Results 31 to 40 of about 5,540 (157)
UPF1 shuttles between nucleus and cytoplasm independently of its RNA-binding and ATPase activities. [PDF]
RNAThe ATP-dependent RNA helicase Up-frameshift 1 (UPF1) is an essential protein in mammalian cells and a key factor in nonsense-mediated mRNA decay (NMD), a translation-dependent mRNA surveillance process.
Nasif S +5 more
europepmc +3 more sources
RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent [PDF]
, 2017 The RNA-binding protein, UPF1, is best known for its central role in the nonsense-mediated RNA decay (NMD) pathway. Feng et al. now report a new function for UPF1-it is an E3 ubiquitin ligase that specifically promotes the decay of a key pro-muscle ...
Terra-Dawn M. Plank +3 more
core +1 more source
MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1. [PDF]
PLoS ONE, 2013 We have observed low expression levels of MARVELD1, a novel tumor repressor, in multiple tumors; however, its function in normal cells has not been explored.
Jianran Hu, Yu Li, Ping Li
doaj +1 more source
HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition
Nature Communications, 2018 UPF1 is a central protein in nonsense-mediated mRNA decay (NMD), but contribution of its RNA processivity to NMD is unclear. Here, the authors show how the retroviral Tax protein interacts with and inhibits UPF1, and demonstrate that UPF1’s translocase ...
Francesca Fiorini +7 more
doaj +1 more source
Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells
Nature CommunicationsUPF1 and LIN28A are RNA-binding proteins involved in post-transcriptional regulation and stem cell differentiation. Most studies on UPF1 and LIN28A have focused on the molecular mechanisms of differentiated cells and stem cell differentiation ...
Seungwon Jung +5 more
doaj +1 more source
Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers. [PDF]
PLoS ONE, 2008 Nonsense-mediated mRNA Decay (NMD) degrades mutant mRNAs containing premature termination codon (PTC-mRNAs). Here we evaluate the consequence of NMD activity in colorectal cancers (CRCs) showing microsatellite instability (MSI) whose progression is ...
Jamila El-Bchiri +11 more
doaj +1 more source
PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub
Cancer Science, EarlyView.PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley +1 more source
eLife, 2020 Recognition and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from accumulating non-functional and potentially toxic truncated polypeptides. Targeting of PTC-containing transcripts is mediated
Lucas D Serdar +4 more
doaj +1 more source
MedComm, Volume 7, Issue 10, October 2026.In acute brain injury (TBI/ICH), sympathetic hyperactivity is driven by hypothalamic FTO upregulation. FTO demethylates Trhr, blocking m6A‐YTHDF2‐dependent degradation, which stabilizes Trhr mRNA and increases neuronal sensitivity to TRH. Restoring FTO or Trhr alleviates sympathetic hyperactivity, offering a potential target for managing autonomic ...
Maoxing Fei +7 more
wiley +1 more source
Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs
, 2013 Recruitment of the UPF1 nonsense-mediated mRNA decay (NMD) factor to target mRNAs was initially proposed to occur through interaction with release factors at terminating ribosomes. However, recently emerging evidence points toward translation-independent
Zünd, David +8 more
core +1 more source