Results 11 to 20 of about 8,024 (201)
UPF1: a potential biomarker in human cancers [PDF]
Frontiers in Bioscience-Landmark, 2021 Recently, Up-frameshift protein 1 (UPF1) is reported to be downregulated in various cancers and its low expression is closely correlated with poor prognosis.
Bin-Lie Chen +3 more
doaj +3 more sources
Interaction Between LncRNA and UPF1 in Tumors [PDF]
Frontiers in Genetics, 2021 Long non-coding RNAs (LncRNAs) can bind to other proteins or RNAs to regulate gene expression, and its role in tumors has been extensively studied. A common RNA binding protein, UPF1, is also a key factor in a variety of RNA decay pathways.
Junjian He +3 more
doaj +3 more sources
UPF1—From mRNA Degradation to Human Disorders
Cells, 2023 Up-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react in the event of an incorrect translation mechanism.
Jacek Staszewski +4 more
doaj +4 more sources
A Novel UPF1 Variant Associated With a Rare UPF1-Related Neurodevelopmental Disorder. [PDF]
Clin GenetNonsense‐mediated mRNA decay (NMD) plays a crucial role in degrading aberrant transcripts with premature termination codons, and aberrant NMD has been linked to neurodevelopmental disorders (NDD). A key player of NMD is UPF1, which is a helicase. Including the current patient, only four individuals with NDD and UPF1 variants have been reported in the ...
Tümer Z +4 more
europepmc +7 more sources
UPF1 plays critical roles in early B cell development
Nature CommunicationsThe ATP-dependent RNA helicase UPF1 plays a crucial role in various mRNA degradation pathways, most importantly in nonsense-mediated mRNA decay (NMD). Here, we show that UPF1 is upregulated during the early stages of B cell development and is important ...
Noriki Iwai +6 more
doaj +4 more sources
UPF1/SMG7-dependent microRNA-mediated gene regulation [PDF]
Nature Communications, 2019 UPF1 mediates the decay of target mRNA in a 3′ untranslated region (UTR)-length-dependent manner. Here the authors reveal that the 3′UTR-length-dependent regulation of UPF1-dependent mRNA decay occurs through EJC-independent but miRNA-dependent ...
Jungyun Park +5 more
doaj +3 more sources
UPF1-Mediated RNA Decay—Danse Macabre in a Cloud [PDF]
Biomolecules, 2020 Nonsense-mediated RNA decay (NMD) is the prototype example of a whole family of RNA decay pathways that unfold around a common central effector protein called UPF1.
Daria Lavysh, Gabriele Neu-Yilik
doaj +3 more sources
CAPZA1 Suppressed the Progression of Esophageal Squamous Cell Carcinoma by Binding to hnRNP K and PTPB1 to Influence Its mRNA Stability. [PDF]
Cancer MedWe identified a SNP (rs373245753, T>G) in the 3′UTR of the CAPZA1 gene from the dbSNP, this study uncovers a novel molecular mechanism which CAPZA1[T] acts as a tumor suppressor by binding to hnRNP K and PTPB1 to influence its mRNA stability, offering potential implications for therapeutic targeting. These results provide insights into the central role
Kang N +5 more
europepmc +2 more sources
TGFβ1 Activates Lnc-APUE to Promote Tumor Metastasis via the Alu Element-Driven STAU1-Mediated Decay of CDH1 mRNA. [PDF]
Adv Sci (Weinh)We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Li SY +10 more
europepmc +2 more sources
UPF1: From mRNA Surveillance to Protein Quality Control [PDF]
Biomedicines, 2021 Selective recognition and removal of faulty transcripts and misfolded polypeptides are crucial for cell viability. In eukaryotic cells, nonsense-mediated mRNA decay (NMD) constitutes an mRNA surveillance pathway for sensing and degrading aberrant transcripts harboring premature termination codons (PTCs).
Hyun Jung Hwang +2 more
openaire +3 more sources