A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies [PDF]
Nature CommunicationsRNA decay is vital for regulating mRNA abundance and gene expression. Existing technologies lack the spatiotemporal precision or transcript specificity to capture the stochastic and transient decay process.
Lauren A. Blake +4 more
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Integrated renal histopathology, RNA decay, and protein degradation signatures enhance post-mortem interval prediction using machine-learning models in a veterinary forensic rat model [PDF]
Veterinary WorldBackground and Aim: Accurate estimation of post-mortem interval (PMI) is essential in veterinary forensics for reconstructing events surrounding death and supporting legal, welfare, and biosecurity investigations. Traditional methods relying on gross and
Om Prakash Choudhary +2 more
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Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress [PDF]
eLifeCells react to stress by triggering response pathways, leading to extensive alterations in the transcriptome to restore cellular homeostasis. The role of RNA metabolism in shaping the cellular response to stress is vital, yet the global changes in RNA ...
Showkat Ahmad Dar +9 more
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Environmental and microbial factors shaping SARS-CoV-2 RNA decay in wastewater: insights from batch tests and a lab-scale sewer pipeline simulator [PDF]
Scientific ReportsWastewater-based surveillance (WBS) can provide early warning of outbreaks, but wastewater RNA signals may be underestimated due to analytical limitations and in-sewer attenuation driven by matrix conditions and conveyance.
JooAhn Jung +3 more
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UPF1-Mediated RNA Decay—Danse Macabre in a Cloud
Biomolecules, 2020 Nonsense-mediated RNA decay (NMD) is the prototype example of a whole family of RNA decay pathways that unfold around a common central effector protein called UPF1.
Daria Lavysh, Gabriele Neu-Yilik
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The zinc finger protein ZFP36L2 inhibits flavivirus infection via the 5′-3′ XRN1-mediated RNA decay pathway in the replication complexes [PDF]
Journal of Biomedical ScienceBackground The zinc finger protein 36-like (ZFP36L) family is a CCCH-type group consisting of RNA-binding proteins, i.e., ZFP36L1 and ZFP36L2, which regulate cellular mRNA through the RNA decay pathway. ZFP36L1 combats flavivirus infections through the 5′
Ren-Jye Lin +5 more
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RNA decay and RNA silencing in plants: competition or collaboration?
Frontiers in Plant Science, 2011 Initiation of RNA polymerase II transcription signals the beginning of a series of physically and functionally coupled pre-mRNA processing events that transform an RNA transcript into a highly structured, mature ribonucleoprotein complex.
Michael eChristie +3 more
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Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells [PDF]
Frontiers in EndocrinologyIntroductionProinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components.
Seyed M. Ghiasi +12 more
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Attacked from All Sides: RNA Decay in Antiviral Defense
Viruses, 2017 The innate immune system has evolved a number of sensors that recognize viral RNA (vRNA) to restrict infection, yet the full spectrum of host-encoded RNA binding proteins that target these foreign RNAs is still unknown.
Jerome M. Molleston, Sara Cherry
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Nonsense-mediated RNA decay: an emerging modulator of malignancy [PDF]
Nature Reviews Cancer, 2022 Miles Wilkinson +2 more
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