Results 1 to 10 of about 25,212 (153)

Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism

Biomedicines, 2022
Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes.
Fabrice Lejeune
exaly   +3 more sources

Nonsense-mediated mRNA decay: friend or foe in cancer biology? [PDF]

Cell Communication and Signaling
Nonsense-mediated mRNA decay (NMD) is a highly conserved RNA surveillance mechanism in eukaryotic cells. It plays a key role in safeguarding the accuracy of gene expression by eliminating mRNAs with premature termination codons (PTCs) in the cellular ...
Yuhui Wang, Chenghai He, Chengyan Chen, Xin Ma, Xiyao Gao, Guodong Li, Tangliang Li   +6 more
doaj   +2 more sources

Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System [PDF]

Biomedicines, 2023
Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that degrades mRNAs carrying a premature termination codon. Its inhibition, alone or in combination with other approaches, could be exploited to develop therapies for genetic diseases ...
Julie Carrard, Fiona Ratajczak, Joséphine Elsens, Catherine Leroy, Rebekah Kong, Lucie Geoffroy, Arnaud Comte, Guy Fournet, Benoît Joseph, Xiubin Li, Sylvie Moebs-Sanchez, Fabrice Lejeune   +11 more
doaj   +2 more sources

Nonsense-mediated mRNA decay: a key regulatory system engaged in cancer [PDF]

Cell Communication and Signaling
Nonsense-mediated mRNA decay (NMD) is a critical cellular surveillance mechanism that prevents the translation of defective or deleterious proteins. The regulation of NMD, including both its activation and the evasion of its target mRNA, is intricately ...
Hongyu Pan, Xinyu Wu, Bingshuang Hu, Huihua Xiong, Yao Luo, Jian-Kang Zhou   +5 more
doaj   +2 more sources

Reduced UPF1 levels in senescence impair nonsense-mediated mRNA decay [PDF]

Communications Biology
Cells regulate gene expression through various RNA regulatory mechanisms, and this regulation often becomes less efficient with age, contributing to accelerated aging and various age-related diseases.
Dahyeon Koh, Yebin Lee, Kyuchan Kim, Hyeong Bin Jeon, Chaehwan Oh, Sangik Hwang, Minjung Lim, Kwang-Pyo Lee, Yeonkyoung Park, Yong Ryoul Yang, Yoon Ki Kim, Donghwan Shim, Myriam Gorospe, Ji Heon Noh, Kyoung Mi Kim   +14 more
doaj   +2 more sources

Human disease-causing mutations result in loss of leiomodin 2 through nonsense-mediated mRNA decay. [PDF]

PLoS Genetics
The leiomodin (Lmod) family of actin-binding proteins play a critical role in muscle function, highlighted by the fact that mutations in all three family members (LMOD1-3) result in human myopathies.
Christopher T Pappas, Rachel M Mayfield, Ava E Dickerson, Lei Mi-Mi, Carol C Gregorio   +4 more
doaj   +2 more sources

Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8

eLife, 2021
The PI3K-related kinase (PIKK) SMG1 monitors the progression of metazoan nonsense-mediated mRNA decay (NMD) by phosphorylating the RNA helicase UPF1. Previous work has shown that the activity of SMG1 is impaired by small molecule inhibitors, is reduced ...
Lukas M Langer, Fabien Bonneau, Yair Gat, Elena Conti   +3 more
doaj   +1 more source

Unraveling the influences of sequence and position on yeast uORF activity using massively parallel reporter systems and machine learning

eLife, 2023
Upstream open-reading frames (uORFs) are potent cis-acting regulators of mRNA translation and nonsense-mediated decay (NMD). While both AUG- and non-AUG initiated uORFs are ubiquitous in ribosome profiling studies, few uORFs have been experimentally ...
Gemma E May, Christina Akirtava, Matthew Agar-Johnson, Jelena Micic, John Woolford, Joel McManus   +5 more
doaj   +1 more source

Cellular variability of nonsense-mediated mRNA decay

Nature Communications, 2021
Here the author developed a single-cell reporter system to identify cell-to-cell variability of nonsense-mediated mRNA decay (NMD). This approach provides a sensitive tool to investigate cellular heterogeneity of NMD in various physiological conditions.
Hanae Sato, Robert H. Singer
doaj   +1 more source

RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay

Heliyon, 2023
Background: CFTR nonsense alleles generate negligible CFTR protein due to the nonsense mutation: 1) triggering CFTR mRNA degradation by nonsense-mediated mRNA decay (NMD), and 2) terminating CFTR mRNA translation prematurely.
Amna Siddiqui, Arpit Saxena, Joshua Echols, Viktoria Havasi, Lianwu Fu, Kim M. Keeling   +5 more
doaj   +1 more source