Results 31 to 40 of about 365,508 (294)

Cytosolic RNase Inhibitor Only Affects RNases with Intrinsic Cytotoxicity [PDF]

Journal of Biological Chemistry, 2004
Cytosolic RNase inhibitor binds to and neutralizes most members of the pancreatic type RNase superfamily. However, there are a few exceptions, e.g. amphibian onconase and bovine seminal RNase, and these are endowed with cytotoxic activity. Also, RNase variants created by mutagenesis to partially evade the RNase inhibitor acquire cytotoxic activity ...
MONTI, DARIA MARIA, D'ALESSIO, GIUSEPPE
openaire   +5 more sources

Inhibition of antimicrobial resistance by RNase 3/1 chimeras in biofilm cultures of Acinetobacter baumannii

, 2023
reservedThe worldwide spread of bacterial resistance against conventional antibiotics motivates the development of novel antimicrobial drugs. Bacterial biofilms are highly present in the hospital setting and are responsible for several types of ...
CENERE, GIOVANNI
core  

Towards plant resistance to viruses using protein-only RNase P [PDF]

, 2021
International audiencePlant viruses cause massive crop yield loss worldwide. Most plant viruses are RNA viruses, many of which contain a functional tRNA-like structure.
Jupin, Isabelle, Da Silva, N. (Nathalie), Quan, Yifat, Cohen, Mathias, Arrive, Mathilde, Gobert, A. (Anthony), Jomat, L. (Lucile), Jupin, I. (Isabelle), Waltz, F. (Florent), Quan, Y. (Yifat), Cohen, M. (Mathias), Giege, P. (Philippe), Gobert, Anthony, Jomat, Lucile, Waltz, Florent, Giegé, Philippe, Arrive, M. (Mathilde), da Silva, Nathalie   +17 more
core   +1 more source

A structural model of pestivirus E(rns) based on disulfide bond connectivity and homology modeling reveals an extremely rare vicinal disulfide [PDF]

, 2002
Erns is a pestivirus envelope glycoprotein and is the only known viral surface protein with RNase activity. Erns is a disulfide-linked homodimer of 100 kDa; it is found on the surface of pestivirus-infected cells and is secreted into the medium.
Ru, A.H., de, Hulst, M.M., Schaaper, W.M.M., de Ru, A.H., van Veelen, P.A., Langedijk, J.P.M., Meloen, R.H., Veelen, P.A., van   +7 more
core   +1 more source

Transcriptome-wide analyses of 5'-ends in RNase J mutants of a gram-positive pathogen reveal a role in RNA maturation, regulation and degradation.

PLoS Genetics, 2014
RNA decay and maturation have in recent years been recognised as major regulatory mechanisms in bacteria. In contrast to Escherichia coli, the Firmicute (Gram-positive) bacteria often do not encode the well-studied endonuclease RNase E, but instead rely ...
Patrick Linder, Sylvain Lemeille, Peter Redder   +2 more
doaj   +1 more source

Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes. [PDF]

PLoS ONE, 2014
Ribonucleases belonging to the RNase T2 family are enzymes associated with the secretory pathway that are almost absolutely conserved in all eukaryotes.
Linda Ambrosio, Stephanie Morriss, Ayesha Riaz, Ryan Bailey, Jian Ding, Gustavo C MacIntosh   +5 more
doaj   +1 more source

Structural studies of nucleic acids and proteins involved in nucleic acid recognition [PDF]

, 2010
This PhD thesis focuses on the structural analysis of the protein-nucleic acid recognition. In particular the research work has been focalized on two different kinds of proteins and their nucleotide ligands.
Russo Krauss, Irene
core   +1 more source

Biochemical assessment of the effect of the antibiotic erythromycin on the river snail (Viviparus viviparus L.)

RUDN Journal of Ecology and Life Safety
The activity of the complex of acid deoxyribonucleases (DNases) and ribonucleases (RNases) of the hepatopancreas of the river snail ( Viviparus viviparus L.) was studied under normal conditions and under acute exposure to erythromycin. An increase in the
Ekaterina A. Tishina, Tatiana S. Droganova, Lyudmila V. Polikarpova, Andrew L. Petrov   +3 more
doaj   +1 more source

NaPi/SX-RNase segregates as a functional S-RNase and is induced under phosphate deficiency in Nicotiana alata

Biologia Plantarum, 2018
In plants, class III T2 RNases involves two groups of structurally similar proteins, but with different biological functions: S-RNases and non-S-RNases.
H. J. Rojas, C. Caspani, E. G. Escobar, R. Quiroga, A. Goldraij   +4 more
doaj   +1 more source

Structural and biochemical characteristics of two Staphylococcus epidermidis RNase J paralogs RNase J1 and RNase J2 [PDF]

Journal of Biological Chemistry, 2020
RNase J enzymes are metallohydrolases that are involved in RNA maturation and RNA recycling, govern gene expression in bacteria, and catalyze both exonuclease and endonuclease activity. The catalytic activity of RNase J is regulated by multiple mechanisms which include oligomerization, conformational changes to aid substrate recognition, and the metal ...
Raj R., Nadig S., Patel T., Gopal B.
openaire   +3 more sources