Results 11 to 20 of about 5,540 (157)
UPF1 RNA Immunoprecipitation from Mini-μ Construct–expressing Cells [PDF]
Bio-Protocol, 2014 UPF1, an RNA helicase and a core factor of nonsense-mediated mRNA decay (NMD), interacts with RNA independently of the sequence context. To investigate the influence of translation on the association of UPF1 with specific reporter transcripts, UPF1 RNA ...
David Zünd, Oliver Mühlemann
doaj +4 more sources
UPF1 plays critical roles in early B cell development [PDF]
Nature CommunicationsThe ATP-dependent RNA helicase UPF1 plays a crucial role in various mRNA degradation pathways, most importantly in nonsense-mediated mRNA decay (NMD). Here, we show that UPF1 is upregulated during the early stages of B cell development and is important ...
Noriki Iwai +6 more
doaj +3 more sources
TGFβ1 Activates Lnc-APUE to Promote Tumor Metastasis via the Alu Element-Driven STAU1-Mediated Decay of CDH1 mRNA. [PDF]
Adv Sci (Weinh)We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Li SY +10 more
europepmc +2 more sources
UPF1-Mediated RNA Decay—Danse Macabre in a Cloud
Biomolecules, 2020 Nonsense-mediated RNA decay (NMD) is the prototype example of a whole family of RNA decay pathways that unfold around a common central effector protein called UPF1.
Gabriele Neu-Yilik
exaly +3 more sources
The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation [PDF]
Nature Communications, 2016 UPF1 is a central Nonsense-mediated mRNA decay—(NMD), a mechanism to degrade mRNAs containing premature translation termination codons-factor—whose phosphorylation is key to triggering NMD. Here the authors show that the DHX34 helicase acts as a scaffold
Roberto Melero +5 more
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Cell Death and Disease, 2021 UPF1 is proved to dysregulate in multiple tumors and influence carcinogenesis. However, the role of UPF1 in oxaliplatin resistance in colorectal cancer (CRC) remains unknown.
Congcong Zhu +8 more
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UPF1: a potential biomarker in human cancers
Frontiers in Bioscience-Landmark, 2021 Recently, Up-frameshift protein 1 (UPF1) is reported to be downregulated in various cancers and its low expression is closely correlated with poor prognosis.
Bin-Lie Chen +3 more
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Technology in Cancer Research & Treatment, 2021 Background : Recently, accumulating evidence confirmed that up-frameshift protein 1 (UPF1) was aberrantly expressed in various cancers. However, the molecular mechanism mediated by UPF1 underlying colorectal carcinogenesis remains unclear.
Binlie Chen BM +5 more
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The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma
eLife, 2021 Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a nonsense-mediated mRNA decay (NMD) factor, in PASC, but ...
Jacob T Polaski +7 more
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Nuclear accumulation of host transcripts during Zika Virus Infection.
PLoS Pathogens, 2023 Zika virus (ZIKV) infects fetal neural progenitor cells (NPCs) causing severe neurodevelopmental disorders in utero. Multiple pathways involved in normal brain development are dysfunctional in infected NPCs but how ZIKV centrally reprograms these ...
Kristoffer E Leon +16 more
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