Results 11 to 20 of about 5,666,730 (325)
RNA degradation in Saccharomyces cerevisae. [PDF]
Genetics, 2012 All RNA species in yeast cells are subject to turnover. Work over the past 20 years has defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs, and noncoding RNAs.
Roy Parker
exaly +4 more sources
TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV. [PDF]
Nat Commun, 2022 The Human Silencing Hub (HUSH) complex constituted of TASOR, MPP8 and Periphilin recruits the histone methyl-transferase SETDB1 to spread H3K9me3 repressive marks across genes and transgenes in an integration site-dependent manner.
Matkovic R +11 more
europepmc +2 more sources
A Genetic Circuit Design for Targeted Viral RNA Degradation [PDF]
Bioengineering, 2023 Advances in synthetic biology have led to the design of biological parts that can be assembled in different ways to perform specific functions. For example, genetic circuits can be designed to execute specific therapeutic functions, including gene ...
Adebayo J. Bello +4 more
doaj +2 more sources
bioRxiv, 2023 Polycomb repressive complex 2 (PRC2) modifies chromatin to maintain repression of genes specific for other cell lineages and is essential for development.
Hickman AH, Jenner RG.
europepmc +2 more sources
Transcriptome maps of general eukaryotic RNA degradation factors
eLife, 2019 RNA degradation pathways enable RNA processing, the regulation of RNA levels, and the surveillance of aberrant or poorly functional RNAs in cells. Here we provide transcriptome-wide RNA-binding profiles of 30 general RNA degradation factors in the yeast ...
Salma Sohrabi-Jahromi +7 more
doaj +2 more sources
RNA Degradation in Pluripotent Stem Cells: Mechanisms, Crosstalk, and Fate Regulation [PDF]
CellsPluripotent stem cells (PSCs) exhibit remarkable self-renewal capacity and differentiation potential, necessitating tight regulation of gene expression at both transcriptional and post-transcriptional levels.
Seunghwa Jeong +3 more
doaj +2 more sources
CRISPR/CasRx Proof-of-Concept for RNA Degradation: A Future Tool against RNA Viruses? [PDF]
Pharmaceuticals, 2021 Influenza viruses provide a great threat for the human population, causing highly contagious respiratory infections that can lead to serious clinical complications.
Diana Perez-SanJose +5 more
doaj +2 more sources
meCLICK-Seq, a Substrate-Hijacking and RNA Degradation Strategy for the Study of RNA Methylation. [PDF]
ACS Cent Sci, 2020 The fates of RNA species in a cell are controlled by ribonucleases, which degrade them by exploiting the universal structural 2′-OH group. This phenomenon plays a key role in numerous transformative technologies, for example, RNA interference and CRISPR ...
Mikutis S +9 more
europepmc +2 more sources
RNA Degradation in Neurodegenerative Disease [PDF]
Advances in neurobiology, 2018 Ribonucleic acid (RNA) homeostasis is dynamically modulated in response to changing physiological conditions. Tight regulation of RNA abundance through both transcription and degradation determines the amount, timing, and location of protein translation.
Kaitlin Weskamp, S. Barmada
semanticscholar +3 more sources
NUDT2 initiates viral RNA degradation by removal of 5′-phosphates [PDF]
Nature Communications, 2021 RNA of some viruses is protected from degradation by a 5′ triphosphate group. Here the authors identify nudix hydrolase 2 (NUDT2) as novel antiviral defense protein that dephosphorylates viral RNA and thereby enables its degradation.
Beatrice T. Laudenbach +14 more
doaj +2 more sources