Technologies for Targeted RNA Degradation and Induced RNA Decay. [PDF]
Chem RevThe vast majority of the human genome codes for RNA, but RNA-targeting therapeutics account for a small fraction of approved drugs. As such, there is great incentive to improve old and develop new approaches to RNA targeting. For many RNA targeting modalities, just binding is not sufficient to exert a therapeutic effect; thus, targeted RNA degradation ...
Mikutis S, Bernardes GJL.
europepmc +5 more sources
Genome‐wide study of mRNA degradation and transcript elongation in Escherichia coli [PDF]
Molecular Systems Biology, 2015 An essential part of gene expression is the coordination of RNA synthesis and degradation, which occurs in the same cellular compartment in bacteria.
Huiyi Chen +3 more
doaj +3 more sources
Viruses and the cellular RNA decay machinery. [PDF]
WIREs RNA, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +6 more sources
Cytoplasmic RNA decay pathways - enzymes and mechanisms [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016 RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work conducted over the last decades has defined the major mRNA decay pathways, as well as enzymes and their cofactors responsible for these processes. In contrast, our
Dziembowski, Andrzej +2 more
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Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress [PDF]
eLifeCells react to stress by triggering response pathways, leading to extensive alterations in the transcriptome to restore cellular homeostasis. The role of RNA metabolism in shaping the cellular response to stress is vital, yet the global changes in RNA ...
Showkat Ahmad Dar +9 more
doaj +2 more sources
A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies [PDF]
Nature CommunicationsRNA decay is vital for regulating mRNA abundance and gene expression. Existing technologies lack the spatiotemporal precision or transcript specificity to capture the stochastic and transient decay process.
Lauren A. Blake +4 more
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The zinc finger protein ZFP36L2 inhibits flavivirus infection via the 5′-3′ XRN1-mediated RNA decay pathway in the replication complexes [PDF]
Journal of Biomedical ScienceBackground The zinc finger protein 36-like (ZFP36L) family is a CCCH-type group consisting of RNA-binding proteins, i.e., ZFP36L1 and ZFP36L2, which regulate cellular mRNA through the RNA decay pathway. ZFP36L1 combats flavivirus infections through the 5′
Ren-Jye Lin +5 more
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RNA decay and RNA silencing in plants: competition or collaboration? [PDF]
Frontiers in Plant Science, 2011 Initiation of RNA polymerase II transcription signals the beginning of a series of physically and functionally coupled pre-mRNA processing events that transform an RNA transcript into a highly structured, mature ribonucleoprotein complex.
Michael eChristie +3 more
doaj +4 more sources
UPF1-Mediated RNA Decay—Danse Macabre in a Cloud [PDF]
Biomolecules, 2020 Nonsense-mediated RNA decay (NMD) is the prototype example of a whole family of RNA decay pathways that unfold around a common central effector protein called UPF1.
Daria Lavysh, Gabriele Neu-Yilik
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In vitro RNA Cleavage Assays to Characterize IRE1-dependent RNA Decay [PDF]
Bio-Protocol, 2019 The kinase/RNase IRE1 is a key effector of the cellular response to endoplasmic reticulum stress. The RNase activity of IRE1 can be measured in cells or in the test tube.
G. Karagöz +3 more
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