Results 21 to 30 of about 156,480 (199)
Staufen‐mediated
WIREs RNA, 2013 Staufen1 (STAU1)‐mediated mRNA decay (SMD) is an mRNA degradation process in mammalian cells that is mediated by the binding of STAU1 to a STAU1‐binding site (SBS) within the 3′‐untranslated region (3′‐UTR) of target mRNAs. During SMD, STAU1, a double‐stranded (ds) RNA‐binding protein, recognizes dsRNA structures formed either by intramolecular base ...
Eonyoung, Park, Lynne E, Maquat
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Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. [PDF]
, 2015 Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population.
Blackshear, Perry J +7 more
core +2 more sources
eLife, 2018 The cytoplasmic abundance of mRNAs is strictly controlled through a balance of production and degradation. Whereas the control of mRNA synthesis through transcription has been well characterized, less is known about the regulation of mRNA turnover, and a
Leon Y Chan +4 more
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Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis
eLife, 2021 RNA abundance is generally sensitive to perturbations in decay and synthesis rates, but crosstalk between RNA polymerase II transcription and cytoplasmic mRNA degradation often leads to compensatory changes in gene expression.
Christopher Duncan-Lewis +3 more
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Stochastic Modeling of Expression Kinetics Identifies Messenger Half-Lives and Reveals Sequential Waves of Co-ordinated Transcription and Decay [PDF]
, 2012 The transcriptome in a cell is finely regulated by a large number of molecular mechanisms able to control the balance between mRNA production and degradation. Recent experimental findings have evidenced that fine and specific regulation of degradation is
Cacace, Filippo +4 more
core +3 more sources
Fluorescence-based quantification of messenger RNA and plasmid DNA decay kinetics in extracellular biological fluids and cell extracts [PDF]
, 2020 Extracellular and intracellular degradation of nucleic acids remains an issue in non-viral gene therapy. Understanding biodegradation is critical for the rational design of gene therapeutics in order to maintain stability and functionality at the target ...
Braeckmans, Kevin +6 more
core +1 more source
Codon optimality and mRNA decay [PDF]
Cell Research, 2016 Recent evidence indicates that codon optimality is a broad determinant of mRNA stability. A study by Radhakrishnan et al. in Cell raises the possibility that the conserved DEAD-box protein Dhh1 underlies the phenomenon.
Yuriko, Harigaya, Roy, Parker
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Cell Reports, 2015 Eukaryotic mRNA degradation often initiates with the recruitment of the CCR4-NOT deadenylase complex and decay factors to the mRNA 3′ terminus. How the 3′-proximal decay machinery interacts with the 5′-terminal cap structure in order to engender mRNA ...
Tamiko Nishimura +6 more
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Viral Manipulation of Host Mrna Decay [PDF]
Future Virology, 2018 Viruses alter host-cell gene expression at many biochemical levels, such as transcription, translation, mRNA splicing and mRNA decay in order to create a cellular environment suitable for viral replication. In this review, we discuss mechanisms by which viruses manipulate host-gene expression at the level of mRNA decay in order to enable the virus to ...
Liang, Guo +2 more
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Cellular variability of nonsense-mediated mRNA decay
Nature Communications, 2021 Here the author developed a single-cell reporter system to identify cell-to-cell variability of nonsense-mediated mRNA decay (NMD). This approach provides a sensitive tool to investigate cellular heterogeneity of NMD in various physiological conditions.
Hanae Sato, Robert H. Singer
doaj +1 more source