Results 1 to 10 of about 17,359 (221)

Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay [PDF]

Viruses, 2017
Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA ((+)RNA) viruses.
Giuseppe Balistreri, Claudia Bognanni, Oliver Mühlemann   +2 more
doaj   +4 more sources

Nonsense-Mediated mRNA Decay: Mechanisms and Recent Implications in Cardiovascular Diseases [PDF]

Cells
This review highlights the emerging functional implications of nonsense-mediated mRNA decay (NMD) in human diseases, with a focus on its therapeutic potential for cardiovascular disease.
Fasilat Oluwakemi Hassan, Md Monirul Hoque, Abdul Majid, Joy Olaoluwa Gbadegoye, Amr Raafat, Djamel Lebeche   +5 more
doaj   +2 more sources

Stop codon context modulates NMD efficiency through translation termination kinetics [PDF]

Cell Genomics
Nonsense-mediated mRNA decay efficiency varies unpredictably across transcripts containing premature termination codons. A new study by Kolakada et al.1 demonstrates that glycine residues preceding stop codons create an extended translation termination ...
Dasa Longman, Laura Monaghan, Javier F. Cáceres   +2 more
doaj   +2 more sources

Nonsense-mediated mRNA decay: a key regulatory system engaged in cancer [PDF]

Cell Communication and Signaling
Nonsense-mediated mRNA decay (NMD) is a critical cellular surveillance mechanism that prevents the translation of defective or deleterious proteins. The regulation of NMD, including both its activation and the evasion of its target mRNA, is intricately ...
Hongyu Pan, Xinyu Wu, Bingshuang Hu, Huihua Xiong, Yao Luo, Jian-Kang Zhou   +5 more
doaj   +2 more sources

A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay. [PDF]

PLoS ONE, 2017
The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs containing premature termination codons, limiting the expression of potentially deleterious truncated proteins.
Stacey L Baker, J Robert Hogg
doaj   +1 more source

SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

Nature Communications, 2021
Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation.
Volker Boehm, Sabrina Kueckelmann, Jennifer V. Gerbracht, Sebastian Kallabis, Thiago Britto-Borges, Janine Altmüller, Marcus Krüger, Christoph Dieterich, Niels H. Gehring   +8 more
doaj   +1 more source

Cellular variability of nonsense-mediated mRNA decay

Nature Communications, 2021
Here the author developed a single-cell reporter system to identify cell-to-cell variability of nonsense-mediated mRNA decay (NMD). This approach provides a sensitive tool to investigate cellular heterogeneity of NMD in various physiological conditions.
Hanae Sato, Robert H. Singer
doaj   +1 more source

Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. [PDF]

, 2016
Many gene expression factors contain repetitive phosphorylation sites for single kinases, but the functional significance is poorly understood. Here we present evidence for hyperphosphorylation as a mechanism allowing UPF1, the central factor in nonsense-
Durand, Sébastien, Franks, Tobias M, Lykke-Andersen, Jens   +2 more
core   +7 more sources

Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways

Genome Biology, 2021
Background Alternative splicing, which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression.
Carrie Kovalak, Scott Donovan, Alicia A. Bicknell, Mihir Metkar, Melissa J. Moore   +4 more
doaj   +1 more source

Targeting nonsense-mediated RNA decay does not increase progranulin levels in the GrnR493X mouse model of frontotemporal dementia

PLoS ONE, 2023
A common cause of frontotemporal dementia (FTD) are nonsense mutations in the progranulin (GRN) gene. Because nonsense mutations activate the nonsense-mediated RNA decay (NMD) pathway, we sought to inhibit this RNA turnover pathway as a means to increase
Denise M. Smith, Michael L. Niehoff, Karen Ling, Paymaan Jafar-Nejad, Frank Rigo, Susan A. Farr, Miles F. Wilkinson, Andrew D. Nguyen   +7 more
doaj   +3 more sources