Results 31 to 40 of about 3,135,932 (255)
Translation Initiation Control of RNase E-Mediated Decay of Polycistronic gal mRNA
Frontiers in Molecular Biosciences, 2020 In bacteria, mRNA decay is a major mechanism for regulating gene expression. In Escherichia coli, mRNA decay initiates with endonucleolytic cleavage by RNase E. Translating ribosomes impede RNase E cleavage, thus providing stability to mRNA.
Heung Jin Jeon +6 more
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Long Non-coding RNAs in the Cytoplasm
Genomics, Proteomics & Bioinformatics, 2016 An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs.
Farooq Rashid, Abdullah Shah, Ge Shan
doaj +1 more source
Role of mRNA stability during bacterial adaptation. [PDF]
PLoS ONE, 2013 Bacterial adaptation involves extensive cellular reorganization. In particular, growth rate adjustments are associated with substantial modifications of gene expression and mRNA abundance.
Clémentine Dressaire +6 more
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The CAF1-NOT complex of trypanosomes
Frontiers in Genetics, 2014 In African trypanosomes, there is no control of transcription initiation by RNA polymerase II at the level of individual protein-coding genes. Transcription is polycistronic, and individual mRNAs are excised by trans splicing and polyadenylation.
Esteban eErben +2 more
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Genetic variants associated mRNA stability in lung
BMC Genomics, 2022 Background Expression quantitative trait loci (eQTLs) analyses have been widely used to identify genetic variants associated with gene expression levels to understand what molecular mechanisms underlie genetic traits. The resultant eQTLs might affect the
Jian-Rong Li +4 more
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Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8 [PDF]
, 2009 The U5 snRNA loop 1 aligns the 5' and 3' exons for ligation during the second step of pre-mRNA splicing. U5 is intimately associated with Prp8, which mediates pre-mRNA repositioning within the catalytic core of the spliceosome and interacts directly with
David Barrass, J. +5 more
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RNA Stability Measurements Using RT-qPCR in Arabidopsis Seedlings
Bio-Protocol, 2020 Steady-state mRNA levels are determined by both the rates of transcription and degradation. Regulation of mRNA stability and/or degradation are key factors that can significantly affect mRNA levels and its biological functions.
Tianran Jia, Brandon Le
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Cytoplasmic 5’-3’ exonuclease Xrn1p is also a genome-wide transcription factor in yeast
Frontiers in Genetics, 2014 The 5’ to 3’ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects ...
Daniel A Medina +5 more
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Pharmaceutics, 2022 Lipid nanoparticles (LNPs) are currently in the spotlight as delivery systems for mRNA therapeutics and have been used in the Pfizer/BioNTech and Moderna COVID-19 vaccines.
Mariko Kamiya +8 more
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Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system [PDF]
, 2015 This work was supported by Medical Research Scotland (FRG353 to VAS), the FP7- Directorate-General for Research and Innovation of the European Commission (EU HEALTHF4-2012-305033 to Coordinating Action Systems Medicine to DJH); the Chief Scientist Office
Smith, V. Anne +7 more
core +1 more source