RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids
Cell Reports, 2019 Summary: RNA-DNA hybrids are tightly regulated to ensure genome integrity. The RNase H enzymes RNase H1 and H2 contribute to chromosomal stability through the removal of RNA-DNA hybrids.
Brian Luke +2 more
exaly +3 more sources
Bacterial Biodiversity of the Kapova Karst Cave as a Source of Hydrolases Producers
European Journal of Biology, 2023 Objective: Recent studies have revealed the biodiversity of both cultivated and uncultivated microbiomes in extreme environments. It has been shown that terrestrial subsurface ecosystems contain vast metabolic potential.
Willam Kurdy +2 more
doaj +1 more source
Evaluation of Ribonuclease (RNAse) Activity in the Sera of Women with Breast Tumor. [PDF]
Kirkuk Journal of Science, 2019 In this study 125 patients with breast tumors (61 patients with benign breast tumors, 64 patients with malignant breast tumors) with age range between (20-75) years collected from Center of Early Detection of Breast Cancer in Azady Teaching Hospital in ...
Basma Tawfeq, Kdiar Kdiar, Sabah Kurshid
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Enzymatic activity necessary to restore the lethality due to Escherichia coli RNase E deficiency is distributed among bacteria lacking RNase E homologues. [PDF]
PLoS ONE, 2017 Escherichia coli RNase E (Eco-RNase E), encoded by rne (Eco-rne), is considered the global RNA decay initiator. Although Eco-RNase E is an essential gene product in E.
Masaru Tamura +4 more
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Divalent metal ion-induced folding mechanism of RNase H1 from extreme halophilic archaeon Halobacterium sp. NRC-1. [PDF]
PLoS ONE, 2014 RNase H1 from Halobacterium sp. NRC-1 (Halo-RNase H1) is characterized by the abundance of acidic residues on the surface, including bi/quad-aspartate site residues.
Elias Tannous, Shigenori Kanaya
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Human RNase H1 is associated with protein P32 and is involved in mitochondrial pre-rRNA processing. [PDF]
PLoS ONE, 2013 Mammalian RNase H1 has been implicated in mitochondrial DNA replication and RNA processing and is required for embryonic development. We identified the mitochondrial protein P32 that binds specifically to human RNase H1, but not human RNase H2. P32 binds
Hongjiang Wu +4 more
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ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections
Viruses, 2021 Host response to a viral infection includes the production of type I interferon (IFN) and the induction of interferon-stimulated genes that have broad antiviral effects.
Barkha Ramnani +3 more
doaj +1 more source
Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L. [PDF]
PLoS Pathogens, 2013 Theiler's virus is a neurotropic picornavirus responsible for chronic infections of the central nervous system. The establishment of a persistent infection and the subsequent demyelinating disease triggered by the virus depend on the expression of L*, a ...
Frédéric Sorgeloos +3 more
doaj +1 more source
Cell Insight, 2023 R-loops are regulators of many cellular processes and are threats to genome integrity. Therefore, understanding the mechanisms underlying the regulation of R-loops is important.
Le Li +9 more
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RNase 7 contributes to the cutaneous defense against Enterococcus faecium. [PDF]
PLoS ONE, 2009 BackgroundHuman skin is able to mount a fast response against invading microorganisms by the release of antimicrobial proteins such as the ribonuclease RNase 7. Because RNase 7 exhibits high activity against Enterococcus faecium the aim of this study was
Bente Köten +5 more
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