 1,182,184 (311)
WormBook, 2006 The C. elegans genome encodes many RNA-binding proteins (RBPs) with diverse functions in development, indicative of extensive layers of post-transcriptional control of RNA metabolism. A number of C. elegans RBPs have been identified by forward or reverse genetics. They tend to display tissue-specific mutant phenotypes, which underscore their functional
Lee, Min'Ho, Schedl, Tim
openaire +3 more sources
γ-AApeptides bind to RNA by mimicking RNA-binding proteins [PDF]
Organic & Biomolecular Chemistry, 2011 The interactions between proteins and RNAs are of vital importance for many cellular processes, including transcription and processing of RNA, translation, and viral infections. Here we report an γ-AApeptide that can mimic HIV-1 Tat protein and bind to TAR RNAs of HIV and BIV with nanomolar affinity, comparable to that of the RNA-binding fragment of ...
Youhong, Niu +4 more
openaire +2 more sources
RNA binding proteins in MLL-rearranged leukemia
Experimental Hematology & Oncology, 2022 RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene expression regulators in both normal development and disease.
Tiffany M. Tran, Dinesh S. Rao
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 Core spliceosome and related RNA-binding proteins aggregate in Alzheimer’s disease (AD) brain even in early asymptomatic stages (AsymAD) of disease.
Qi Guo +15 more
doaj +1 more source
The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation
eLife, 2021 TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its structured N-terminal and intrinsically disordered C-terminal domains has ...
Juan Carlos Rengifo-Gonzalez +8 more
doaj +1 more source
RNA-Binding Profiles of CKAP4 as an RNA-Binding Protein in Myocardial Tissues [PDF]
Frontiers in Cardiovascular Medicine, 2021 Background: Pathological tissue remodeling such as fibrosis is developed in various cardiac diseases. As one of cardiac activated-myofibroblast protein markers, CKAP4 may be involved in this process and the mechanisms have not been explored.Methods: We assumed that CKAP4 held a role in the regulation of cardiac fibrotic remodeling as an RNA-binding ...
Hong Zhu +7 more
openaire +3 more sources
Classifying RNA-binding proteins based on electrostatic properties. [PDF]
PLoS Computational Biology, 2008 Protein structure can provide new insight into the biological function of a protein and can enable the design of better experiments to learn its biological roles.
Shula Shazman, Yael Mandel-Gutfreund
doaj +1 more source
RNA-binding proteins in tumor progression
Journal of Hematology & Oncology, 2020 RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling the processing and transportation of RNA ...
Hai Qin +6 more
doaj +1 more source
RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific
Scientific Reports, 2023 Thousands of RNA-binding proteins (RBPs) crosslink to cellular mRNA. Among these are numerous unconventional RBPs (ucRBPs)—proteins that associate with RNA but lack known RNA-binding domains (RBDs).
Debashish Ray +17 more
doaj +1 more source
Trim25 is an RNA-specific activator of Lin28a/TuT4-mediated uridylation [PDF]
, 2014 RNA binding proteins have thousands of cellular RNA targets and often exhibit opposite or passive molecular functions. Lin28a is a conserved RNA binding protein involved in pluripotency and tumorigenesis that was previously shown to trigger TuT4-mediated
Nowak, Jakub S. +14 more
core +1 more source