Reduced expression of UPF1 promotes tumor progression through stabilizing COX-2 mRNA in nasopharyngeal carcinoma [PDF]
Frontiers in ImmunologyBackgroundUPF1 (upframeshift 1) is the core factor in the nonsense-mediated mRNA decay (NMD) pathway. UPF1 is dysregulated in multiple human malignancies and may play a role in cancer progression.
Chun Wu +11 more
doaj +2 more sources
Reduced UPF1 levels in senescence impair nonsense-mediated mRNA decay [PDF]
Communications BiologyCells regulate gene expression through various RNA regulatory mechanisms, and this regulation often becomes less efficient with age, contributing to accelerated aging and various age-related diseases.
Dahyeon Koh +14 more
doaj +4 more sources
Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay [PDF]
Nature CommunicationsMetazoan histone mRNAs are a unique class of mRNAs that lack the poly(A) tail present in all other eukaryotic transcripts. Instead, they end in a conserved stem-loop (SL) structure, necessitating a decay mechanism that is distinct from deadenylation ...
Alexandrina Machado de Amorim +15 more
doaj +2 more sources
The prognostic significance of the NMD core factor UPF1 in low-grade glioma [PDF]
Scientific ReportsLow-grade glioma (LGG) frequently occurring in children and adolescents. Upstream frameshift protein 1 (UPF1) is involved in nonsense-mediated mRNA decay (NMD), in LGG progression and tumor invasion remains unclear.
Shuo Yang +5 more
doaj +2 more sources
UPF1 Inhibits Hepatocellular Carcinoma Growth through DUSP1/p53 Signal Pathway
Biomedicines, 2022 Human hepatocellular carcinoma (HCC) has a high mortality rate because of the dearth of effective treatments. Multiple studies have shown that overexpression of UPF1, a key nonsense-mediated mRNA decay (NMD) factor, reduces HCC growth through various ...
Suman Lee +5 more
doaj +3 more sources
A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner [PDF]
Nucleic Acids Research, 2018 The RNA helicase UPF1 is a key component of the nonsense mediated mRNA decay (NMD) pathway. Previous X-ray crystal structures of UPF1 elucidated the molecular mechanisms of its catalytic activity and regulation.
Fabien Bonneau +2 more
exaly +5 more sources
Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP [PDF]
Nature Communications, 2019 The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1.
Manjeera Gowravaram +4 more
doaj +2 more sources
HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA
Biomolecules, 2015 Unspliced, genomic HIV-1 RNA (vRNA) is a component of several ribonucleoprotein complexes (RNP) during the viral replication cycle. In earlier work, we demonstrated that the host upframeshift protein 1 (UPF1), a key factor in nonsense-mediated mRNA decay
Shringar Rao +2 more
exaly +3 more sources
Trypanosomes lack a canonical EJC but possess an UPF1 dependent NMD-like pathway. [PDF]
PLoS ONEThe exon junction complex (EJC) is a key player in metazoan mRNA quality control and is placed upstream of the exon-exon junction after splicing. Its inner core is composed of Magoh, Y14, eIF4AIII and BTZ and the outer core of proteins involved in mRNA ...
Bernardo Papini Gabiatti +7 more
doaj +2 more sources
Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. [PDF]
, 2016 Many gene expression factors contain repetitive phosphorylation sites for single kinases, but the functional significance is poorly understood. Here we present evidence for hyperphosphorylation as a mechanism allowing UPF1, the central factor in nonsense-
Durand, Sébastien +2 more
core +12 more sources