Nature Communications, 2022 Nucleocytoplasmic shuttling of several yeast mRNA decay factors regulates transcription and initiates a novel mRNA decay pathway; shuttling is controlled by the decaying RNA and is critical for coping with environmental changes.
Shiladitya Chattopadhyay +15 more
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Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease [PDF]
Nature Communications, 2017 “mRNA abundance is determined by the rates of transcription and decay. Here, the authors propose a method for estimating the rate of differential mRNA decay from RNA-seq data and model mRNA stability in the brain, suggesting a link between mRNA stability
Rached Alkallas +3 more
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The decapping activator Edc3 and the Q/N-rich domain of Lsm4 function together to enhance mRNA stability and alter mRNA decay pathway dependence in Saccharomyces cerevisiae [PDF]
Biology Open, 2016 The rate and regulation of mRNA decay are major elements in the proper control of gene expression. Edc3 and Lsm4 are two decapping activator proteins that have previously been shown to function in the assembly of RNA granules termed P bodies.
Susanne Huch +5 more
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ZFP36-mediated mRNA decay regulates metabolism
Cell Reports, 2023 Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have ...
Andrew C. Cicchetto +11 more
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Uridylation regulates mRNA decay directionality in fission yeast [PDF]
Nature CommunicationsCytoplasmic mRNA decay is effected by exonucleolytic degradation in either the 5’ to 3’ or 3’ to 5’ direction. Pervasive terminal uridylation is implicated in mRNA degradation, however, its functional relevance for bulk mRNA turnover remains poorly ...
Maciej Grochowski +9 more
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Nonsense mRNA suppression via nonstop decay
eLife, 2018 Nonsense-mediated mRNA decay is the process by which mRNAs bearing premature stop codons are recognized and cleared from the cell. While considerable information has accumulated regarding recognition of the premature stop codon, less is known about the ...
Joshua A Arribere, Andrew Z Fire
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Regulation of gene expression in trypanosomatids: living with polycistronic transcription [PDF]
Open Biology, 2019 In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are excised by trans-splicing and polyadenylation. The lack of individual gene transcription control is compensated by control of mRNA processing, translation and ...
Christine Clayton
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The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels. [PDF]
PLoS Genetics, 2012 Recent gene expression QTL (eQTL) mapping studies have provided considerable insight into the genetic basis for inter-individual regulatory variation. However, a limitation of all eQTL studies to date, which have used measurements of steady-state gene ...
Athma A Pai +11 more
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Complex degradation processes lead to non-exponential decay patterns and age-dependent decay rates of messenger RNA. [PDF]
PLoS ONE, 2013 Experimental studies on mRNA stability have established several, qualitatively distinct decay patterns for the amount of mRNA within the living cell.
Carlus Deneke +2 more
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mBio, 2022 The Bacillus subtilis genome encodes four 3′ exoribonucleases: polynucleotide phosphorylase (PNPase), RNase R, RNase PH, and YhaM. Previous work showed that PNPase, encoded by the pnpA gene, is the major 3′ exonuclease involved in mRNA turnover; in a ...
Shivani Chhabra +4 more
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