UPF1 Inhibits Hepatocellular Carcinoma Growth through DUSP1/p53 Signal Pathway
Biomedicines, 2022 Human hepatocellular carcinoma (HCC) has a high mortality rate because of the dearth of effective treatments. Multiple studies have shown that overexpression of UPF1, a key nonsense-mediated mRNA decay (NMD) factor, reduces HCC growth through various ...
Jaemin Jeong +2 more
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Nonsense-Mediated Decay mRNA Quality Control System Is Essential for Root Development and Efficient Root Nodule Symbiosis in Medicago truncatula. [PDF]
Plant Cell EnvironPlant, Cell &Environment, Volume 49, Issue 9, Page 7210-7214, September 2026.
Biró JB +8 more
europepmc +2 more sources
Nonsense-mediated mRNA decay factors target short poly(A)-tailed mRNAs lacking a premature termination codon [PDF]
Nature CommunicationsNonsense-mediated mRNA decay (NMD) is a conserved eukaryotic surveillance pathway known to degrade mRNAs containing premature termination codons (PTCs).
Toni Gouhier +2 more
doaj +2 more sources
Reduced expression of UPF1 promotes tumor progression through stabilizing COX-2 mRNA in nasopharyngeal carcinoma [PDF]
Frontiers in ImmunologyBackgroundUPF1 (upframeshift 1) is the core factor in the nonsense-mediated mRNA decay (NMD) pathway. UPF1 is dysregulated in multiple human malignancies and may play a role in cancer progression.
Chun Wu +11 more
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UPF1—From mRNA Degradation to Human Disorders
Cells, 2023 Up-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react in the event of an incorrect translation mechanism.
Iwona Migdal +2 more
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Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay [PDF]
Nature CommunicationsMetazoan histone mRNAs are a unique class of mRNAs that lack the poly(A) tail present in all other eukaryotic transcripts. Instead, they end in a conserved stem-loop (SL) structure, necessitating a decay mechanism that is distinct from deadenylation ...
Alexandrina Machado de Amorim +15 more
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The prognostic significance of the NMD core factor UPF1 in low-grade glioma [PDF]
Scientific ReportsLow-grade glioma (LGG) frequently occurring in children and adolescents. Upstream frameshift protein 1 (UPF1) is involved in nonsense-mediated mRNA decay (NMD), in LGG progression and tumor invasion remains unclear.
Shuo Yang +5 more
doaj +2 more sources
HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA
Biomolecules, 2015 Unspliced, genomic HIV-1 RNA (vRNA) is a component of several ribonucleoprotein complexes (RNP) during the viral replication cycle. In earlier work, we demonstrated that the host upframeshift protein 1 (UPF1), a key factor in nonsense-mediated mRNA decay
Niels H Gehring +2 more
exaly +3 more sources
Regulation of oncogenic C-terminal truncated p53β protein isoform expression by SRSF3–UPF1 splicing and surveillance axis [PDF]
Cell & BioscienceDysregulated expression of tumor suppressor genes can impair their functions, even promoting oncogenesis. Expression of p53β mRNA can be regulated by alternative splicing and RNA surveillance, otherwise translated to a C-terminal truncated p53 protein ...
Jiwon Jeong +5 more
doaj +2 more sources
Cell ReportsSummary: Nonsense-mediated mRNA decay (NMD) is a conserved RNA surveillance mechanism. Inhibition of NMD leads to increased expression of tumor neoantigens encoded by genes with premature termination codons (PTCs), thereby enhancing tumor immunogenicity.
Guihua Wang, Anyi Liu, Changsheng Huang
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