Results 21 to 30 of about 5,540 (157)
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction
Cell Reports, 2021 Summary: Multiple cellular pathways have been suggested to be altered by the C9orf72 GGGGCC (G4C2) hexanucleotide repeat expansion (HRE), including aspects of RNA regulation such as nonsense-mediated decay (NMD).
Benjamin L. Zaepfel +8 more
doaj +1 more source
UPF1-host transcript interactions are decreased during ZIKV infection of NPCs.
, 2023 A) irCLIP schematic describing the workflow to obtain sequencing data. After 48 hrs of ZIKV infection, UPF1 and RNA are crosslinked using UV light, followed by UPF1 pulldown and protease degradation to expose the UPF1-bound RNA for sequencing.
David Jimenez-Morales (199277) +16 more
core +1 more source
Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay. [PDF]
PLoS Genetics, 2016 Chromatoid bodies (CBs) are spermiogenesis-specific organelles of largely unknown function. CBs harbor various RNA species, RNA-associated proteins and proteins of the tudor domain family like TDRD6, which is required for a proper CB architecture ...
Grigorios Fanourgakis +4 more
doaj +1 more source
Interaction Between LncRNA and UPF1 in Tumors
Frontiers in Genetics, 2021 Long non-coding RNAs (LncRNAs) can bind to other proteins or RNAs to regulate gene expression, and its role in tumors has been extensively studied. A common RNA binding protein, UPF1, is also a key factor in a variety of RNA decay pathways.
Junjian He +3 more
doaj +1 more source
Cell Death and Disease, 2022 Endometrial cancer stem cells (ECSCs) play a vital role in endometrial cancer (EC) metastasis, relapse, and chemoresistance. However, the molecular mechanisms that sustain ECSCs remain elusive.
Hao Chen +5 more
doaj +1 more source
Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2011 In Saccharomyces cerevisiae, mRNA transcripts with premature termination codons are targeted for deadenylation independent decapping and 5' to 3' decay in a quality control pathway termed nonsense-mediated decay (NMD).
Kylie D Swisher, Roy Parker
doaj +1 more source
Nonsense mutations can increase mRNA levels [PDF]
Biology OpenPrecious O. Owuamalam +2 more
doaj +2 more sources
In Silico Analysis of the Structural and Biochemical Features of the NMD Factor UPF1 in Ustilago maydis. [PDF]
PLoS ONE, 2016 The molecular mechanisms regulating the accuracy of gene expression are still not fully understood. Among these mechanisms, Nonsense-mediated Decay (NMD) is a quality control process that detects post-transcriptionally abnormal transcripts and leads them
Nancy Martínez-Montiel +3 more
doaj +1 more source
eLife, 2019 UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the 3’UTRs of mRNAs that are directed for NMD in the cytoplasm.
Anand K Singh +10 more
doaj +1 more source
A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD [PDF]
, 2014 Eukaryotic mRNAs with premature translation-termination codons (PTCs) are recognized and eliminated by nonsense-mediated mRNA decay (NMD). NMD substrates can be degraded by different routes that all require phosphorylated UPF1 (P-UPF1) as a starting ...
Yamashita, Akio +4 more
core +3 more sources