Results 1 to 10 of about 998,624 (255)

Nonsense mRNA suppression via nonstop decay [PDF]

eLife, 2018
Nonsense-mediated mRNA decay is the process by which mRNAs bearing premature stop codons are recognized and cleared from the cell. While considerable information has accumulated regarding recognition of the premature stop codon, less is known about the ...
Joshua A Arribere, Andrew Z Fire
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Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition

eLife, 2022
Accurate control of the cell cycle is critical for development and tissue homeostasis, and requires precisely timed expression of many genes. Cell cycle gene expression is regulated through transcriptional and translational control, as well as through ...
Lenno Krenning, Stijn Sonneveld, Marvin E Tanenbaum   +2 more
doaj   +1 more source

Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation

Journal of Lipid Research, 1995
To better understand the accelerated decay of fatty acid synthase (FAS) message that occurs after glucose deprivation (J. Biol. Chem. 1993. 268: 6961-6970), we characterized the 3‘ terminus of the human message and the kinetics of FAS mRNA decay in HepG2
C F Semenkovich, T Coleman, F T Fiedorek, Jr   +2 more
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Cotranslational microRNA mediated messenger RNA destabilization

eLife, 2016
MicroRNAs are small (22 nucleotide) regulatory molecules that play important roles in a wide variety of biological processes. These RNAs, which bind to targeted mRNAs via limited base pairing interactions, act to reduce protein production from those ...
Trinh To Tat, Patricia A Maroney, Sangpen Chamnongpol, Jeff Coller, Timothy W Nilsen   +4 more
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The CAF1-NOT complex of trypanosomes

Frontiers in Genetics, 2014
In African trypanosomes, there is no control of transcription initiation by RNA polymerase II at the level of individual protein-coding genes. Transcription is polycistronic, and individual mRNAs are excised by trans splicing and polyadenylation.
Esteban eErben, Chaitali eChakraborty, Christine eClayton   +2 more
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Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3′ Uridylated Intermediates Degraded by DIS3L2

Cell Reports, 2015
Apoptosis is a tightly coordinated cell death program that damages mitochondria, DNA, proteins, and membrane lipids. Little is known about the fate of RNA as cells die.
Marshall P. Thomas, Xing Liu, Jennifer Whangbo, Geoffrey McCrossan, Keri B. Sanborn, Emre Basar, Michael Walch, Judy Lieberman   +7 more
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Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease

Nature Communications, 2017
“mRNA abundance is determined by the rates of transcription and decay. Here, the authors propose a method for estimating the rate of differential mRNA decay from RNA-seq data and model mRNA stability in the brain, suggesting a link between mRNA stability
Rached Alkallas, Lisa Fish, Hani Goodarzi, Hamed S. Najafabadi   +3 more
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The decapping activator Edc3 and the Q/N-rich domain of Lsm4 function together to enhance mRNA stability and alter mRNA decay pathway dependence in Saccharomyces cerevisiae

Biology Open, 2016
The rate and regulation of mRNA decay are major elements in the proper control of gene expression. Edc3 and Lsm4 are two decapping activator proteins that have previously been shown to function in the assembly of RNA granules termed P bodies.
Susanne Huch, Maren Müller, Mridula Muppavarapu, Jessie Gommlich, Vidya Balagopal, Tracy Nissan   +5 more
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Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells. [PDF]

PLoS ONE, 2010
Dramatic changes in gene expression occur in response to extracellular stimuli and during differentiation. Although transcriptional effects are important, alterations in mRNA decay also play a major role in achieving rapid and massive changes in mRNA ...
Jerome E Lee, Ju Youn Lee, Jeffrey Wilusz, Bin Tian, Carol J Wilusz   +4 more
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Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries

Viruses, 2016
The human immunodeficiency virus type-1 (HIV-1) unspliced transcript is used both as mRNA for the synthesis of structural proteins and as the packaged genome. Given the presence of retained introns and instability AU-rich sequences, this viral transcript
Daniela Toro-Ascuy, Bárbara Rojas-Araya, Fernando Valiente-Echeverría, Ricardo Soto-Rifo   +3 more
doaj   +1 more source