Results 21 to 30 of about 998,624 (255)
eLife, 2021 The PI3K-related kinase (PIKK) SMG1 monitors the progression of metazoan nonsense-mediated mRNA decay (NMD) by phosphorylating the RNA helicase UPF1. Previous work has shown that the activity of SMG1 is impaired by small molecule inhibitors, is reduced ...
Lukas M Langer +3 more
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Cells, 2020 Translation is spatiotemporally regulated and endoplasmic reticulum (ER)-associated mRNAs are generally in efficient translation. It is unclear whether the ER-associated mRNAs are deadenylated or degraded on the ER surface in situ or in the cytosol. Here,
Tian-Li Duan +3 more
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Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay [PDF]
, 2012 5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes (LT), a group of inflammatory lipid mediators derived from arachidonic acid.
Laura Pufahl (182448) +26 more
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PELOTA and HBS1 suppress co‐translational messenger RNA decay in Arabidopsis
Plant Direct, 2023 Various messenger RNA (mRNA) decay mechanisms play major roles in controlling mRNA quality and quantity in eukaryotic organisms under different conditions.
Rong Guo, Brian D. Gregory
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Quantification of pre-mRNA escape rate and synergy in splicing [PDF]
, 2014 Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape the nucleus with a retained intron. Intron retention can control gene expression and increase proteome diversity.
Becskei, Attila +13 more
core +1 more source
Immunity of the Saccharomyces cerevisiae SSY5 mRNA to nonsense-mediated mRNA decay.
Frontiers in Molecular Biosciences, 2014 The nonsense-mediated mRNA decay (NMD) pathway is a specialized pathway that triggers the rapid degradation of select mRNAs. Initially identified as a pathway that degrades mRNAs with premature termination codons, NMD is now recognized as a pathway that ...
Bessie Wanja Kebaara +3 more
doaj +1 more source
On the role of ras and BRF1 in the regulation of ARE-dependent mRNA-turnover [PDF]
, 2004 Stability of the mRNAs of cytokines, chemokines, growth-factors, protooncogenes and others are regulated via an AU-rich element (ARE) in their 3’ untranslated region (UTR).
Leuenberger, Sabrina Angélique
core +1 more source
eLife, 2018 The cytoplasmic abundance of mRNAs is strictly controlled through a balance of production and degradation. Whereas the control of mRNA synthesis through transcription has been well characterized, less is known about the regulation of mRNA turnover, and a
Leon Y Chan +4 more
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AU-rich element-mediated mRNA decay can occur independently of the miRNA machinery in mouse embryonic fibroblasts and Drosophila S2-cells. [PDF]
, 2012 AU-rich elements (AREs) are regulatory sequences located in the 3' untranslated region of many short-lived mRNAs. AREs are recognized by ARE-binding proteins and cause rapid mRNA degradation.
Stoecklin, Georg +7 more
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Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis
eLife, 2021 RNA abundance is generally sensitive to perturbations in decay and synthesis rates, but crosstalk between RNA polymerase II transcription and cytoplasmic mRNA degradation often leads to compensatory changes in gene expression.
Christopher Duncan-Lewis +3 more
doaj +1 more source