Results 11 to 20 of about 962,124 (298)
Technologies for Targeted RNA Degradation and Induced RNA Decay. [PDF]
Chem RevThe vast majority of the human genome codes for RNA, but RNA-targeting therapeutics account for a small fraction of approved drugs. As such, there is great incentive to improve old and develop new approaches to RNA targeting. For many RNA targeting modalities, just binding is not sufficient to exert a therapeutic effect; thus, targeted RNA degradation ...
Mikutis S, Bernardes GJL.
europepmc +4 more sources
The Many Pathways of RNA Degradation [PDF]
Cell, 2009 From the earliest comparisons of RNA production with steady-state levels, it has been clear that cells transcribe more RNA than they accumulate, implying the existence of active RNA degradation systems. In general, RNA is degraded at the end of its useful life, which is long for a ribosomal RNA but very short for excised introns or spacer fragments ...
Jonathan Houseley, David Tollervey
exaly +3 more sources
RNA polymerase promotes splicing, prevents degradation. [PDF]
PLoS Biology, 2006 As it rolls off the DNA assembly line, RNA faces an uncertain fate. Down one path lies further processing and, ultimately, translation into protein. Down the other, though, lies oblivion—degradation by RNA-digesting enzymes, and recycling back into the nucleotides from which it came.
Richard Robinson
doaj +4 more sources
RNA‐PROTACs: Degraders of RNA‐Binding Proteins [PDF]
Angewandte Chemie International Edition, 2020 AbstractDefects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases; however, targeting RBPs with conventional drugs has proven difficult. PROTACs are a new class of drugs that mediate selective degradation of a target protein through a cell's ubiquitination machinery.
Alice Ghidini +4 more
openaire +4 more sources
Pervasive effects of RNA degradation on Nanopore direct RNA sequencing. [PDF]
NAR Genom Bioinform, 2023 Abstract Oxford Nanopore direct RNA sequencing (DRS) is capable of sequencing complete RNA molecules and accurately measuring gene and isoform expression. However, as DRS is designed to profile intact RNA, expression quantification may be more heavily dependent upon RNA integrity than alternative RNA sequencing methodologies.
Prawer YDJ +3 more
europepmc +4 more sources
Rixosomal RNA degradation contributes to silencing of Polycomb target genes. [PDF]
Nature, 2022 Zhou H +10 more
europepmc +2 more sources
Plants, 2020 RNA quality control is an indispensable but poorly understood process that enables organisms to distinguish functional RNAs from nonfunctional or inhibitory ones.
Amber M. Hotto +2 more
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A model explaining mRNA level fluctuations based on activity demands and RNA age.
PLoS Computational Biology, 2021 Cellular RNA levels typically fluctuate and are influenced by different transcription rates and RNA degradation rates. However, the understanding of the fundamental relationships between RNA abundance, environmental stimuli, RNA activities, and RNA age ...
Zhongneng Xu, Shuichi Asakawa
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RNA Quality Control Using External Standard RNA [PDF]
Polish Journal of Microbiology, 2018 In this paper, we propose a new evaluation method using external standard RNA for quality control of the extracted RNA. RNA Integrity Number and UV absorption are generally used as a basis for RNA quality control; however, these methods do not always ...
HITOSHI IWAHASHI +2 more
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SARS-CoV-2 Nsp1 mediated mRNA degradation requires mRNA interaction with the ribosome
RNA Biology, 2023 Nsp1 is a SARS-CoV-2 host shutoff factor that both represses cellular translation and promotes host RNA decay. However, it is unclear how these two activities are connected and interact with normal translation processes.
Soraya I. Shehata, Roy Parker
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