Results 21 to 30 of about 3,563,841 (257)

RNA-specific ribonucleotidyl transferases [PDF]

, 2007
RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W., Martin, G., W. Keller, G. Martin   +3 more
core   +1 more source

FUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications

Scientific Reports, 2023
FUS is a multifunctional protein involved in many aspects of RNA metabolism, including transcription, splicing, translation, miRNA processing, and replication-dependent histone gene expression.
Kishor Gawade, Patrycja Plewka, Sophia J. Häfner, Anders H. Lund, Virginie Marchand, Yuri Motorin, Michal W. Szczesniak, Katarzyna D. Raczynska   +7 more
doaj   +1 more source

Comprehensive Characterization of RNA Processing Factors in Gastric Cancer Identifies a Prognostic Signature for Predicting Clinical Outcomes and Therapeutic Responses

Frontiers in Immunology, 2021
RNA processing converts primary transcript RNA into mature RNA. Altered RNA processing drives tumor initiation and maintenance, and may generate novel therapeutic opportunities.
Shenghan Lou, Fanzheng Meng, Xin Yin, Yao Zhang, Bangling Han, Yingwei Xue   +5 more
doaj   +1 more source

An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]

, 2007
RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid, Stuart, Kenneth, Ernst, Nancy Lewis, Fleck, Michele, Babbarwal, Vinod Kumar   +4 more
core   +1 more source

Trim25 is an RNA-specific activator of Lin28a/TuT4-mediated uridylation [PDF]

, 2014
RNA binding proteins have thousands of cellular RNA targets and often exhibit opposite or passive molecular functions. Lin28a is a conserved RNA binding protein involved in pluripotency and tumorigenesis that was previously shown to trigger TuT4-mediated
Nowak, Jakub S., Roy Choudhury, Nila, Rappsilber, Juri, Spoel, Steven H, Nila Roy Choudhury, Nowak, Jakub S, Zuo, Juan, Michlewski, Gracjan, Juan Zuo, Juri Rappsilber, Choudhury, Nila Roy, Steven H. Spoel, Gracjan Michlewski, Jakub S. Nowak, Spoel, Steven H.   +14 more
core   +1 more source

Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway [PDF]

, 2012
tRNA precursors, which are transcribed by RNA polymerase III, undergo end-maturation, splicing and base modifications. Hypomodified tRNAs, such as tRNAVal(AAC), lacking 7-methylguanosine and 5-methylcytidine modifications, are subject to degradation by a
Boguta, Magdalena, Turowski, Tomasz W., Karkusiewicz, Iwona, Kowal, J   +3 more
core   +1 more source

CDK12 Activity-Dependent Phosphorylation Events in Human Cells

Biomolecules, 2019
We asked whether the C-terminal repeat domain (CTD) kinase, CDK12/CyclinK, phosphorylates substrates in addition to the CTD of RPB1, using our CDK12analog-sensitive HeLa cell line to investigate CDK12 activity-dependent phosphorylation events in human ...
Bartlomiej Bartkowiak, Christopher M. Yan, Erik J. Soderblom, Arno L. Greenleaf   +3 more
doaj   +1 more source

Repositioning the Sm-Binding Site in Saccharomyces cerevisiae Telomerase RNA Reveals RNP Organizational Flexibility and Sm-Directed 3′-End Formation

Non-Coding RNA, 2020
Telomerase RNA contains a template for synthesizing telomeric DNA and has been proposed to act as a flexible scaffold for holoenzyme protein subunits in the RNP.
Evan P. Hass, David C. Zappulla
doaj   +1 more source

ReadZS detects cell type-specific and developmentally regulated RNA processing programs in single-cell RNA-seq

Genome Biology, 2022
RNA processing, including splicing and alternative polyadenylation, is crucial to gene function and regulation, but methods to detect RNA processing from single-cell RNA sequencing data are limited by reliance on pre-existing annotations, peak calling ...
Elisabeth Meyer, Kaitlin Chaung, Roozbeh Dehghannasiri, Julia Salzman   +3 more
doaj   +1 more source

Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]

, 2007
A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David, Dlakic, Mensur, Dez, Christophe   +2 more
core   +1 more source