Unveiling RNA structure-mediated regulations of RNA stability in wheat [PDF]
Nature CommunicationsDespite the critical role of mRNA stability in post-transcriptional gene regulation, research on this topic in wheat, a vital agricultural crop, remains unclear. Our study investigated the mRNA decay landscape of durum wheat (Triticum turgidum L.
Haidan Wu +10 more
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VfoldCPX Server: Predicting RNA-RNA Complex Structure and Stability. [PDF]
PLoS ONE, 2016 RNA-RNA interactions are essential for genomic RNA dimerization, mRNA splicing, and many RNA-related gene expression and regulation processes. The prediction of the structure and folding stability of RNA-RNA complexes is a problem of significant ...
Xiaojun Xu, Shi-Jie Chen
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N6-methyladenosine RNA modification promotes viral genomic RNA stability and infection [PDF]
Nature Communications, 2022 Wheat production is threatened by wheat yellow mosaic virus (WYMV). Here, via genome-wide association study, the authors report that a putative methyltransferase B positively regulates WYMV infection through enhancing viral genomic RNA stability by N6 ...
Tianye Zhang +16 more
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RNA Stability: A Review of the Role of Structural Features and Environmental Conditions [PDF]
MoleculesThe stability of RNA is a critical factor in determining its functionality and degradation in the cell. In recent years, it has been shown that the stability of RNA depends on a complex interaction of external and internal factors.
Igor V. Kornienko +4 more
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Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes [PDF]
Molecular MetabolismObjectives: Methylglyoxal (MG), a reactive aldehyde generated as a byproduct of glucose and lipid metabolism, is known to modify nucleic acids and proteins, altering their structure and function.
Edwin De Jesus Lopez Gonzalez +10 more
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RNA stability is regulated by both RNA polyadenylation and ATP levels, linking RNA and energy metabolisms in Escherichia coli [PDF]
mBioThe post-transcriptional process of RNA polyadenylation sits at the crossroads of energy metabolism and RNA metabolism. RNA polyadenylation is catalyzed by poly(A) polymerases, which use ATP as a substrate to add adenine to the 3′ end of RNAs, which can ...
Charlotte Roux +9 more
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RNA stability: a novel perspective on gene regulatory networks in bovine mastitis [PDF]
BMC GenomicsMastitis is a common and multifactorial disease in dairy cattle that leads to a major challenge in the livestock industry, in terms of both animal welfare and economic factors.
Mohammad Amin Shirazi +2 more
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Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability [PDF]
eLifeUntranslated regions (UTRs) contain crucial regulatory elements for RNA stability, translation and localization, so their integrity is indispensable for gene expression. Approximately 3.7% of genetic variants associated with diseases occur in UTRs, yet a
Jia-Ying Su +7 more
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Post-mortem Interval and Its Relation with the RNA Degradation in the Dental Pulp in Submerged Teeth
Arab Journal of Forensic Sciences & Forensic Medicine, 2021 Post-mortem interval is the time between death and the discovery of the body or human remains. Teeth are the most resistant structures of the human body, able to withstand extreme conditions such as high temperature, humidity, and post-mortem degradation.
Bruna S. Borges +3 more
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Incoherent dual regulation by a SAM-II riboswitch controlling translation at a distance
RNA Biology, 2022 In Sinorhizobium meliloti, the methionine biosynthesis genes metA and metZ are preceded by S-adenosyl-L-methionine (SAM) riboswitches of the SAM-II class. Upon SAM binding, structural changes in the metZ riboswitch were predicted to cause transcriptional
Robina Scheuer +5 more
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