Results 21 to 30 of about 8,024 (201)
UPF1 regulates mRNA stability by sensing poorly translated coding sequences
Cell ReportsSummary: Post-transcriptional mRNA regulation shapes gene expression, yet how cis-elements and mRNA translation interface to regulate mRNA stability is poorly understood.
Damir Musaev +7 more
doaj +3 more sources
Technology in Cancer Research & Treatment, 2021 Background : Recently, accumulating evidence confirmed that up-frameshift protein 1 (UPF1) was aberrantly expressed in various cancers. However, the molecular mechanism mediated by UPF1 underlying colorectal carcinogenesis remains unclear.
Binlie Chen BM +5 more
doaj +1 more source
Cell Death and Disease, 2021 UPF1 is proved to dysregulate in multiple tumors and influence carcinogenesis. However, the role of UPF1 in oxaliplatin resistance in colorectal cancer (CRC) remains unknown.
Congcong Zhu +8 more
doaj +1 more source
The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma
eLife, 2021 Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a nonsense-mediated mRNA decay (NMD) factor, in PASC, but ...
Jacob T Polaski +7 more
doaj +1 more source
UPF1 Learns to Relax and Unwind [PDF]
Molecular Cell, 2011 In this issue of Molecular Cell, Chakrabarti et al. (2011) structurally reveal how UPF1, an RNA helicase that plays a central role in nonsense-mediated mRNA decay, is conformationally converted from a largely inactive state to an active state upon UPF2 binding.
Gleghorn, Michael L., Maquat, Lynne E.
openaire +2 more sources
Nuclear accumulation of host transcripts during Zika Virus Infection.
PLoS Pathogens, 2023 Zika virus (ZIKV) infects fetal neural progenitor cells (NPCs) causing severe neurodevelopmental disorders in utero. Multiple pathways involved in normal brain development are dysfunctional in infected NPCs but how ZIKV centrally reprograms these ...
Kristoffer E Leon +16 more
doaj +1 more source
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction
Cell Reports, 2021 Summary: Multiple cellular pathways have been suggested to be altered by the C9orf72 GGGGCC (G4C2) hexanucleotide repeat expansion (HRE), including aspects of RNA regulation such as nonsense-mediated decay (NMD).
Benjamin L. Zaepfel +8 more
doaj +1 more source
UPF1 helicase promotes TSN-mediated miRNA decay [PDF]
Genes & Development, 2017 While microRNAs (miRNAs) regulate the vast majority of protein-encoding transcripts, little is known about how miRNAs themselves are degraded. We recently described Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay (TumiD) as a cellular pathway in which the nuclease TSN promotes the decay of miRNAs that contain CA and/or UA ...
Reyad A. Elbarbary +4 more
openaire +2 more sources
Targeted knock-down of miR21 primary transcripts using snoMEN vectors induces apoptosis in human cancer cell lines [PDF]
, 2015 We have previously reported an antisense technology, 'snoMEN vectors', for targeted knock-down of protein coding mRNAs using human snoRNAs manipulated to contain short regions of sequence complementarity with the mRNA target. Here we characterise the use
A Kozomara +59 more
core +8 more sources
Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay. [PDF]
PLoS Genetics, 2016 Chromatoid bodies (CBs) are spermiogenesis-specific organelles of largely unknown function. CBs harbor various RNA species, RNA-associated proteins and proteins of the tudor domain family like TDRD6, which is required for a proper CB architecture ...
Grigorios Fanourgakis +4 more
doaj +1 more source