Results 51 to 60 of about 1,182,184 (311)
Transition of plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein pumilio [PDF]
, 2011 Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs.
Gunnar R Mair +51 more
core +1 more source
Nature CommunicationsADP-ribosylation has long been recognised as a key regulator of essential signalling pathways, including the DNA damage response. However, only recent and ongoing technological advances are beginning to make it possible to investigate its distinct forms ...
Helen Dauben +6 more
doaj +1 more source
RNA-Binding Proteins: Splicing Factors and Disease
Biomolecules, 2015 Pre-mRNA splicing is mediated by interactions of the Core Spliceosome and an array of accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory component in higher eukaryotes.
Alger M. Fredericks +3 more
doaj +1 more source
Alternative polyadenylation and RNA-binding proteins [PDF]
Journal of Molecular Endocrinology, 2016 Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3′-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and ...
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The cold-inducible RNA-binding motif protein 3 (RBM3) prevents cell death through various mechanisms [PDF]
, 2016 Moderate hypothermia promotes the survival of neural cells in a wide range of brain disorders. During hypothermia, a subgroup of proteins including two homologues, RNA-binding motif protein 3 (RBM3) and cold-inducible RNA-binding protein (CIRP), is ...
Zhu, Xinzhou
core +1 more source
RNA-binding proteins in bone pathophysiology
Frontiers in Cell and Developmental BiologyBone remodelling is a highly regulated process that maintains mineral homeostasis and preserves bone integrity. During this process, intricate communication among all bone cells is required.
Paola Maroni +3 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Functional Advantages of Conserved Intrinsic Disorder in RNA-Binding Proteins. [PDF]
PLoS ONE, 2015 Proteins form large macromolecular assemblies with RNA that govern essential molecular processes. RNA-binding proteins have often been associated with conformational flexibility, yet the extent and functional implications of their intrinsic disorder have
Mihaly Varadi +3 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Background: The dysregulation of RNA binding proteins (RBPs) is involved in tumorigenesis and progression. However, information on the overall function of RNA binding proteins in Uterine Corpus Endometrial Carcinoma (UCEC) remains to be studied.
Yong Yao +20 more
doaj +1 more source