Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay [PDF]
Nature Communications, 2016 Gene expression is regulated by a range of mechanisms, including post-translational modifications such as phosphorylation. Here the authors present evidence for a feedback mechanism whereby hyperphosphorylation of UPF1 in response to delays in nonsense ...
Sébastien Durand +2 more
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Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP [PDF]
Nature Communications, 2019 The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1.
Manjeera Gowravaram +4 more
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Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses. [PDF]
Viruses, 2023 The virus–host interaction is dynamic and evolutionary. Viruses have to fight with hosts to establish successful infection. Eukaryotic hosts are equipped with multiple defenses against incoming viruses.
Ahmed MR, Du Z.
europepmc +2 more sources
Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System. [PDF]
Biomedicines, 2023 Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that degrades mRNAs carrying a premature termination codon. Its inhibition, alone or in combination with other approaches, could be exploited to develop therapies for genetic diseases ...
Carrard J +11 more
europepmc +2 more sources
Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay [PDF]
Viruses, 2017 Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA ((+)RNA) viruses.
Giuseppe Balistreri +2 more
doaj +4 more sources
Human disease-causing mutations result in loss of leiomodin 2 through nonsense-mediated mRNA decay. [PDF]
PLoS GenetThe leiomodin (Lmod) family of actin-binding proteins play a critical role in muscle function, highlighted by the fact that mutations in all three family members (LMOD1-3) result in human myopathies.
Pappas CT +4 more
europepmc +2 more sources
Nonsense-Mediated mRNA Decay Factor Functions in Human Health and Disease. [PDF]
Biomedicines, 2023 Nonsense-mediated mRNA decay (NMD) is a cellular surveillance mechanism that degrades mRNAs with a premature stop codon, avoiding the synthesis of C-terminally truncated proteins. In addition to faulty mRNAs, NMD recognises ~10% of endogenous transcripts
Sun L, Mailliot J, Schaffitzel C.
europepmc +2 more sources
Nonsense-mediated mRNA decay: a key regulatory system engaged in cancer. [PDF]
Cell Commun SignalNonsense-mediated mRNA decay (NMD) is a critical cellular surveillance mechanism that prevents the translation of defective or deleterious proteins. The regulation of NMD, including both its activation and the evasion of its target mRNA, is intricately ...
Pan H +5 more
europepmc +2 more sources
Reduced UPF1 levels in senescence impair nonsense-mediated mRNA decay. [PDF]
Commun BiolCells regulate gene expression through various RNA regulatory mechanisms, and this regulation often becomes less efficient with age, contributing to accelerated aging and various age-related diseases.
Koh D +14 more
europepmc +2 more sources
eLife, 2021 The PI3K-related kinase (PIKK) SMG1 monitors the progression of metazoan nonsense-mediated mRNA decay (NMD) by phosphorylating the RNA helicase UPF1. Previous work has shown that the activity of SMG1 is impaired by small molecule inhibitors, is reduced ...
Lukas M Langer +3 more
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