ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections
Viruses, 2021 Host response to a viral infection includes the production of type I interferon (IFN) and the induction of interferon-stimulated genes that have broad antiviral effects.
Barkha Ramnani +3 more
doaj +1 more source
RNase AS versus RNase T: Similar yet Different [PDF]
Structure, 2014 In this issue of Structure, Romano and colleagues show that RNase AS specifically hydrolyses adenylate-containing RNA and affects mycobacterial virulence. This study reveals the structural basis underlying the substrate specificity of this enzyme.
Tang, Xuhua +2 more
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Cytosolic RNase Inhibitor Only Affects RNases with Intrinsic Cytotoxicity [PDF]
Journal of Biological Chemistry, 2004 Cytosolic RNase inhibitor binds to and neutralizes most members of the pancreatic type RNase superfamily. However, there are a few exceptions, e.g. amphibian onconase and bovine seminal RNase, and these are endowed with cytotoxic activity. Also, RNase variants created by mutagenesis to partially evade the RNase inhibitor acquire cytotoxic activity ...
MONTI, DARIA MARIA, D'ALESSIO, GIUSEPPE
openaire +4 more sources
A novel mechanism of RNase L inhibition: Theiler\u27s virus L* protein prevents 2-5A from binding to RNase L [PDF]
, 2018 The OAS/RNase L pathway is one of the best-characterized effector pathways of the IFN antiviral response. It inhibits the replication of many viruses and ultimately promotes apoptosis of infected cells, contributing to the control of virus spread ...
Drappier, Melissa +8 more
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RNase 7 contributes to the cutaneous defense against Enterococcus faecium. [PDF]
PLoS ONE, 2009 BackgroundHuman skin is able to mount a fast response against invading microorganisms by the release of antimicrobial proteins such as the ribonuclease RNase 7. Because RNase 7 exhibits high activity against Enterococcus faecium the aim of this study was
Bente Köten +5 more
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Cationic poly(amidoamine) promotes cytosolic delivery of bovine RNase A in melanoma cells, while maintaining its cellular toxicity [PDF]
, 2015 Ribonucleases are known to cleave ribonucleic acids, inducing cell death. RNase A, a member of the ribonuclease family, generally displayed poor in vitro activity. This has been attributed to factors such as low intracellular delivery.
Akinc +60 more
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Scientia Marina, 2005 Extraction procedures for RNA and DNA in crude extracts of natural microplankton samples are developed. The methodology is compatible with the fluorometric assay of RNA and DNA developed by Berdalet et al. (2005).
Elisa Berdalet +2 more
doaj +1 more source
Structural basis for dual roles of Aar2p in U5 snRNP assembly [PDF]
, 2013 Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase.
Beggs, J.D. +8 more
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Scientia Marina, 2005 Assay protocols for RNA and DNA in crude plankton extracts using the fluorochrome SYBR Green II are developed here. The method is based on the fluorescence in 3 aliquots: the first measures RNA after DNA digestion; the second measures DNA after RNA ...
Elisa Berdalet +3 more
doaj +1 more source
Lineage A betacoronavirus NS2 proteins and the homologous torovirus Berne pp1a carboxy-terminal domain are phosphodiesterases that antagonize activation of RNase L [PDF]
, 2017 Viruses in the family Coronaviridae, within the order Nidovirales, are etiologic agents of a range of human and animal diseases, including both mild and severe respiratory diseases in humans.
Chen, Annie I +9 more
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