Results 41 to 50 of about 5,540 (157)
Upf1 Senses 3′UTR Length to Potentiate mRNA Decay [PDF]
, 2010 SummaryThe selective degradation of mRNAs by the nonsense-mediated decay pathway is a quality control process with important consequences for human disease.
Goff, Stephen P. +3 more
core +1 more source
ASN Neuro, 2021 Intracerebral haemorrhage (ICH) is a devastating subtype of stroke with high morbidity and mortality. It has been reported that paeonol (PAN) inhibits the progression of ICH. However, the mechanism by which paeonol mediates the progression of ICH remains
Zheng-Long Jin +6 more
doaj +1 more source
Advanced Science, Volume 13, Issue 49, 3 September 2026.RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao +14 more
wiley +1 more source
Edc3-Upf1 interaction does not promote NMD.
, 2013 Upf1 mutants that disrupt the Upf1-Edc3 interaction (mutants 3, 18, 23, and 24) or the Upf1-Edc3 and Upf1-Upf2 interaction (mutant 27) were assessed for their role in NMD.
Roy Parker (315449) +1 more
core +1 more source
Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay [PDF]
, 2008 SummaryIn mammalian cells, nonsense-mediated mRNA decay (NMD) generally requires that translation terminates sufficiently upstream of a post-splicing exon junction complex (EJC) during a pioneer round of translation. The subsequent binding of Upf1 to the
Isken, Olaf +6 more
core +1 more source
Incomplete Nonsense-Mediated Mrna Decay in Giardia Lamblia
, 2009 Messenger RNAs containing premature translation stop codons are degraded by a nonsense-mediated mRNA decay (NMD) system. The NMD pathway is present in yeast, plants and mammals and is thought to protect cells from production of nonfunctional proteins by ...
陳逸修;蘇立欣;孫錦虹 +1 more
core +1 more source
The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein
mBio, 2018 Zika virus (ZIKV) infection of neural progenitor cells (NPCs) in utero is associated with neurological disorders, such as microcephaly, but a detailed molecular understanding of ZIKV-induced pathogenesis is lacking.
Krystal A. Fontaine +10 more
doaj +1 more source
Advanced Science, Volume 13, Issue 44, 7 August 2026.This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li +4 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 8, August 2026.ABSTRACT Colorectal cancer (CRC) is one of the most common malignancies worldwide. Early and accurate diagnosis remains a clinical priority, yet current biopsy techniques are invasive, spatially limited, and may not capture the molecular heterogeneity of tumors.
Gintautas Saulis +9 more
wiley +1 more source
UPF1 involvement in nuclear functions
, 2012 UPF1 (up-frameshift 1) is a protein conserved in all eukaryotes that is necessary for NMD (nonsense-mediated mRNA decay). UPF1 mainly localizes to the cytoplasm and, via mechanisms that are linked to translation termination but not yet well understood ...
Brogna, Saverio, Varsally, Wazeer
core +1 more source