Results 41 to 50 of about 691,582 (312)

Signal Processing Methods for Genomic Sequence Analysis [PDF]

, 2007
Signal processing is the art of representing, transforming, analyzing, and manipulating signals. It deals with a wide range of signals, from speech and audio signals to images and video signals, and many others.
Yoon, Byung-Jun
core   +1 more source

Mechanistic insights into non-coding Y RNA processing

RNA Biology, 2022
Y RNAs (84–112 nt) are non-coding RNAs transcribed by RNA polymerase III and are characterized by a distinctive secondary structure. Human Y RNAs interact with the autoimmune proteins SSB and RO60 that together form a ribonucleoprotein (RNP) complex ...
Martina Billmeier, Darrell Green, Adam E. Hall, Carly Turnbull, Archana Singh, Ping Xu, Simon Moxon, Tamas Dalmay   +7 more
doaj   +1 more source

Identification of human mitochondrial RNA cleavage sites and candidate RNA processing factors

BMC Biology, 2022
Background The human mitochondrial genome is transcribed as long strands of RNA containing multiple genes, which require post-transcriptional cleavage and processing to release functional gene products that play vital roles in cellular energy production.
Guillermo Carbajosa, Aminah T. Ali, Alan Hodgkinson   +2 more
doaj   +1 more source

In vivo nuclear RNA structurome reveals RNA-structure regulation of mRNA processing in plants

Genome Biology, 2021
Background mRNA processing is critical for gene expression. A challenge in regulating mRNA processing is how to recognize the actual mRNA processing sites, such as splice and polyadenylation sites, when the sequence content is insufficient for this ...
Zhenshan Liu, Qi Liu, Xiaofei Yang, Yueying Zhang, Matthew Norris, Xiaoxi Chen, Jitender Cheema, Huakun Zhang, Yiliang Ding   +8 more
doaj   +1 more source

Fast Processing RNA-Seq on Multicore Processor

مجلة بغداد للعلوم, 2021
RNA Sequencing (RNA-Seq) is the sequencing and analysis of transcriptomes. The main purpose of RNA-Seq analysis is to find out the presence and quantity of RNA in an experimental sample under a specific condition.
Lee Jia Bin, Nor Asilah Wati Abdul Hamid, Zurita Ismail, Mohamed Faris Laham   +3 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

RNA regulation of epigenetic processes [PDF]

BioEssays, 2009
AbstractThere is increasing evidence that dynamic changes to chromatin, chromosomes and nuclear architecture are regulated by RNA signalling. Although the precise molecular mechanisms are not well understood, they appear to involve the differential recruitment of a hierarchy of generic chromatin modifying complexes and DNA methyltransferases to ...
Mattick, J. S, Amaral, P. P., Dinger, M. E., Mercer, T. R., Mehler, M. F.   +4 more
openaire   +5 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Transcriptional termination enhances protein expression in human cells [PDF]

, 2009
Transcriptional termination of mammalian RNA polymerase II (Pol II) requires a poly(A) (pA) signal and, often, a downstream terminator sequence. Termination is triggered following recognition of the pA signal by Pol II and subsequent pre-mRNA cleavage ...
Proudfoot, Nicholas J, West, S, Proudfoot, NJ, West, Steven, Proudfoot, Nicholas   +4 more
core   +1 more source