Results 41 to 50 of about 41,960 (230)
Suppressing nonsense--a surprising function for 5-azacytidine. [PDF]
, 2014 In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but ...
Shao, Ada, Wilkinson, Miles F
core +2 more sources
Nonsense-Mediated mRNA Decay Begins Where Translation Ends [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 Nonsense-mediated mRNA decay (NMD) is arguably the best-studied eukaryotic messenger RNA (mRNA) surveillance pathway, yet fundamental questions concerning the molecular mechanism of target RNA selection remain unsolved. Besides degrading defective mRNAs harboring premature termination codons (PTCs), NMD also targets many mRNAs encoding functional full ...
Evangelos D, Karousis +1 more
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When a ribosome encounters a premature termination codon [PDF]
BMB Reports, 2013 In mammalian cells, aberrant transcripts harboring a prematuretermination codon (PTC) can be generated by abnormal orinefficient biogenesis of mRNAs or by somatic mutation.Truncated polypeptides synthesized from these aberranttranscripts could be toxic ...
Jungwook Hwang, Yoon Ki Kim
doaj +1 more source
A role for AKT1 in nonsense-mediated mRNA decay [PDF]
Nucleic Acids Research, 2021 AbstractNonsense-mediated mRNA decay (NMD) is a highly regulated quality control mechanism through which mRNAs harboring a premature termination codon are degraded. It is also a regulatory pathway for some genes. This mechanism is subject to various levels of regulation, including phosphorylation.
Palma, Martine +7 more
openaire +3 more sources
MicroRNA-mediated repression of nonsense mRNAs
eLife, 2014 Numerous studies have established important roles for microRNAs (miRNAs) in regulating gene expression. Here, we report that miRNAs also serve as a surveillance system to repress the expression of nonsense mRNAs that may produce harmful truncated ...
Ya Zhao +5 more
doaj +1 more source
Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation
Nature Communications, 2020 Nonsense-mediated mRNA decay (NMD) is a translation-coupled process that eliminates mRNAs containing premature translation-termination codons. Here the authors identify a role for the NMD factor UPF1 in protein quality control, whereby truncated ...
Yeonkyoung Park +7 more
doaj +1 more source
A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay. [PDF]
PLoS ONE, 2017 The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs containing premature termination codons, limiting the expression of potentially deleterious truncated proteins.
Stacey L Baker, J Robert Hogg
doaj +1 more source
Aberrant mRNA transcripts and nonsense-mediated decay [PDF]
F1000 Biology Reports, 2009 Nobody's perfect, and even the cell turns out a certain fraction of erroneous mRNA transcripts. One of the key quality control mechanisms put in place to recognize and eliminate these transcripts before they can be translated into faulty proteins is nonsense-mediated decay.
openaire +2 more sources
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]
, 2019 This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A. +6 more
core +1 more source
Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay [PDF]
Annual Review of Genetics, 2013 Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical effector of cellular phenotype, i.e., proteins, tight regulation of both the quality and quantity of mRNA is a prerequisite for effective cellular homeostasis. Here, we review nonsense-
Maximilian Wei-Lin, Popp +1 more
openaire +2 more sources