Results 31 to 40 of about 156,480 (199)

A self-organized model for cell-differentiation based on variations of molecular decay rates [PDF]

, 2012
Systemic properties of living cells are the result of molecular dynamics governed by so-called genetic regulatory networks (GRN). These networks capture all possible features of cells and are responsible for the immense levels of adaptation ...
A Bhattacharjya, A Bossi, A Ciechanover, A Hoffmann, A Visel, AC Gavin, AP Capaldi, AU Viretta, B de Chassey, B Schwanhäusser, CC Guet, CG Langton, D Bratsun, D Das, D Ropers, D Stokić, EL Greer, EM Ozbudak, G Yagil, GM Church, H de Jong, H Kitano, I Shmulevich, J Gertz, J Gsponer, J Paulsson, JE Lee, JH Park, L Glass, L Glass, L Hood, L Pirkkala, M Mitchell, M Ptashne, M Rewieński, MA Beer, Manfred Pöchacker, Manuel Schölling, MB Burg, MJ Amorim, N Kashtan, NM Luscombe, P Smolen, Peter Csermely, R Casey, R Hanel, R Jothi, R Métivier, R Métivier, RP Zinzen, Rudolf Hanel, S Pigolotti, S Semsey, SA Kauffman, SA Vokes, Stefan Thurner, TE Turner, TI Lee, TR Burkard, X Qian, Z Tothova   +60 more
core   +4 more sources

Beyond transcription factors: roles of mRNA decay in regulating gene expression in plants [version 1; referees: 3 approved]

F1000Research, 2018
Gene expression is typically quantified as RNA abundance, which is influenced by both synthesis (transcription) and decay. Cytoplasmic decay typically initiates by deadenylation, after which decay can occur through any of three cytoplasmic decay pathways.
Leslie E Sieburth, Jessica N Vincent
doaj   +1 more source

Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex

Frontiers in Immunology, 2021
Development of lymphocytes is precisely regulated by various mechanisms. In addition to transcriptional rates, post-transcriptional regulation of mRNA abundance contributes to differentiation of lymphocytes. mRNA decay is a post-transcriptional mechanism
Taishin Akiyama, Taishin Akiyama, Tadashi Yamamoto   +2 more
doaj   +1 more source

Direct measurement of transcription rates reveals multiple mechanisms for configuration of the Arabidopsis ambient temperature response [PDF]

, 2014
Background Sensing and responding to ambient temperature is important for controlling growth and development of many organisms, in part by regulating mRNA levels.
Costa, Maria J. (Maria João), Finkenstädt, Bärbel, Penfield, Steven, Rand, D. A. (David A.), Sidaway-Lee, Kate   +4 more
core   +1 more source

Cytoplasmic RNA decay pathways - enzymes and mechanisms [PDF]

, 2016
RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work conducted over the last decades has defined the major mRNA decay pathways, as well as enzymes and their cofactors responsible for these processes. In contrast, our
Dziembowski, Andrzej, Tomecki, Rafał, Łabno, Anna   +2 more
core   +1 more source

Is there a classical nonsense-mediated decay pathway in trypanosomes? [PDF]

PLoS ONE, 2011
In many eukaryotes, messenger RNAs with premature termination codons are destroyed by a process called "nonsense-mediated decay", which requires the RNA helicase Upf1 and also, usually, an interacting factor, Upf2.
Praveen Delhi, Rafael Queiroz, Diana Inchaustegui, Mark Carrington, Christine Clayton   +4 more
doaj   +1 more source

Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition

eLife, 2022
Accurate control of the cell cycle is critical for development and tissue homeostasis, and requires precisely timed expression of many genes. Cell cycle gene expression is regulated through transcriptional and translational control, as well as through ...
Lenno Krenning, Stijn Sonneveld, Marvin E Tanenbaum   +2 more
doaj   +1 more source

The transcriptional inhibitor thiolutin blocks mRNA degradation. [PDF]

, 2008
Thiolutin is commonly used as a general inhibitor of transcription in yeast. It has been used to calculate mRNA decay rates by stopping the transcription and then determining the relative abundance of individual mRNAs at different times after inhibition.
Pelechano García, Vicente José, Pérez Ortín, José Enrique   +1 more
core   +2 more sources

Attenuated Codon Optimality Contributes to Neural-Specific mRNA Decay in Drosophila. [PDF]

, 2018
Tissue-specific mRNA stability is important for cell fate and physiology, but the mechanisms involved are not fully understood. We found that zygotic mRNA stability in Drosophila correlates with codon content: optimal codons are enriched in stable ...
Alhusaini, Najwa, Burow, Dana A, Cleary, Michael D, Coller, Jeff, Martin, Sophie, Quail, Jade F   +5 more
core   +2 more sources

Viruses and the cellular RNA decay machinery. [PDF]

, 2010
The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core   +1 more source