Results 31 to 40 of about 8,024 (201)

Retroviral adapters hijack the RNA helicase UPF1 in a CRM1/XPO1-dependent manner and reveal proviral roles of UPF1. [PDF]

Nucleic Acids Res, 2023
AbstractThe hijacking of CRM1 export is an important step of the retroviral replication cycle. Here, we investigated the consequences of this hijacking for the host. During HTLV-1 infection, we identified that this hijacking by the viral protein Rex favours the association between CRM1 and the RNA helicase UPF1, leading to a decreased affinity of UPF1 ...
Prochasson L, Mghezzi-Habellah M, Roisin A, Palma M, Robin JP, de Bossoreille S, Cluet D, Mouelhi M, Decimo D, Desrames A, Chaze T, Matondo M, Dutartre H, Thoulouze MI, Lejeune F, Jalinot P, Rety S, Mocquet V.   +17 more
europepmc   +4 more sources

UPF1 contributes to the maintenance of endometrial cancer stem cell phenotype by stabilizing LINC00963

Cell Death and Disease, 2022
Endometrial cancer stem cells (ECSCs) play a vital role in endometrial cancer (EC) metastasis, relapse, and chemoresistance. However, the molecular mechanisms that sustain ECSCs remain elusive.
Hao Chen, Jian Ma, Fanfei Kong, Ning Song, Cuicui Wang, Xiaoxin Ma   +5 more
doaj   +1 more source

Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. [PDF]

, 2013
One third of inherited genetic diseases are caused by mRNAs harboring premature termination codons as a result of nonsense mutations. These aberrant mRNAs are degraded by the Nonsense-Mediated mRNA Decay (NMD) pathway.
Bracho, Dina P, Cajigas, Iván J, Correa, María E, Estrella, Luis A, González, Carlos I, González-Feliciano, José A, Lasalde, Clarivel, León, Alfredo J, Rivera, Andrea V, Rodríguez-Cruz, Eva N, Vega, Irving E, Wilkinson, Miles F   +11 more
core   +1 more source

UPF1 [PDF]

Nucleus, 2012
The human helicase and ATPase up-frameshift suppressor 1 (UPF1), traditionally known as a major player in several RNA quality control mechanisms, is emerging as a crucial caretaker of the stability of the genome. Work from my laboratory has provided insight into the function of UPF1 during DNA metabolism and has revealed that this versatile enzyme ...
openaire   +2 more sources

Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2011
In Saccharomyces cerevisiae, mRNA transcripts with premature termination codons are targeted for deadenylation independent decapping and 5' to 3' decay in a quality control pathway termed nonsense-mediated decay (NMD).
Kylie D Swisher, Roy Parker
doaj   +1 more source

Full UPF3B function is critical for neuronal differentiation of neural stem cells [PDF]

, 2015
Acknowledgments We thank Fred H Gage (Salk Institute, La Jolla, CA, USA) for HCN-A94 cells and Niels Gehring (University of Cologne, Germany) for constructs.
Alrahbeni, Tahani, Anderson, Jihan, McCaig, Colin, Miedzybrodzka, Zosia, Muller, Berndt, Sartor, Francesca   +5 more
core   +2 more sources

Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation [PDF]

Nature Communications, 2020
AbstractNonsense-mediated mRNA decay (NMD) typifies an mRNA surveillance pathway. Because NMD necessitates a translation event to recognize a premature termination codon on mRNAs, truncated misfolded polypeptides (NMD-polypeptides) could potentially be generated from NMD substrates as byproducts.
Yeonkyoung Park, Joori Park, Hyun Jung Hwang, Byungju Kim, Kwon Jeong, Jeeyoon Chang, Jong-Bong Lee, Yoon Ki Kim   +7 more
openaire   +4 more sources

Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals [PDF]

, 2014
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome-wide RNAi screen in Caenorhabditis elegans that resulted in the identification of five novel NMD ...
Ailion M, Angela Casadio, Brand AH, Claudio R Alonso, Dasa Longman, Javier F Cáceres, Laurent Delavaine, Nele Hug, Raúl Vallejos Baier   +8 more
core   +2 more sources

Functional characterization of Upf1 targets inSchizosaccharomyces pombe [PDF]

RNA Biology, 2013
Nonsense-mediated mRNA decay (NMD) is a highly conserved mechanism of mRNA degradation. NMD eliminates mRNAs containing premature termination codons (PTCs), preventing the production of truncated proteins with possible deleterious effects. However, there is mounting evidence that NMD factors, like Upf1, Upf2 and Upf3, participate in general regulation ...
Matia-González, AM, Hasan, A, Moe, GH, Mata, J, Rodríguez-Gabriel, MA   +4 more
openaire   +4 more sources

Human UPF1 Participates in Small RNA-Induced mRNA Downregulation [PDF]

Molecular and Cellular Biology, 2009
MicroRNAs (miRNAs) are endogenous antisense regulators that trigger endonucleolytic mRNA cleavage, translational repression, and/or mRNA decay. miRNA-mediated gene regulation is important for numerous biological pathways, yet the underlying mechanisms are still under rigorous investigation.
Hua, Jin, Mi Ra, Suh, Jinju, Han, Kyu-Hyeon, Yeom, Yoontae, Lee, Inha, Heo, Minju, Ha, Seogang, Hyun, V Narry, Kim   +8 more
openaire   +2 more sources