Results 41 to 50 of about 4,565,908 (262)

Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules [PDF]

, 2010
The tospovirus NSs protein was previously shown to suppress the antiviral RNA silencing mechanism in plants. Here the biochemical analysis of NSs proteins from different tospoviruses, using purified NSs or NSs containing cell extracts, is described.
Kormelink, R.J.M., Rik Huismann, Esther Schnettler, Rob Goldbach, Goldbach, R., Marcel Prins, Goldbach, R.W., Kormelink, R., Hemmes, H., Prins, M., Huismann, R., Hans Hemmes, Huisman, R., Hemmes, J.C., Schnettler, E., Richard Kormelink, Prins, M.W.   +16 more
core   +1 more source

Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling

Nature Communications
ADP-ribosylation has long been recognised as a key regulator of essential signalling pathways, including the DNA damage response. However, only recent and ongoing technological advances are beginning to make it possible to investigate its distinct forms ...
Helen Dauben, Mihaela Mihaljević, Andreas Kolvenbach, Maria Dilia Palumbieri, Chrysi Kapsali, Ina Huppertz, Ivan Matić   +6 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Transition of plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein pumilio [PDF]

, 2011
Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs.
Gunnar R Mair, Waters, Andrew, Waters, A.P., Prudêncio, M., Joanna Braks, Braks, Joanna, Mair Gunnar R., Braks, J., Theresa Feltwell, Prudêncio, Miguel, Mair, Gunnar R., Gomes-Santos, Carina S. S., Feltwell Theresa, Pain, A., Janse, C., Mota, Maria M., Mota, M.M., Céline Carret, Carret, Céline, Shahid Khan, Gomes, Ana Rita, Khan, S., Miguel Prudêncio, Ana Rita Gomes, Carina S S Gomes-Santos, Mota Maria M., Khan Shahid, Carina S. S. Gomes-Santos, Prudêncio Miguel, Maria M. Mota, Waters Andrew, Gomes-Santos Carina S. S., Gomes-Santos, C.S.S., Gomes, A.R., Mair, G.R., Andrew Waters, Gunnar R. Mair, Gomes Ana Rita, Feltwell, T., Carret Céline, Pain, Arnab, Khan, Shahid, Janse, Chris, Chris Janse, Maria M Mota, Carret, C., Janse Chris, Waters, A., Arnab Pain, Pain Arnab, Feltwell, Theresa, Braks Joanna   +51 more
core   +1 more source

Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction [PDF]

, 2012
This work was supported by the Wellcome Trust (grant AL087751/B)RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD ...
Childs, Kay, Randall, Richard, Goodbourn, Stephen, Randall, Richard; id_orcid   +3 more
core   +2 more sources

RNA-binding proteins in bone pathophysiology

Frontiers in Cell and Developmental Biology
Bone remodelling is a highly regulated process that maintains mineral homeostasis and preserves bone integrity. During this process, intricate communication among all bone cells is required.
Paola Maroni, Noemi Anna Pesce, Giovanni Lombardi, Giovanni Lombardi   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

RNA-Binding Proteins: Splicing Factors and Disease

Biomolecules, 2015
Pre-mRNA splicing is mediated by interactions of the Core Spliceosome and an array of accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory component in higher eukaryotes.
Alger M. Fredericks, Kamil J. Cygan, Brian A. Brown, William G. Fairbrother   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The role of TNRC6 proteins in gene silencing [PDF]

, 2013
Proteins of the GW182 family have recently emerged as key players in miRNAmediated gene silencing. They have been shown to interact with Argonaute proteins, components of the RISC and are assumed to mediate the repression in metazoa. Three paralogues are
Zipprich, Jakob Theophil
core   +1 more source