Results 11 to 20 of about 87,391 (262)
Initiation of mRNA decay in bacteria [PDF]
Cellular and Molecular Life Sciences, 2013 The instability of messenger RNA is fundamental to the control of gene expression. In bacteria, mRNA degradation generally follows an "all-or-none" pattern. This implies that if control is to be efficient, it must occur at the initiating (and presumably rate-limiting) step of the degradation process. Studies of E. coli and B.
S., Laalami, L., Zig, H., Putzer
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eLife, 2021 The PI3K-related kinase (PIKK) SMG1 monitors the progression of metazoan nonsense-mediated mRNA decay (NMD) by phosphorylating the RNA helicase UPF1. Previous work has shown that the activity of SMG1 is impaired by small molecule inhibitors, is reduced ...
Lukas M Langer +3 more
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Cells, 2020 Translation is spatiotemporally regulated and endoplasmic reticulum (ER)-associated mRNAs are generally in efficient translation. It is unclear whether the ER-associated mRNAs are deadenylated or degraded on the ER surface in situ or in the cytosol. Here,
Tian-Li Duan +3 more
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PELOTA and HBS1 suppress co‐translational messenger RNA decay in Arabidopsis
Plant Direct, 2023 Various messenger RNA (mRNA) decay mechanisms play major roles in controlling mRNA quality and quantity in eukaryotic organisms under different conditions.
Rong Guo, Brian D. Gregory
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A career in (mRNA) decay [PDF]
RNA, 2015 My entry into the RNA world began in 1967 when a visiting lecturer at the University of Toronto, the late Dr. Gordon Tener, inspired my interest in RNA. Various aspects of RNA biology, from ribosomes to plant viruses, occupied my attention during the early stages of my career.
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Coupling mRNA Synthesis and Decay [PDF]
Molecular and Cellular Biology, 2014 What has been will be again, what has been done will be done again; there is nothing new under the sun. -Ecclesiastes 1:9 (New International Version) Posttranscriptional regulation of gene expression has an important role in defining the phenotypic characteristics of an organism.
Katherine A, Braun, Elton T, Young
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Immunity of the Saccharomyces cerevisiae SSY5 mRNA to nonsense-mediated mRNA decay.
Frontiers in Molecular Biosciences, 2014 The nonsense-mediated mRNA decay (NMD) pathway is a specialized pathway that triggers the rapid degradation of select mRNAs. Initially identified as a pathway that degrades mRNAs with premature termination codons, NMD is now recognized as a pathway that ...
Bessie Wanja Kebaara +3 more
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Codon optimality and mRNA decay [PDF]
Cell Research, 2016 Recent evidence indicates that codon optimality is a broad determinant of mRNA stability. A study by Radhakrishnan et al. in Cell raises the possibility that the conserved DEAD-box protein Dhh1 underlies the phenomenon.
Yuriko, Harigaya, Roy, Parker
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eLife, 2018 The cytoplasmic abundance of mRNAs is strictly controlled through a balance of production and degradation. Whereas the control of mRNA synthesis through transcription has been well characterized, less is known about the regulation of mRNA turnover, and a
Leon Y Chan +4 more
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Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis
eLife, 2021 RNA abundance is generally sensitive to perturbations in decay and synthesis rates, but crosstalk between RNA polymerase II transcription and cytoplasmic mRNA degradation often leads to compensatory changes in gene expression.
Christopher Duncan-Lewis +3 more
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