Dynamic signal processing by ribozyme-mediated RNA circuits to control gene expression [PDF]
, 2014 Organisms have different circuitries that allow converting signal molecule levels to changes in gene expression. An important challenge in synthetic biology involves the de novo design of RNA modules enabling dynamic signal processing in live cells. This
Satya Prakash +21 more
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Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]
, 2013 Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Richard M. Elliott +16 more
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The Crosstalk Between Epigenetic Mechanisms and Alternative RNA Processing Regulation
Frontiers in Genetics, 2020 As a co-transcriptional process, RNA processing, including alternative splicing and alternative polyadenylation, is crucial for the generation of multiple mRNA isoforms.
Jian Zhang +6 more
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3 '-processing of yeast tRNA(Trp) precedes 5 '-processing [PDF]
, 2003 Previous analyses of eukaryotic pre-tRNAs processing have reported that 5'-cleavage by RNase P precedes 3'-maturation. Here we report that in contrast to all other yeast tRNAs analyzed to date, tRNA(Trp) undergoes 3'-maturation prior to 5'-cleavage ...
Tollervey, D, Kufel, J
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An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]
, 2013 Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Darren M. Gowers (485354) +29 more
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RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components [PDF]
, 2004 Sequential events in macromolecular biosynthesis are often elegantly coordinated. The small ribosomal subunit (SSU) processome is a large ribonucleoprotein (RNP) required for processing of precursors to the small subunit RNA, the 18S, of the ribosome. We
Granneman, Sander; id_orcid +6 more
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Telomere maintenance: regulating hTERC fate through RNA modifications
Molecular & Cellular Oncology, 2019 Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC ...
Lisa Lirussi, Hilde Nilsen
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Mechanistic insights into non-coding Y RNA processing
RNA Biology, 2022 Y RNAs (84–112 nt) are non-coding RNAs transcribed by RNA polymerase III and are characterized by a distinctive secondary structure. Human Y RNAs interact with the autoimmune proteins SSB and RO60 that together form a ribonucleoprotein (RNP) complex ...
Martina Billmeier +7 more
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The function of the protein phosphatase Glc7p in transcription termination, RNA processing and transcriptional regulation of ribosomal protein genes [PDF]
, 2007 Gene transcription in general can be subdivided into three main phases: transcription initiation, elongation and termination. The enzyme that accomplishes transcription of protein coding genes, snRNAs and snoRNAs is RNA polymerase II (RNAP II).
Röck, Salome
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Signal Processing Methods for Genomic Sequence Analysis [PDF]
, 2007 Signal processing is the art of representing, transforming, analyzing, and manipulating signals. It deals with a wide range of signals, from speech and audio signals to images and video signals, and many others.
Yoon, Byung-Jun
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