Results 1 to 10 of about 2,306,587 (203)
The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD). [PDF]
Pathogens, 2020 Before the establishment of an adaptive immune response, retroviruses can be targeted by several cellular host factors at different stages of the viral replication cycle. This intrinsic immunity relies on a large diversity of antiviral processes. In the case of HTLV-1 infection, these active innate host defense mechanisms are debated.
Prochasson L, Jalinot P, Mocquet V.
europepmc +7 more sources
Nonsense-Mediated mRNA Decay Factor Functions in Human Health and Disease
Biomedicines, 2023 Nonsense-mediated mRNA decay (NMD) is a cellular surveillance mechanism that degrades mRNAs with a premature stop codon, avoiding the synthesis of C-terminally truncated proteins. In addition to faulty mRNAs, NMD recognises ~10% of endogenous transcripts
Lingling Sun +2 more
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Nonsense-mediated mRNA decay: a key regulatory system engaged in cancer [PDF]
Cell Communication and SignalingNonsense-mediated mRNA decay (NMD) is a critical cellular surveillance mechanism that prevents the translation of defective or deleterious proteins. The regulation of NMD, including both its activation and the evasion of its target mRNA, is intricately ...
Hongyu Pan +5 more
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A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay. [PDF]
PLoS ONE, 2017 The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs containing premature termination codons, limiting the expression of potentially deleterious truncated proteins.
Stacey L Baker, J Robert Hogg
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SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
Nature Communications, 2021 Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation.
Volker Boehm +8 more
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Cellular variability of nonsense-mediated mRNA decay
Nature Communications, 2021 Here the author developed a single-cell reporter system to identify cell-to-cell variability of nonsense-mediated mRNA decay (NMD). This approach provides a sensitive tool to investigate cellular heterogeneity of NMD in various physiological conditions.
Hanae Sato, Robert H. Singer
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Genome Biology, 2021 Background Alternative splicing, which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression.
Carrie Kovalak +4 more
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PLoS ONE, 2023 A common cause of frontotemporal dementia (FTD) are nonsense mutations in the progranulin (GRN) gene. Because nonsense mutations activate the nonsense-mediated RNA decay (NMD) pathway, we sought to inhibit this RNA turnover pathway as a means to increase
Denise M. Smith +7 more
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Recoding of Nonsense Mutation as a Pharmacological Strategy
Biomedicines, 2023 Approximately 11% of genetic human diseases are caused by nonsense mutations that introduce a premature termination codon (PTC) into the coding sequence. The PTC results in the production of a potentially harmful shortened polypeptide and activation of a
Gazmend Temaj +5 more
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CLK-2/TEL2 is a conserved component of the nonsense-mediated mRNA decay pathway.
PLoS ONE, 2021 Nonsense-mediated mRNA decay (NMD) controls eukaryotic mRNA quality, inducing the degradation of faulty transcripts. Key players in the NMD pathway were originally identified, through genetics, in Caenorhabditis elegans as smg (suppressor with ...
Yanwu Guo +2 more
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