Cellular variability of nonsense-mediated mRNA decay [PDF]
Nature Communications, 2021 Here the author developed a single-cell reporter system to identify cell-to-cell variability of nonsense-mediated mRNA decay (NMD). This approach provides a sensitive tool to investigate cellular heterogeneity of NMD in various physiological conditions.
Hanae Sato, Robert H. Singer
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Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism [PDF]
Biomedicines, 2022 Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes.
Fabrice Lejeune
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Nonsense-Mediated mRNA Decay as a Mediator of Tumorigenesis. [PDF]
Genes (Basel), 2023 Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved and well-characterized biological mechanism that ensures the fidelity and regulation of gene expression.
Nagar P, Islam MR, Rahman MA.
europepmc +4 more sources
Nonsense-Mediated mRNA Decay Factor Functions in Human Health and Disease [PDF]
Biomedicines, 2023 Nonsense-mediated mRNA decay (NMD) is a cellular surveillance mechanism that degrades mRNAs with a premature stop codon, avoiding the synthesis of C-terminally truncated proteins. In addition to faulty mRNAs, NMD recognises ~10% of endogenous transcripts
Lingling Sun +2 more
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Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay [PDF]
Nature Communications, 2016 Gene expression is regulated by a range of mechanisms, including post-translational modifications such as phosphorylation. Here the authors present evidence for a feedback mechanism whereby hyperphosphorylation of UPF1 in response to delays in nonsense ...
Sébastien Durand +2 more
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Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP [PDF]
Nature Communications, 2019 The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1.
Manjeera Gowravaram +4 more
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SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
Nature Communications, 2021 Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation.
Volker Boehm +8 more
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Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses [PDF]
Viruses, 2023 The virus–host interaction is dynamic and evolutionary. Viruses have to fight with hosts to establish successful infection. Eukaryotic hosts are equipped with multiple defenses against incoming viruses.
Md Robel Ahmed, Zhiyou Du
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Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System [PDF]
Biomedicines, 2023 Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that degrades mRNAs carrying a premature termination codon. Its inhibition, alone or in combination with other approaches, could be exploited to develop therapies for genetic diseases ...
Julie Carrard +11 more
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Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay [PDF]
Viruses, 2017 Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA ((+)RNA) viruses.
Giuseppe Balistreri +2 more
doaj +4 more sources