Cellular variability of nonsense-mediated mRNA decay [PDF]
Nature Communications, 2021 Here the author developed a single-cell reporter system to identify cell-to-cell variability of nonsense-mediated mRNA decay (NMD). This approach provides a sensitive tool to investigate cellular heterogeneity of NMD in various physiological conditions.
Hanae Sato, Robert H. Singer
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Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay [PDF]
Nature Communications, 2016 Gene expression is regulated by a range of mechanisms, including post-translational modifications such as phosphorylation. Here the authors present evidence for a feedback mechanism whereby hyperphosphorylation of UPF1 in response to delays in nonsense ...
Sébastien Durand +2 more
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Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1 [PDF]
Molecular Therapy: Nucleic Acids, 2023 Neurofibromatosis type 1 (NF1) results from germline mutations in the tumor-suppressor gene NF1 and predisposes patients to developing nervous system tumors.
Sara H. Osum +12 more
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RNA virus evasion of nonsense-mediated decay.
PLoS Pathogens, 2018 Nonsense-mediated decay (NMD) is a host RNA control pathway that removes aberrant transcripts with long 3' untranslated regions (UTRs) due to premature termination codons (PTCs) that arise through mutation or defective splicing.
Jared P May +3 more
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Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP [PDF]
Nature Communications, 2019 The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1.
Manjeera Gowravaram +4 more
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Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism [PDF]
Biomedicines, 2022 Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes.
Fabrice Lejeune
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The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors [PDF]
Nature Communications, 2022 Leukemic stem cells (LSCs) drive chemoresistance and relapse in acute myeloid leukemia. Here, the authors show that the splicing factor RBM17 supports LSCs through avoiding nonsense-mediated decay of pro-leukaemic factors such as the translation ...
Lina Liu +11 more
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Transcriptional robustness complements nonsense-mediated decay in humans. [PDF]
PLoS Genetics, 2011 by a single transcription error. Cusack et al. refer to these codons as fragile. The remaining 43 sense codons are robust. Amino acids can similarly be classified as fragile, robust ,o rfacultative: amino acids that can only be encoded by fragile codons are fragile, amino acids that can only be encoded by robust codons are robust, and amino acids that ...
Claus O Wilke
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Nonsense-mediated mRNA decay among coagulation factor genes [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors.
Shirin Shahbazi
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Escape from nonsense-mediated decay associates with anti-tumor immunogenicity [PDF]
Nature Communications, 2020 The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense mediated decay. Here, the authors show that some of these transcripts can escape this degradation mechanism and their prevalence correlates with tumour ...
Kevin Litchfield +19 more
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