Systematic discovery of structural elements governing stability of mammalian messenger RNAs. [PDF]
, 2012 Decoding post-transcriptional regulatory programs in RNA is a critical step towards the larger goal of developing predictive dynamical models of cellular behaviour.
Cristea, Ileana M +7 more
core +2 more sources
Tristetraprolin Regulates CXCL1 (KC) mRNA Stability [PDF]
The Journal of Immunology, 2008 Abstract mRNAs encoding proinflammatory chemokines are regulated posttranscriptionally via adenine-uridine-rich sequences (AREs) located in the 3′ untranslated region of the message, which are recognized by sequence-specific RNA-binding proteins.
Shyamasree, Datta +6 more
openaire +2 more sources
RNA-Binding protein HuR and the members of miR-200 family play an unconventional role in the regulation of c-Jun mRNA [PDF]
, 2016 Post-transcriptional gene regulation is a fundamental step for coordinating cellular response in a variety of processes. RNA-binding proteins (RBPs) and microRNAs (miRNAs) are the most important factors responsible for this regulation.
BOZZONI, Irene +6 more
core +1 more source
Signaling control of SOS1 mRNA stability [PDF]
Plant Signaling & Behavior, 2008 Regulation of mRNA decay rates appears to be an important control point in determining the abundance of gene transcripts. Rapid change in decay rates of mRNAs could provide prompt responses of the plants to environmental fluctuations. SOS1 is a plasma-membrane Na(+)/H(+) antiporter crucial for salt tolerance in Arabidopsis.
Jiafu, Jiang, Huazhong, Shi
openaire +2 more sources
mRNA Stability Assay Using Transcription Inhibition by Actinomycin D in Mouse Pluripotent Stem Cells
Bio-Protocol, 2018 Gene expression is regulated through multiple steps at both transcriptional and post-transcriptional levels. The net abundance of mature mRNA species in cells is determined by the balance between transcription and degradation.
Madara Ratnadiwakara, Minna-Liisa Änkö
doaj +1 more source
The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
Non-Coding RNA, 2021 mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay.
Maialen Sebastian-delaCruz +4 more
doaj +1 more source
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
Nature Communications, 2022 The authors develop an RNA sequencing-based platform, PERSIST-seq, to simultaneously delineate in-cell mRNA stability, ribosome load, and in-solution stability of a diverse mRNA library to derive design principles for improved mRNA therapeutics.
Kathrin Leppek +28 more
doaj +1 more source
PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs [PDF]
, 2018 A large number of RNA binding proteins (RBPs) and miRNAs bind to the 3′ untranslated regions of mRNA, but methods to dissect their function and interactions are lacking.
Chaudhari, Hemangi G +3 more
core +3 more sources
Matrin 3 Binds and Stabilizes mRNA
PLoS ONE, 2011 Matrin 3 (MATR3) is a highly conserved, inner nuclear matrix protein with two zinc finger domains and two RNA recognition motifs (RRM), whose function is largely unknown. Recently we found MATR3 to be phosphorylated by the protein kinase ATM, which activates the cellular response to double strand breaks in the DNA. Here, we show that MATR3 interacts in
Salton, M. +6 more
openaire +5 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source