Results 11 to 20 of about 3,122,867 (388)

Guardian of Genetic Messenger-RNA-Binding Proteins [PDF]

Biomolecules, 2016
RNA in cells is always associated with RNA-binding proteins that regulate all aspects of RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA turn-over as well as translation. Given their diverse functions, cells express
Antje Anji, Meena Kumari
doaj   +7 more sources

RNA binding proteins in osteoarthritis

Frontiers in Cell and Developmental Biology, 2022
Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The pathological features of OA are the erosion of articular cartilage, subchondral bone sclerosis, synovitis, and metabolic disorder.
Qian Yi, Qian Yi, Qian Yi, Zhenhan Deng, Jiaji Yue, Jinglong He, Jianyi Xiong, Wei Sun, Weichao Sun, Weichao Sun   +9 more
doaj   +3 more sources

RNA-binding proteins [PDF]

WormBook, 2006
The C. elegans genome encodes many RNA-binding proteins (RBPs) with diverse functions in development, indicative of extensive layers of post-transcriptional control of RNA metabolism. A number of C. elegans RBPs have been identified by forward or reverse
Lee, Min\u27Ho, Schedl, Tim
core   +6 more sources

RNA-binding proteins in tumor progression

Journal of Hematology & Oncology, 2020
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling the processing and transportation of RNA ...
Hai Qin, Haiwei Ni, Yichen Liu, Yaqin Yuan, Tao Xi, Xiaoman Li, Lufeng Zheng   +6 more
doaj   +2 more sources

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins.

Cell, 2018
Proteins such as FUS phase separate to form liquid-like condensates that can harden into less dynamic structures. However, how these properties emerge from the collective interactions of many amino acids remains largely unknown.
Jie Wang, Jeong-Mo Choi, A. Holehouse, Hyun O Lee, Xiaojie Zhang, Marcus Jahnel, Shovamayee Maharana, Régis P. Lemaitre, Andrei Pozniakovsky, D. Drechsel, I. Poser, R. Pappu, S. Alberti, A. Hyman   +13 more
semanticscholar   +3 more sources

A large-scale binding and functional map of human RNA-binding proteins

Nature, 2020
Many proteins regulate the expression of genes by binding to specific regions encoded in the genome1. Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part of the ...
Eric L. Van Nostrand, Peter Freese, G. Pratt, Xiaofeng Wang, Xintao Wei, Rui Xiao, S. Blue, Daniel Dominguez, Neal A. L. Cody, S. Olson, B. Sundararaman, L. Zhan, C. Bazile, Louis Philip Benoit Bouvrette, Jia-Yu Chen, M. Duff, Keri E. Garcia, C. Gelboin-Burkhart, Abigail Hochman, Nicole J. Lambert, Hai-Ri Li, Thai Nguyen, T. Palden, Ines Rabano, S. Sathe, Rebecca Stanton, Julie Bergalet, Bing Zhou, Amanda Su, Ruth Wang, Brian A. Yee, Ashley L. Louie, S. Aigner, Xiang-Dong Fu, E. Lécuyer, C. Burge, B. Graveley, Gene W. Yeo   +37 more
semanticscholar   +3 more sources

RNA-Binding Proteins in Cardiomyopathies

Journal of Cardiovascular Development and Disease
The post-transcriptional regulation of gene expression plays an important role in heart development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding proteins, orchestrates the isoform switching of proteins that are essential ...
De-Li Shi
doaj   +4 more sources

RNA-Binding Proteins in Dinoflagellates. [PDF]

Int J Mol Sci
The described features of dinoflagellate gene expression indicate the predominance of post-transcriptional and translational regulation over transcriptional control.
Berdieva M, Safonov P, Skarlato S.
europepmc   +2 more sources

RNA‐PROTACs: Degraders of RNA‐Binding Proteins [PDF]

Angewandte Chemie International Edition, 2020
Defects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases; however, targeting RBPs with conventional drugs has proven difficult.
A. Ghidini, A. Cléry, François Halloy, F. Allain, Jonathan Hall   +4 more
semanticscholar   +5 more sources

The RNA Binding Specificity of Human APOBEC3 Proteins Resembles That of HIV-1 Nucleocapsid. [PDF]

PLoS Pathogens, 2016
The APOBEC3 (A3) cytidine deaminases are antiretroviral proteins, whose targets include human immunodeficiency virus type-1 (HIV-1). Their incorporation into viral particles is critical for antiviral activity and is driven by interactions with the RNA ...
Ashley York, Sebla B Kutluay, Manel Errando, Paul D Bieniasz   +3 more
doaj   +5 more sources