Results 1 to 10 of about 5,666,730 (325)

Mechanisms of circular RNA degradation [PDF]

Communications Biology, 2022
In this Perspective, Longxin Ren and co-authors summarise the role of circular RNAs in disease and discuss recent insights into how circular RNAs are metabolised in the cell.
Longxin Ren, Qingshan Jiang, Liyi Mo, Lijie Tan, Qifei Dong, Lijuan Meng, Nanyang Yang, Guoqing Li   +7 more
doaj   +5 more sources

Technologies for Targeted RNA Degradation and Induced RNA Decay [PDF]

Chemical Reviews
The vast majority of the human genome codes for RNA, but RNA-targeting therapeutics account for a small fraction of approved drugs. As such, there is great incentive to improve old and develop new approaches to RNA targeting.
Gonçalo J. L. Bernardes
exaly   +5 more sources

A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance [PDF]

Molecular Cell
SUMMARY The RNA exosome plays critical roles in eukaryotic RNA degradation, but how it specifically recognizes its targets remains unclear. The PAXT connection is a nuclear adaptor that recruits the exosome to polyadenylated RNAs, especially transcripts ...
Soles LV, Liu L, Zou X, Yoon Y, Li S, Tian L, Valdez M, Yu AM, Yin H, Li W, Ding F, Seelig G, Li L, Shi Y.   +13 more
exaly   +3 more sources

RNA degradation is required for the germ-cell to maternal transition in Drosophila [PDF]

Current Biology, 2021
Summary In sexually reproducing animals, the oocyte contributes a large supply of RNAs that are essential to launch development upon fertilization. The mechanisms that regulate the composition of the maternal RNA contribution during oogenesis are unclear.
Prashanth Rangan, Justin Camacho, Miler T. Lee   +2 more
exaly   +3 more sources

Control of RNA degradation in cell fate decision. [PDF]

Front Cell Dev Biol, 2023
Cell fate is shaped by a unique gene expression program, which reflects the concerted action of multilayered precise regulation. Substantial research attention has been paid to the contribution of RNA biogenesis to cell fate decisions.
Deng M, Wang X, Xiong Z, Tang P.
europepmc   +2 more sources

Deep learning models for predicting RNA degradation via dual crowdsourcing. [PDF]

Nat Mach Intell, 2022
Medicines based on messenger RNA (mRNA) hold immense potential, as evidenced by their rapid deployment as COVID-19 vaccines. However, worldwide distribution of mRNA molecules has been limited by their thermostability, which is fundamentally limited by ...
Wayment-Steele HK, Kladwang W, Watkins AM, Kim DS, Tunguz B, Reade W, Demkin M, Romano J, Wellington-Oguri R, Nicol JJ, Gao J, Onodera K, Fujikawa K, Mao H, Vandewiele G, Tinti M, Steenwinckel B, Ito T, Noumi T, He S, Ishi K, Lee Y, Öztürk F, Chiu KY, Öztürk E, Amer K, Fares M, Eterna Participants, Das R.   +28 more
europepmc   +3 more sources

Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules. [PDF]

ACS Cent Sci, 2023
Nature has evolved intricate machinery to target and degrade RNA, and some of these molecular mechanisms can be adapted for therapeutic use. Small interfering RNAs and RNase H-inducing oligonucleotides have yielded therapeutic agents against diseases ...
Mikutis S, Rebelo M, Yankova E, Gu M, Tang C, Coelho AR, Yang M, Hazemi ME, Pires de Miranda M, Eleftheriou M, Robertson M, Vassiliou GS, Adams DJ, Simas JP, Corzana F, Schneekloth JS, Tzelepis K, Bernardes GJL.   +17 more
europepmc   +2 more sources

Pervasive effects of RNA degradation on Nanopore direct RNA sequencing. [PDF]

NAR Genom Bioinform, 2023
Oxford Nanopore direct RNA sequencing (DRS) is capable of sequencing complete RNA molecules and accurately measuring gene and isoform expression. However, as DRS is designed to profile intact RNA, expression quantification may be more heavily dependent ...
Prawer YDJ, Gleeson J, De Paoli-Iseppi R, Clark MB.   +3 more
europepmc   +2 more sources

Rixosomal RNA degradation contributes to silencing of Polycomb target genes. [PDF]

Nature, 2022
Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) are histone-modifying and -binding complexes that mediate the formation of facultative heterochromatin and are required for silencing of developmental genes and maintenance of cell fate1–3.
Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, Zhang J, Luo Z, Gygi SP, Adelman K, Moazed D.   +10 more
europepmc   +2 more sources

Impact of RNA degradation on next-generation sequencing transcriptome data

Genomics, 2022
RNA sequencing is an innovative technology to study transcriptomes in both biological and clinical research. However, clinical specimens from patients undergoing surgical operations have a major challenge due to sample degradation.
Wenxiang Lu, Qin Zhou, Yi Chen
exaly   +2 more sources