Results 31 to 40 of about 609,843 (298)
Cytoplasmic 5’-3’ exonuclease Xrn1p is also a genome-wide transcription factor in yeast
Frontiers in Genetics, 2014 The 5’ to 3’ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects ...
Daniel A Medina +5 more
doaj +1 more source
Stochastic Modeling of Expression Kinetics Identifies Messenger Half-Lives and Reveals Sequential Waves of Co-ordinated Transcription and Decay [PDF]
, 2012 The transcriptome in a cell is finely regulated by a large number of molecular mechanisms able to control the balance between mRNA production and degradation. Recent experimental findings have evidenced that fine and specific regulation of degradation is
Cacace, Filippo +4 more
core +3 more sources
Pharmaceutics, 2022 Lipid nanoparticles (LNPs) are currently in the spotlight as delivery systems for mRNA therapeutics and have been used in the Pfizer/BioNTech and Moderna COVID-19 vaccines.
Mariko Kamiya +8 more
doaj +1 more source
Down-regulatory mechanism of mammea E/BB from Mammea siamensis seed extract on Wilms' Tumor 1 expression in K562 cells. [PDF]
, 2016 BackgroundWilms' tumor 1 (WT1) is a biological marker for predicting leukemia progression. In this study, mammea E/BB, an active compound from Saraphi (Mammea siamensis) seed extract was examined for its effect on down-regulatory mechanism of WT1 gene ...
Ampasavate, Chadarat +6 more
core +1 more source
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source
Viruses, 2013 Nuclear mRNA export is a highly complex and regulated process in cells. Cellular transcripts must undergo successful maturation processes, including splicing, 5'-, and 3'-end processing, which are essential for assembly of an export competent ...
Adrian Whitehouse +3 more
doaj +1 more source
Mitochondrial Molecular Adaptations and Life History Strategies Coevolve in Plants [PDF]
, 2008 Messenger RNA secondary structure prevents mutations at functionally important sites. Mutations at exposed sites would cause micro-adaptations, niche-specialization, and therefore, can be thought to promote K-strategists. Exposing, rather than protecting,
Basuthkar J. Rao, Neeraja M. Krishnan
core +2 more sources
Discover Oncology, 2023 As a frontline treatment for patients with advanced hepatocellular carcinoma (HCC), sorafenib is an effective drug approved by the Food and Drug Administration (FDA).
Fei Chen, Liang Wang
doaj +1 more source
Concatemeric Broccoli reduces mRNA stability and induces aggregates
PLoS ONE, 2021 Fluorogenic aptamers are an alternative to established methodology for real-time imaging of RNA transport and dynamics. We developed Broccoli-aptamer concatemers ranging from 4 to 128 substrate-binding site repeats and characterized their behavior fused ...
Marco R. Rink +8 more
doaj +2 more sources
Frontiers in Bioengineering and Biotechnology, 2020 High gene expression of enzymes partaking in recombinant production pathways is a desirable trait among cell factories belonging to all different kingdoms of life.
Dário Neves +5 more
doaj +1 more source