Results 61 to 70 of about 5,540 (157)
Circular RNAs–Stress Granule Interplay Drives Aging‐Related Proteostasis Loss
Aging Cell, Volume 25, Issue 7, July 2026.Ribonuclease K (RNASEK) maintains ribostasis by degrading circular RNAs (circRNAs) in young cells, enabling functional stress granules (SG) and proper RNA‐protein metabolism for healthy aging and longevity. In aged cells, reduced RNASEK activity causes circRNA accumulation in SG, disrupting ribostasis and proteostasis, leading to cellular dysfunction ...
José M. Izquierdo
wiley +1 more source
UPF1 helicase promotes TSN-mediated miRNA decay
, 2017 While microRNAs (miRNAs) regulate the vast majority of protein-encoding transcripts, little is known about how miRNAs themselves are degraded. We recently described Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay (TumiD) as a ...
Reyad A. Elbarbary +4 more
core +1 more source
BMC Genomics, 2010 Background In addition to acting as an RNA quality control pathway, nonsense-mediated mRNA decay (NMD) plays roles in regulating normal gene expression.
Zavolan Mihaela +5 more
doaj +1 more source
Yeast Upf1 Associates With RibosomesTranslating mRNA Coding Sequences Upstream of Normal Termination Codons: A Dissertation [PDF]
, 2015 Nonsense-mediated mRNA decay (NMD) specifically targets mRNAs with premature translation termination codons for rapid degradation. NMD is a highly conserved translation-dependent mRNA decay pathway, and its core Upf factors are thought to be recruited to
Min, Ei Ei
core +1 more source
Investigation of the interaction between UPF1 and the THO/TREX complex
, 2016 Up-frameshift 1 (UPF1) is a central factor in nonsense-mediated mRNA decay (NMD), a well-known quality-control pathway that detects and degrades mRNA molecules containing premature termination codons and in doing so prevents the accumulation of ...
Mühlemann, Oliver, Gkratsou, Asimina
core +1 more source
EV‐SPEC: Decoding the Spatial Proteomic Signature of the Extracellular Vesicle Corona
Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.This study introduces ‘EV‑SPEC’, a spatial proteomics method using TurboID fused to the transmembrane protein CD63 to map the protein corona of extracellular vesicles (EVs) without physical isolation. We show that EV‐SPEC identifies the protein‐protein interaction footprint of serum proteins, similar to those typically found on synthetic nanoparticles,
Camille Menaceur Vandenbroucke +2 more
wiley +1 more source
Ribosome-bound Upf1 forms distinct 80S complexes and conducts mRNA surveillance
, 2022 Upf1, Upf2, and Upf3, the central regulators of nonsense-mediated mRNA decay (NMD), appear to exercise their NMD functions while bound to elongating ribosomes, and evidence for this conclusion is particularly compelling for Upf1. Hence, we used selective
Baker, Richard E +4 more
core +1 more source
Characterization of Phosphorylation- and RNA-Dependent UPF1 Interactors by Quantitative Proteomics
, 2016 Human up-frameshift 1 (UPF1) is an ATP-dependent RNA helicase and phosphoprotein implicated in several biological processes but is best known for its key function in nonsense-mediated mRNA decay (NMD).
Oliver Mühlemann (1796659) +3 more
core +2 more sources
The Majority of Yeast UPF1 Co-localizes with Polyribosomes in the Cytoplasm [PDF]
, 1995 In Saccharomyces cerevisiae the UPF1 protein is required for nonsense-mediated mRNA decay, the accelerated turnover of mRNAs containing a nonsense mutation.
Leeds, Peter +3 more
core +1 more source
Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1672-1691, June 2026.The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung +5 more
wiley +1 more source