Results 11 to 20 of about 609,843 (298)
Translation and mRNA Stability Control
Annual Review of Biochemistry, 2023 Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the post-transcriptional process that profoundly impact protein production in a cell. While it is widely known that ribosomes produce proteins, studies during the past decade have surprisingly revealed that ribosomes also control mRNA stability in a codon-dependent ...
Qiushuang, Wu, Ariel A, Bazzini
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Biology Open, 2020 During Drosophila and vertebrate brain development, the conserved transcription factor Prospero/Prox1 is an important regulator of the transition between proliferation and differentiation.
Tamsin J. Samuels +9 more
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Fluorescence-based quantification of messenger RNA and plasmid DNA decay kinetics in extracellular biological fluids and cell extracts [PDF]
, 2020 Extracellular and intracellular degradation of nucleic acids remains an issue in non-viral gene therapy. Understanding biodegradation is critical for the rational design of gene therapeutics in order to maintain stability and functionality at the target ...
Braeckmans, Kevin +6 more
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Stability of mRNA/DNA and DNA/DNA duplexes affects mRNA transcription. [PDF]
PLoS ONE, 2007 Nucleic acids, due to their structural and chemical properties, can form double-stranded secondary structures that assist the transfer of genetic information and can modulate gene expression.
Rayna I Kraeva +5 more
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mRNA stability in the nucleus [PDF]
Journal of Zhejiang University SCIENCE B, 2014 Eukaryotic gene expression is controlled by different levels of biological events, such as transcription factors regulating the timing and strength of transcripts production, alteration of transcription rate by RNA processing, and mRNA stability during RNA processing and translation. RNAs, especially mRNAs, are relatively vulnerable molecules in living
Han, Liu, Min, Luo, Ji-kai, Wen
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PABPC1——mRNA stability, protein translation and tumorigenesis
Frontiers in Oncology, 2022 Mammalian poly A-binding proteins (PABPs) are highly conserved multifunctional RNA-binding proteins primarily involved in the regulation of mRNA translation and stability, of which PABPC1 is considered a central regulator of cytoplasmic mRNA homing and ...
Ya Qi, Min Wang, Qi Jiang
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Genome-wide profiling of uncapped mRNA [PDF]
, 2012 Gene transcripts are under extensive posttranscriptional regulation, including the regulation of their stability. A major route for mRNA degradation produces uncapped mRNAs, which can be generated by decapping enzymes, endonucleases, and small RNAs ...
BD Gregory +9 more
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Cellular polyamines modulate mRNA stability [PDF]
Plant Signaling & Behavior, 2017 Polyamines (PAs) are polycationic compounds found in all living organisms and play crucial roles in growth and survival. PAs interact with and modulate the functions of anionic macromolecules such as DNA, RNA and proteins. LHR1/PUT3 is a polyamine influx transporter localized in the plasma membrane in Arabidopsis.
Haoxi Chai, Wannian Yang, Huazhong Shi
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Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells
OncoImmunology, 2019 Protective T cell responses against tumors require the production of Interferon gamma (IFN-γ). However, tumor-infiltrating T cells (TILs) gradually lose their capacity to produce IFN-γ and therefore fail to clear malignant cells.
Fiamma Salerno +5 more
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The link between adjacent codon pairs and mRNA stability
BMC Genomics, 2017 Background Evidence in diverse organisms suggests that codon optimality is a major determinant of mRNA translation and degradation. Codon optimality is thought to act by modulating the efficiency of ribosome elongation.
Yuriko Harigaya, Roy Parker
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