Results 41 to 50 of about 882,207 (290)

An evaluation of RNA-seq differential analysis methods.

PLoS ONE, 2022
RNA-seq is a high-throughput sequencing technology widely used for gene transcript discovery and quantification under different biological or biomedical conditions.
Dongmei Li, Martin S Zand, Timothy D Dye, Maciej L Goniewicz, Irfan Rahman, Zidian Xie   +5 more
doaj   +1 more source

RNA structure prediction: progress and perspective

, 2014
Many recent exciting discoveries have revealed the versatility of RNAs and their importance in a variety of cellular functions which are strongly coupled to RNA structures.
Shi, Ya-Zhou, Tan, Zhi-Jie, Wang, Feng-Hua, Wu, Yuan-Yan   +3 more
core   +1 more source

Integrated microfluidic tmRNA purification and real-time NASBA device for molecular diagnostics. [PDF]

, 2008
We demonstrate the first integrated microfluidic tmRNA purification and nucleic acid sequence-based amplification (NASBA) device incorporating real-time detection.
Antonio J. Ricco, Breadmore, Bryan Lincoln, Cady, Caroline Viguier, Chen, Chen, Chung, Claus R. Poulsen, Compton, Cremonesi, Dittrich, Easley, Fu-Chun Huang, Glynn, Glynn, Gulliksen, Gulliksen, Ivan K. Dimov, Jaykus, Jose L. Garcia-Cordero, Justin O'Grady, Keiler, Khandurina, Lee, Lee, Legendre, Leone, Lien, Linder, Liu, Lorcan Kent, Luke P. Lee, Majella Maher, Monis, Nagrath, O' Grady, Paul Daly, Richard O'Kennedy, Sia, Terry J. Smith, Toriello, Tyagi, Tyagi, Tyagi, Waters, Younan Xia, Zhang, Zhang   +48 more
core   +1 more source

Nuclear Noncoding RNAs and Genome Stability [PDF]

Molecular Cell, 2016
In modern molecular biology, RNA has emerged as a versatile macromolecule capable of mediating an astonishing number of biological functions beyond its role as a transient messenger of genetic information. The recent discovery and functional analyses of new classes of noncoding RNAs (ncRNAs) have revealed their widespread use in many pathways ...
Jasbeer S, Khanduja, Isabel A, Calvo, Richard I, Joh, Ian T, Hill, Mo, Motamedi   +4 more
openaire   +2 more sources

Abnormal RNA stability in amyotrophic lateral sclerosis

Nature Communications, 2018
RNA instability may be a contributing factor in amyotrophic lateral sclerosis (ALS). Here the authors carry out genome-wide assessment of RNA synthesis and stability in cells derived from patients with C9orf72 ALS, sporadic ALS and healthy controls.
E. M. Tank, C. Figueroa-Romero, L. M. Hinder, K. Bedi, H. C. Archbold, X. Li, K. Weskamp, N. Safren, X. Paez-Colasante, C. Pacut, S. Thumma, M. T. Paulsen, K. Guo, J. Hur, M. Ljungman, E. L. Feldman, S. J. Barmada   +16 more
doaj   +1 more source

RNA Stability Measurements Using RT-qPCR in Arabidopsis Seedlings

Bio-Protocol, 2020
Steady-state mRNA levels are determined by both the rates of transcription and degradation. Regulation of mRNA stability and/or degradation are key factors that can significantly affect mRNA levels and its biological functions.
Tianran Jia, Brandon Le
doaj   +1 more source

Thermodynamic Features of Structural Motifs Formed by β-L-RNA. [PDF]

PLoS ONE, 2016
This is the first report to provide comprehensive thermodynamic and structural data concerning duplex, hairpin, quadruplex and i-motif structures in β-L-RNA series.
Marta Szabat, Dorota Gudanis, Weronika Kotkowiak, Zofia Gdaniec, Ryszard Kierzek, Anna Pasternak   +5 more
doaj   +1 more source

Crowding Promotes the Switch from Hairpin to Pseudoknot Conformation in Human Telomerase RNA

, 2011
Formation of a pseudoknot in the conserved RNA core domain in the ribonucleoprotein human telomerase is required for function. In vitro experiments show that the pseudoknot (PK) is in equilibrium with an extended hairpin (HP) structure.
Antal M., Asakura S., Blasco M. A., Bloomfield V. A., Cao S., Cao S., Chen J. L., Cheung M. S., Comolli L. R., D. Thirumalai, Denesyuk N. A., Dhar A., Feng J., Gilley D., Hyeon C., Kilburn D., Kirkpatrick T. R., Leontis N. B., Lin J. C., McGuffee S. R., Montange R. K., Natalia A. Denesyuk, Pincus D. L., Shaw M. R., Theimer C. A., Theimer C. A., Thirumalai D., Walter H., Whitford P. C., Xia T., Zhou H.-X.   +30 more
core   +1 more source

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP [PDF]

, 2013
Through controlling the nuclear level of active positive transcription elongation factor b (P-TEFb), the 7SK small nuclear RNA (snRNA) functions as a key regulator of RNA polymerase II transcription.
Bayfield, Bhattacharya, Biewenga, Blazek, Chambers, Cheng, de Almeida, Diribarne, Egloff, Goodall, Gupta, Gupta, Jeronimo, Jobert, Kiss, Kiss, Kiss, L. Muniz, Markert, Michels, Muniz, Nguyen, O'Keeffe, Peterlin, Price, S. Egloff, Shimba, Shimba, Shumyatsky, Shumyatsky, Singh, Singh, Singh, T. Kiss, Takahasi, Van Herreweghe, Wada, Wassarman, Yamaguchi, Yang, Yik, Yik, Zhou, Zhou   +43 more
core   +3 more sources

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]

, 2009
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Shobbir Hussain, Sandra Blanco Benavente, Elisabete Nascimento, Ilaria Dragoni, Agata Kurowski, Astrid Gillich, Peter Humphreys, Michaela Frye, Agris, Agris, Albee, Andersen, Andrews, Arnold, Blower, Blower, Boisvert, Brzezicha, Bujnicki, Clarke, Dephoure, Eliscovich, Frye, Frye, Gautier, Goshima, Greasley, Grosjean, Gruss, King, Liau, Ma, Nachury, Obara, Oeffinger, Raemaekers, Ribbeck, Rogakou, Sakita-Suto, Sato, Schmit, Schug, Taylor, Trieselmann, Tsai, Tscherne, Waikel, Watt, Wiese, Wu   +49 more
core   +1 more source