Results 41 to 50 of about 8,024 (201)

UPF1 adds an m6A feather to its (de)cap

Cell Reports, 2022
The N6-methyladenosine modification (m6A) modulates eukaryotic mRNA decay. In this issue of Cell Reports, Boo et al. describe a mechanism for degradation of m6A-containing mRNAs by 5'-decapping, which occurs through the recruitment of the degradation factor UPF1 via the m6A reader protein YTHDF2.
Michelle R, Gibbs, Guillaume F, Chanfreau   +1 more
openaire   +2 more sources

In Silico Analysis of the Structural and Biochemical Features of the NMD Factor UPF1 in Ustilago maydis. [PDF]

PLoS ONE, 2016
The molecular mechanisms regulating the accuracy of gene expression are still not fully understood. Among these mechanisms, Nonsense-mediated Decay (NMD) is a quality control process that detects post-transcriptionally abnormal transcripts and leads them
Nancy Martínez-Montiel, Laura Morales-Lara, Julio M Hernández-Pérez, Rebeca D Martínez-Contreras   +3 more
doaj   +1 more source

Viruses and the cellular RNA decay machinery. [PDF]

, 2010
The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core   +1 more source

The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci

eLife, 2019
UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the 3’UTRs of mRNAs that are directed for NMD in the cytoplasm.
Anand K Singh, Subhendu Roy Choudhury, Sandip De, Jie Zhang, Stephen Kissane, Vibha Dwivedi, Preethi Ramanathan, Marija Petric, Luisa Orsini, Daniel Hebenstreit, Saverio Brogna   +10 more
doaj   +1 more source

Self Organizing strategies for enhanced ICIC (eICIC) [PDF]

, 2014
Small cells have been identified as an effective solution for coping with the important traffic increase that is expected in the coming years. But this solution is accompanied by additional interference that needs to be mitigated. The enhanced Inter Cell
Altman, Eitan, Altman, Zwi, Tall, Abdoulaye   +2 more
core   +4 more sources

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways [PDF]

, 2016
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and ...
Anink, Jasper J., Aronica, Eleonora, Blokhuis, Anna M., Bozzoni, Irene, Demmers, Jeroen A. A., Den Hertog, Jeroen, DINI MODIGLIANI, Stefano, Fumoto, Katsumi, Groen, Ewout J. N., Koppers, Max, Pasterkamp, R. Jeroen, Snelting, Anne, Sodaar, Peter, van Den Berg, Leonard H., van Den Heuvel, Dianne M. A., van Diggelen, Femke, Veldink, Jan H., Verheijen, Bert M.   +17 more
core   +3 more sources

diPaRIS: Dynamic and Interpretable Protein-RNA Interactions Prediction With U-Shaped Network and Novel Structure Encoding. [PDF]

Adv Sci (Weinh)
This study presents diPaRIS, a deep learning method designed to predict dynamic protein‐ RNA interactions with enhanced accuracy. By integrating RNA structures in vivo through a novel encoding scheme for nucleotide correlations, diPaRIS improves the interpretability of binding motifs and outperforms current state‐of‐the‐art methods across multiple ...
Zhang L, Lu C, Peng X, Guo F, Li H, Wang J.   +5 more
europepmc   +2 more sources

Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]

, 2019
This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A., Di Leonardo A., Lentini L., Melfi R., Pace A., Pibiri I., Tutone M.   +6 more
core   +1 more source

UPF1-like helicase grip on nucleic acids dictates processivity [PDF]

Nature Communications, 2018
AbstractHelicases are molecular engines which translocate along nucleic acids (NA) to unwind double-strands or remodel NA–protein complexes. While they have an essential role in genome structure and expression, the rules dictating their processivity remain elusive.
Kanaan, Joanne, Raj, Saurabh, Decourty, Laurence, Saveanu, Cosmin, Croquette, Vincent, Le Hir, Hervé   +5 more
openaire   +4 more sources

A Upf3b-mutant mouse model with behavioral and neurogenesis defects. [PDF]

, 2018
Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts.
Cook-Andersen, H, Dumdie, J, Espinoza, JL, Gecz, J, Huang, L, Jolly, LA, Jones, SH, Kim, H, Lou, C-H, Phan, MH, Roberts, AJ, Shum, EY, Skarbrevik, DM, Swerdlow, NR, Wilkinson, MF   +14 more
core   +1 more source