Results 21 to 30 of about 87,391 (262)
mRNA–mRNA duplexes that autoelicit Staufen1-mediated mRNA decay [PDF]
Nature Structural & Molecular Biology, 2013 We report a new mechanism by which human mRNAs cross-talk: an Alu element in the 3' untranslated region (3' UTR) of one mRNA can base-pair with a partially complementary Alu element in the 3' UTR of a different mRNA, thereby creating a Staufen1 (STAU1)-binding site (SBS). STAU1 binding to a 3'-UTR SBS was previously shown to trigger STAU1-mediated mRNA
Gong, Chenguang +2 more
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Viral Manipulation of Host Mrna Decay [PDF]
Future Virology, 2018 Viruses alter host-cell gene expression at many biochemical levels, such as transcription, translation, mRNA splicing and mRNA decay in order to create a cellular environment suitable for viral replication. In this review, we discuss mechanisms by which viruses manipulate host-gene expression at the level of mRNA decay in order to enable the virus to ...
Liang, Guo +2 more
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Cell Reports, 2015 Eukaryotic mRNA degradation often initiates with the recruitment of the CCR4-NOT deadenylase complex and decay factors to the mRNA 3′ terminus. How the 3′-proximal decay machinery interacts with the 5′-terminal cap structure in order to engender mRNA ...
Tamiko Nishimura +6 more
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Cellular variability of nonsense-mediated mRNA decay
Nature Communications, 2021 Here the author developed a single-cell reporter system to identify cell-to-cell variability of nonsense-mediated mRNA decay (NMD). This approach provides a sensitive tool to investigate cellular heterogeneity of NMD in various physiological conditions.
Hanae Sato, Robert H. Singer
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F1000Research, 2018 Gene expression is typically quantified as RNA abundance, which is influenced by both synthesis (transcription) and decay. Cytoplasmic decay typically initiates by deadenylation, after which decay can occur through any of three cytoplasmic decay pathways.
Leslie E Sieburth, Jessica N Vincent
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Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex
Frontiers in Immunology, 2021 Development of lymphocytes is precisely regulated by various mechanisms. In addition to transcriptional rates, post-transcriptional regulation of mRNA abundance contributes to differentiation of lymphocytes. mRNA decay is a post-transcriptional mechanism
Taishin Akiyama +2 more
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Is there a classical nonsense-mediated decay pathway in trypanosomes? [PDF]
PLoS ONE, 2011 In many eukaryotes, messenger RNAs with premature termination codons are destroyed by a process called "nonsense-mediated decay", which requires the RNA helicase Upf1 and also, usually, an interacting factor, Upf2.
Praveen Delhi +4 more
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eLife, 2022 Accurate control of the cell cycle is critical for development and tissue homeostasis, and requires precisely timed expression of many genes. Cell cycle gene expression is regulated through transcriptional and translational control, as well as through ...
Lenno Krenning +2 more
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Journal of Lipid Research, 1995 To better understand the accelerated decay of fatty acid synthase (FAS) message that occurs after glucose deprivation (J. Biol. Chem. 1993. 268: 6961-6970), we characterized the 3‘ terminus of the human message and the kinetics of FAS mRNA decay in HepG2
C F Semenkovich +2 more
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The role of AUF1 in regulated mRNA decay [PDF]
WIREs RNA, 2010 AbstractMessenger ribonucleic acid (mRNA) turnover is a major control point in gene expression. In mammals, many mRNAs encoding inflammatory cytokines, oncoproteins, and G‐protein‐coupled receptors are destabilized by the presence of AU‐rich elements (AREs) in their 3′‐untranslated regions.
Frances M, Gratacós, Gary, Brewer
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