Results 11 to 20 of about 4,875 (208)

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

OncoImmunology, 2019
Protective T cell responses against tumors require the production of Interferon gamma (IFN-γ). However, tumor-infiltrating T cells (TILs) gradually lose their capacity to produce IFN-γ and therefore fail to clear malignant cells.
Fiamma Salerno, Aurelie Guislain, Julian J. Freen-Van Heeren, Benoit P. Nicolet, Howard A. Young, Monika C. Wolkers   +5 more
doaj   +1 more source

The link between adjacent codon pairs and mRNA stability

BMC Genomics, 2017
Background Evidence in diverse organisms suggests that codon optimality is a major determinant of mRNA translation and degradation. Codon optimality is thought to act by modulating the efficiency of ribosome elongation.
Yuriko Harigaya, Roy Parker
doaj   +1 more source

The Kaposi’s sarcoma-associated herpesvirus ORF57 protein and its multiple roles in mRNA biogenesis

Frontiers in Microbiology, 2012
Post-transcriptional events which regulate mRNA biogenesis are fundamental to the control of gene expression. A nascent mRNA is therefore steered through multimeric RNA-protein complexes that mediate its capping, splicing, polyadenylation, nuclear export
Brian R Jackson, Marko eNoerenberg, Adrian eWhitehouse   +2 more
doaj   +1 more source

Translation Initiation Control of RNase E-Mediated Decay of Polycistronic gal mRNA

Frontiers in Molecular Biosciences, 2020
In bacteria, mRNA decay is a major mechanism for regulating gene expression. In Escherichia coli, mRNA decay initiates with endonucleolytic cleavage by RNase E. Translating ribosomes impede RNase E cleavage, thus providing stability to mRNA.
Heung Jin Jeon, Changjo Kang, Monford Paul Abishek N, Yonho Lee, Xun Wang, Dhruba K. Chattoraj, Heon M. Lim   +6 more
doaj   +1 more source

Role of mRNA stability during bacterial adaptation. [PDF]

PLoS ONE, 2013
Bacterial adaptation involves extensive cellular reorganization. In particular, growth rate adjustments are associated with substantial modifications of gene expression and mRNA abundance.
Clémentine Dressaire, Flora Picard, Emma Redon, Pascal Loubière, Isabelle Queinnec, Laurence Girbal, Muriel Cocaign-Bousquet   +6 more
doaj   +1 more source

Genetic variants associated mRNA stability in lung

BMC Genomics, 2022
Background Expression quantitative trait loci (eQTLs) analyses have been widely used to identify genetic variants associated with gene expression levels to understand what molecular mechanisms underlie genetic traits. The resultant eQTLs might affect the
Jian-Rong Li, Mabel Tang, Yafang Li, Christopher I. Amos, Chao Cheng   +4 more
doaj   +1 more source

The CAF1-NOT complex of trypanosomes

Frontiers in Genetics, 2014
In African trypanosomes, there is no control of transcription initiation by RNA polymerase II at the level of individual protein-coding genes. Transcription is polycistronic, and individual mRNAs are excised by trans splicing and polyadenylation.
Esteban eErben, Chaitali eChakraborty, Christine eClayton   +2 more
doaj   +1 more source

Long Non-coding RNAs in the Cytoplasm

Genomics, Proteomics & Bioinformatics, 2016
An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs.
Farooq Rashid, Abdullah Shah, Ge Shan
doaj   +1 more source

Stability Study of mRNA-Lipid Nanoparticles Exposed to Various Conditions Based on the Evaluation between Physicochemical Properties and Their Relation with Protein Expression Ability

Pharmaceutics, 2022
Lipid nanoparticles (LNPs) are currently in the spotlight as delivery systems for mRNA therapeutics and have been used in the Pfizer/BioNTech and Moderna COVID-19 vaccines.
Mariko Kamiya, Makoto Matsumoto, Kazuma Yamashita, Tatsunori Izumi, Maho Kawaguchi, Shusaku Mizukami, Masako Tsurumaru, Hidefumi Mukai, Shigeru Kawakami   +8 more
doaj   +1 more source

Cytoplasmic 5’-3’ exonuclease Xrn1p is also a genome-wide transcription factor in yeast

Frontiers in Genetics, 2014
The 5’ to 3’ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects ...
Daniel A Medina, Antonio eJordán-Pla, Gonzalo eMillán-Zambrano, Sebastián eChávez, Mordechai eChoder, José E Pérez-Ortín   +5 more
doaj   +1 more source