Results 1 to 10 of about 87,391 (262)
Nature Communications, 2022 Nucleocytoplasmic shuttling of several yeast mRNA decay factors regulates transcription and initiates a novel mRNA decay pathway; shuttling is controlled by the decaying RNA and is critical for coping with environmental changes.
Shiladitya Chattopadhyay +15 more
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Regulation of cytoplasmic mRNA decay [PDF]
Nature Reviews Genetics, 2012 Discoveries made over the past 20 years highlight the importance of mRNA decay as a means of modulating gene expression and thereby protein production. Up until recently, studies largely focused on identifying cis-acting sequences that serve as mRNA stability or instability elements, the proteins that bind these elements, how the process of translation
Daniel R Schoenberg +2 more
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Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity
Cell Reports, 2019 Summary: Proper transcriptome reprogramming is critical for hosts to launch an effective defense response upon pathogen attack. How immune-related genes are regulated at the posttranscriptional level remains elusive.
Xiao Yu +8 more
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Cell ReportsSummary: Developing an effective mRNA therapeutic often requires maximizing protein output per delivered mRNA molecule. We previously found that coding sequence (CDS) design can substantially affect protein output, with mRNA variants containing more ...
Alicia A. Bicknell +15 more
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Regulation of gene expression in trypanosomatids: living with polycistronic transcription [PDF]
Open Biology, 2019 In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are excised by trans-splicing and polyadenylation. The lack of individual gene transcription control is compensated by control of mRNA processing, translation and ...
Christine Clayton
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ZFP36-mediated mRNA decay regulates metabolism
Cell Reports, 2023 Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have ...
Andrew C. Cicchetto +11 more
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The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels. [PDF]
PLoS Genetics, 2012 Recent gene expression QTL (eQTL) mapping studies have provided considerable insight into the genetic basis for inter-individual regulatory variation. However, a limitation of all eQTL studies to date, which have used measurements of steady-state gene ...
Athma A Pai +11 more
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Complex degradation processes lead to non-exponential decay patterns and age-dependent decay rates of messenger RNA. [PDF]
PLoS ONE, 2013 Experimental studies on mRNA stability have established several, qualitatively distinct decay patterns for the amount of mRNA within the living cell.
Carlus Deneke +2 more
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mBio, 2022 The Bacillus subtilis genome encodes four 3′ exoribonucleases: polynucleotide phosphorylase (PNPase), RNase R, RNase PH, and YhaM. Previous work showed that PNPase, encoded by the pnpA gene, is the major 3′ exonuclease involved in mRNA turnover; in a ...
Shivani Chhabra +4 more
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CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner
RNA Biology, 2022 Circadian clocks are an endogenous internal timekeeping mechanism that drives the rhythmic expression of genes, controlling the 24 h oscillatory pattern in behaviour and physiology.
Haytham Mohamed Aly Mohamed +6 more
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