Mechanisms of circular RNA degradation [PDF]
Communications Biology, 2022 In this Perspective, Longxin Ren and co-authors summarise the role of circular RNAs in disease and discuss recent insights into how circular RNAs are metabolised in the cell.
Longxin Ren +7 more
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A Genetic Circuit Design for Targeted Viral RNA Degradation [PDF]
Bioengineering, 2023 Advances in synthetic biology have led to the design of biological parts that can be assembled in different ways to perform specific functions. For example, genetic circuits can be designed to execute specific therapeutic functions, including gene ...
Adebayo J. Bello +4 more
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Genome‐wide study of mRNA degradation and transcript elongation in Escherichia coli [PDF]
Molecular Systems Biology, 2015 An essential part of gene expression is the coordination of RNA synthesis and degradation, which occurs in the same cellular compartment in bacteria.
Huiyi Chen +3 more
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RNA Degradation in Pluripotent Stem Cells: Mechanisms, Crosstalk, and Fate Regulation [PDF]
CellsPluripotent stem cells (PSCs) exhibit remarkable self-renewal capacity and differentiation potential, necessitating tight regulation of gene expression at both transcriptional and post-transcriptional levels.
Seunghwa Jeong +3 more
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CRISPR/CasRx Proof-of-Concept for RNA Degradation: A Future Tool against RNA Viruses? [PDF]
Pharmaceuticals, 2021 Influenza viruses provide a great threat for the human population, causing highly contagious respiratory infections that can lead to serious clinical complications.
Diana Perez-SanJose +5 more
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NUDT2 initiates viral RNA degradation by removal of 5′-phosphates [PDF]
Nature Communications, 2021 RNA of some viruses is protected from degradation by a 5′ triphosphate group. Here the authors identify nudix hydrolase 2 (NUDT2) as novel antiviral defense protein that dephosphorylates viral RNA and thereby enables its degradation.
Beatrice T. Laudenbach +14 more
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Transcriptome maps of general eukaryotic RNA degradation factors [PDF]
eLife, 2019 RNA degradation pathways enable RNA processing, the regulation of RNA levels, and the surveillance of aberrant or poorly functional RNAs in cells. Here we provide transcriptome-wide RNA-binding profiles of 30 general RNA degradation factors in the yeast ...
Salma Sohrabi-Jahromi +7 more
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Single-exonuclease nanocircuits reveal the RNA degradation dynamics of PNPase and demonstrate potential for RNA sequencing [PDF]
Nature Communications, 2023 Observing the natural process of RNA degradation in real-time is a significant challenge. Here, the authors develop and use single-exonuclease nanocircuits to reveal the single-base degradation behaviour of PNPase, and demonstrate proof-of-principle RNA ...
Zhiheng Yang +6 more
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A dedicated diribonuclease resolves a key bottleneck for the terminal step of RNA degradation [PDF]
eLife, 2019 Degradation of RNA polymers, an ubiquitous process in all cells, is catalyzed by specific subsets of endo- and exoribonucleases that together recycle RNA fragments into nucleotide monophosphate.
Soo-Kyoung Kim +8 more
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RNA Biology, 2023 Histone mRNA degradation is controlled by the unique 3’ stem-loop of histone mRNA and the stem-loop binding protein (SLBP). As part of this process, the 3’ stem-loop is trimmed by the histone-specific 3’ exonuclease (3’hExo) and uridylated by the ...
Morgan Shine +6 more
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