Results 11 to 20 of about 41,960 (230)
Cellular variability of nonsense-mediated mRNA decay [PDF]
Nature Communications, 2021 Here the author developed a single-cell reporter system to identify cell-to-cell variability of nonsense-mediated mRNA decay (NMD). This approach provides a sensitive tool to investigate cellular heterogeneity of NMD in various physiological conditions.
Hanae Sato, Robert H. Singer
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Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism [PDF]
Biomedicines, 2022 Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes.
Fabrice Lejeune
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Nonsense-mediated mRNA decay among coagulation factor genes [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors.
Shirin Shahbazi
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Antisense oligonucleotide–directed inhibition of nonsense-mediated mRNA decay [PDF]
Nature Biotechnology, 2015 Nonsense-mediated mRNA decay (NMD) is a cellular quality-control mechanism that is thought to exacerbate the phenotype of certain pathogenic nonsense mutations by preventing the expression of semi-functional proteins. NMD also limits the efficacy of read-through compound (RTC)-based therapies.
Nomakuchi, Tomoki T. +3 more
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eLife, 2023 Upstream open-reading frames (uORFs) are potent cis-acting regulators of mRNA translation and nonsense-mediated decay (NMD). While both AUG- and non-AUG initiated uORFs are ubiquitous in ribosome profiling studies, few uORFs have been experimentally ...
Gemma E May +5 more
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RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay
Heliyon, 2023 Background: CFTR nonsense alleles generate negligible CFTR protein due to the nonsense mutation: 1) triggering CFTR mRNA degradation by nonsense-mediated mRNA decay (NMD), and 2) terminating CFTR mRNA translation prematurely.
Amna Siddiqui +5 more
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Viral subversion of nonsense-mediated mRNA decay [PDF]
RNA, 2020 Viruses have evolved in tandem with the organisms that they infect. Afflictions of the plant and animal kingdoms with viral infections have forced the host organism to evolve new or exploit existing systems to develop the countermeasures needed to offset viral insults.
Maximilian Wei-Lin Popp +2 more
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Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression. [PDF]
PLoS ONE, 2013 Nonsense suppression therapy is an approach to treat genetic diseases caused by nonsense mutations. This therapeutic strategy pharmacologically suppresses translation termination at Premature Termination Codons (PTCs) in order to restore expression of ...
Kim M Keeling +10 more
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Intracellular calcium regulates nonsense-mediated mRNA decay [PDF]
Nature Medicine, 2014 The nonsense-mediated mRNA decay (NMD) pathway selectively eliminates aberrant transcripts containing premature translation termination codons and regulates the levels of a number of physiological mRNAs. NMD modulates the clinical outcome of a variety of human diseases, including cancer and many genetic disorders, and may represent a target for ...
Nickless, Andrew +6 more
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Nonsense-mediated mRNA decay in mammals [PDF]
Journal of Cell Science, 2005 Nonsense-mediated mRNA decay (NMD) in mammalian cells generally degrades mRNAs that terminate translation more than 50-55 nucleotides upstream of a splicing-generated exon-exon junction (reviewed in [Maquat, 2004a][1]; [Nagy and Maquat, 1998][2]).
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