Geneticin reduces mRNA stability.
PLoS ONE, 2022 Messenger RNA (mRNA) translation can lead to higher rates of mRNA decay, suggesting the ribosome plays a role in mRNA destruction. Furthermore, mRNA features, such as codon identities, which are directly probed by the ribosome, correlate with mRNA decay ...
Yavuz T Durmaz +2 more
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Nanobiotechnology-Enabled mRNA Stabilization
Pharmaceutics, 2023 mRNA technology has attracted enormous interest due to its great therapeutic potential. Strategies that can stabilize fragile mRNA molecules are crucial for their widespread applications.
He Xian +3 more
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The decapping activator Edc3 and the Q/N-rich domain of Lsm4 function together to enhance mRNA stability and alter mRNA decay pathway dependence in Saccharomyces cerevisiae [PDF]
Biology Open, 2016 The rate and regulation of mRNA decay are major elements in the proper control of gene expression. Edc3 and Lsm4 are two decapping activator proteins that have previously been shown to function in the assembly of RNA granules termed P bodies.
Susanne Huch +5 more
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Attenuated Codon Optimality Contributes to Neural-Specific mRNA Decay in Drosophila [PDF]
Cell Reports, 2018 Summary: Tissue-specific mRNA stability is important for cell fate and physiology, but the mechanisms involved are not fully understood. We found that zygotic mRNA stability in Drosophila correlates with codon content: optimal codons are enriched in ...
Dana A. Burow +5 more
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Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease [PDF]
Nature Communications, 2017 “mRNA abundance is determined by the rates of transcription and decay. Here, the authors propose a method for estimating the rate of differential mRNA decay from RNA-seq data and model mRNA stability in the brain, suggesting a link between mRNA stability
Rached Alkallas +3 more
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Genetic variants associated mRNA stability in lung [PDF]
BMC Genomics, 2022 Background Expression quantitative trait loci (eQTLs) analyses have been widely used to identify genetic variants associated with gene expression levels to understand what molecular mechanisms underlie genetic traits. The resultant eQTLs might affect the
Jian-Rong Li +4 more
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TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability [PDF]
The EMBO JournalThe subcellular localization of many mRNAs to neuronal projections allows neurons to efficiently and rapidly react to spatially restricted external cues. However, for most of these RNAs, the mechanisms that govern their localization are unknown.
Charlie Moffatt +9 more
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Role of mRNA stability during bacterial adaptation. [PDF]
PLoS ONE, 2013 Bacterial adaptation involves extensive cellular reorganization. In particular, growth rate adjustments are associated with substantial modifications of gene expression and mRNA abundance.
Clémentine Dressaire +6 more
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Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery
Pharmaceutics, 2023 Directly injecting naked or lipid nanoparticle (LNP)-encapsulated modified mRNA (modRNA) allows rapid and efficient protein expression. This non-viral technology has been used successfully in modRNA vaccines against SARS-CoV-2.
Magdalena M. Żak +7 more
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Research Advances on the Stability of mRNA Vaccines
Viruses, 2023 Compared to other vaccines, the inherent properties of messenger RNA (mRNA) vaccines and their interaction with lipid nanoparticles make them considerably unstable throughout their life cycles, impacting their effectiveness and global accessibility.
Feiran Cheng +7 more
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