Results 41 to 50 of about 1,182,184 (311)
RNA‐binding proteins and RNA methylation in myeloid cells
Immunological Reviews, 2021 AbstractRNA‐binding proteins (RBPs) regulate all aspects of the life of mRNA transcripts. They are critically important in regulating immune responses, most notably by restraining excessive inflammation that can potentially lead to tissue damage.
Marian Bataclan +2 more
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Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes
eLife, 2023 Fusion of multivesicular bodies (MVBs) with the plasma membrane results in the secretion of intraluminal vesicles (ILVs), or exosomes. The sorting of one exosomal cargo RNA, miR223, is facilitated by the RNA-binding protein, YBX1 (Shurtleff et al., 2016).
Liang Ma, Jasleen Singh, Randy Schekman
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Mechanism of RNA recognition by a Musashi RNA-binding protein [PDF]
Current Research in Structural Biology, 2020 Abstract The Musashi RNA-binding proteins (RBPs) regulate translation of target mRNAs and maintenance of cell stemness and tumorigenesis. Musashi-1 (MSI1), long considered as an intestinal and neural stem cell marker, has been more recently found to be overexpressed in many cancers. It has served as an important drug target for treating
Jinan Wang +4 more
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The functions of y-box binding proteins in caenorhabditis elegans [PDF]
, 2015 Members of the highly conserved family of Y-box binding proteins (YBPs) have a broad spectrum of functions in both transcriptional and post-transcriptional regulation of gene expression.
Arnold, Andreas
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Chloroplast RNA-binding proteins [PDF]
Current Genetics, 2003 Chloroplast gene expression is regulated by nucleus-encoded factors, which mainly act at the post-transcriptional level. Plastid RNA-binding proteins (RBPs) represent good candidates for mediating these functions. The picture emerging from recent analyses is that of a great number of differentially regulated RBPs, which are organized in distinct ...
openaire +2 more sources
Single molecule probing of disordered RNA binding proteins
STAR Protocols, 2022 Summary: Liquid-liquid phase separation of intrinsically disordered proteins is known to underlie diverse pathologies such as neurodegeneration, cancer, and aging.
Kevin Rhine, Sua Myong
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RNA-specific ribonucleotidyl transferases [PDF]
, 2007 RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W. +3 more
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Beyond RNA-binding domains: determinants of protein–RNA binding
RNARNA-binding proteins (RBPs) are composed of RNA-binding domains (RBDs) often linked via intrinsically disordered regions (IDRs). Structural and biochemical analyses have shown that disordered linkers contribute to RNA binding by orienting the adjacent RBDs and also characterized certain disordered repeats that directly contact the RNA.
Zigdon, Inbal +5 more
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Advances in the characterization of RNA‐binding proteins
WIREs RNA, 2016 From transcription, to transport, storage, and translation, RNA depends on association with different RNA‐binding proteins (RBPs). Methods based on next‐generation sequencing and protein mass‐spectrometry have started to unveil genome‐wide interactions of RBPs but many aspects still remain out of sight.
Marchese, Domenica +4 more
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AU-rich RNA binding proteins in hematopoiesis and leukemogenesis
, 2011 Posttranscriptional mechanisms are now widely acknowledged to play a central role in orchestrating gene-regulatory networks in hematopoietic cell growth, differentiation, and tumorigenesis.
Baou, M. +5 more
core +1 more source