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Research Advances on the Stability of mRNA Vaccines
Viruses, 2023 Compared to other vaccines, the inherent properties of messenger RNA (mRNA) vaccines and their interaction with lipid nanoparticles make them considerably unstable throughout their life cycles, impacting their effectiveness and global accessibility.
Feiran Cheng +7 more
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Nanobiotechnology-Enabled mRNA Stabilization
Pharmaceutics, 2023 mRNA technology has attracted enormous interest due to its great therapeutic potential. Strategies that can stabilize fragile mRNA molecules are crucial for their widespread applications.
He Xian +3 more
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Geneticin reduces mRNA stability.
PLoS ONE, 2022 Messenger RNA (mRNA) translation can lead to higher rates of mRNA decay, suggesting the ribosome plays a role in mRNA destruction. Furthermore, mRNA features, such as codon identities, which are directly probed by the ribosome, correlate with mRNA decay ...
Yavuz T Durmaz +2 more
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Pharmaceutics, 2022 The vaccine distribution chains in several low- and middle-income countries are not adequate to facilitate the rapid delivery of high volumes of thermosensitive COVID-19 mRNA vaccines at the required low and ultra-low temperatures. COVID-19 mRNA vaccines
Zoltán Kis
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Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery
Pharmaceutics, 2023 Directly injecting naked or lipid nanoparticle (LNP)-encapsulated modified mRNA (modRNA) allows rapid and efficient protein expression. This non-viral technology has been used successfully in modRNA vaccines against SARS-CoV-2.
Magdalena M. Żak +7 more
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mRNA stability in the nucleus [PDF]
Journal of Zhejiang University SCIENCE B, 2014 Eukaryotic gene expression is controlled by different levels of biological events, such as transcription factors regulating the timing and strength of transcripts production, alteration of transcription rate by RNA processing, and mRNA stability during RNA processing and translation. RNAs, especially mRNAs, are relatively vulnerable molecules in living
Han, Liu, Min, Luo, Ji-kai, Wen
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Biology Open, 2020 During Drosophila and vertebrate brain development, the conserved transcription factor Prospero/Prox1 is an important regulator of the transition between proliferation and differentiation.
Tamsin J. Samuels +9 more
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Stability of mRNA/DNA and DNA/DNA duplexes affects mRNA transcription. [PDF]
PLoS ONE, 2007 Nucleic acids, due to their structural and chemical properties, can form double-stranded secondary structures that assist the transfer of genetic information and can modulate gene expression.
Rayna I Kraeva +5 more
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PABPC1——mRNA stability, protein translation and tumorigenesis
Frontiers in Oncology, 2022 Mammalian poly A-binding proteins (PABPs) are highly conserved multifunctional RNA-binding proteins primarily involved in the regulation of mRNA translation and stability, of which PABPC1 is considered a central regulator of cytoplasmic mRNA homing and ...
Ya Qi, Min Wang, Qi Jiang
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An mRNA Stability Complex Functions with Poly(A)-Binding Protein To Stabilize mRNA In Vitro [PDF]
Molecular and Cellular Biology, 1999 The stable globin mRNAs provide an ideal system for studying the mechanism governing mammalian mRNA turnover. alpha-Globin mRNA stability is dictated by sequences in the 3' untranslated region (3'UTR) which form a specific ribonucleoprotein complex (alpha-complex) whose presence correlates with mRNA stability. One of the major protein components within
Z, Wang +3 more
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