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Viruses, 2022 This review is an accompaniment to a Special Issue on “Retroviral RNA Processing”. It discusses post-transcriptional regulation of retroviruses, ranging from the ancient foamy viruses to more modern viruses, such as HIV-1, HTLV-1, Rous sarcoma virus ...
Karen L. Beemon
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HibeRNAtion: HIV-1 RNA Metabolism and Viral Latency
Frontiers in Cellular and Infection Microbiology, 2022 HIV-1 infection remains non-curative due to the latent reservoir, primarily a small pool of resting memory CD4+ T cells bearing replication-competent provirus.
Raquel Crespo +4 more
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Cytoplasmic mRNA recapping has limited impact on proteome complexity [PDF]
Open Biology, 2020 The m7G cap marks the 5′ end of all eukaryotic mRNAs, but there are also capped ends that map downstream within spliced exons. A portion of the mRNA transcriptome undergoes a cyclical process of decapping and recapping, termed cap homeostasis, which ...
Bernice A. Agana +2 more
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Surveillance-ready transcription: nuclear RNA decay as a default fate [PDF]
Open Biology, 2018 Eukaryotic cells synthesize enormous quantities of RNA from diverse classes, most of which are subject to extensive processing. These processes are inherently error-prone, and cells have evolved robust quality control mechanisms to selectively remove ...
Stefan Bresson, David Tollervey
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MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer [PDF]
Open Biology, 2013 The ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA ...
Timothy M. Johanson +2 more
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CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures [PDF]
Open Biology, 2020 Eukaryotic messenger RNA (mRNA) is modified by the addition of an inverted guanosine cap to the 5′ triphosphate. The cap guanosine and initial transcribed nucleotides are further methylated by a series of cap methyltransferases to generate the mature cap
Alison Galloway +5 more
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Adipocyte, 2021 Adipogenesis is regulated by genetic interactions, in which post-transcriptional regulation plays an important role. Staufen double-stranded RNA binding protein 1 (Staufen1 or STAU1) plays diverse roles in RNA processing and adipogenesis.
Xiaodi Liang +7 more
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RNA Processing Marches on [PDF]
Cell, 2000 We would like to thank the many colleagues who contributed unpublished data and helpful comments. We apologize to those whose work could not be fully referenced due to space limitations. D. T. was supported by the Wellcome Trust. J. F. C. was supported by the MRC.
Tollervey, David, Caceres, Javier F
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Biology Open, 2022 Mature transfer (t)RNAs are generated by multiple RNA processing events, which can include the excision of intervening sequences. The tRNA splicing endonuclease (TSEN) complex is responsible for cleaving these intron-containing pre-tRNA transcripts.
Casey A. Schmidt +6 more
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RNA Processing and Export [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript.
Sami, Hocine +2 more
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