Results 81 to 90 of about 8,024 (201)

Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability

eLife, 2016
The nonsense-mediated mRNA decay (NMD) pathway functions to degrade both abnormal and wild-type mRNAs. NMD is essential for viability in most organisms, but the molecular basis for this requirement is unknown.
Jonathan O Nelson, Kristin A Moore, Alex Chapin, Julie Hollien, Mark M Metzstein   +4 more
doaj   +1 more source

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo, Zhangxiu Liao, Shuangxia Zhang   +2 more
wiley   +1 more source

RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent [PDF]

BioEssays, 2017
The RNA‐binding protein, UPF1, is best known for its central role in the nonsense‐mediated RNA decay (NMD) pathway. Feng et al. now report a new function for UPF1—it is an E3 ubiquitin ligase that specifically promotes the decay of a key pro‐muscle transcription factor: MYOD.
Plank, Terra‐Dawn M, Wilkinson, Miles F   +1 more
openaire   +4 more sources

Role of UPF1 in lncRNA-HEIH regulation for hepatocellular carcinoma therapy

Experimental and Molecular Medicine
UPF1, a novel posttranscriptional regulator, regulates the abundance of transcripts, including long noncoding RNAs (lncRNAs), and thus plays an important role in cell homeostasis.
Hyunho Cha, Minwoo Kim, Narae Ahn, Seong Dong Jeong, Elizaveta Ignatova, Sung Wook Chi, Hyeon Ho Kim, Jungwook Hwang   +7 more
doaj   +1 more source

DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication [PDF]

, 2007
DNA and histone synthesis are coupled and ongoing replication is required to maintain histone gene expression. Here, we expose S phase–arrested cells to the kinase inhibitors caffeine and LY294002.
Blackburn, J., Feijoo, C., Mueller, B., Smythe, C., Zhao, X.   +4 more
core   +2 more sources

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Xu, Hongxi Wu   +8 more
wiley   +1 more source

Ataluren‐Induced Functional Restoration of Neurofibromin in Fibroblasts From Neurofibromatosis Type 1 Patients With Nonsense Mutations

MedComm, Volume 6, Issue 12, December 2025.
The therapeutic potential of ataluren for NF1 nonsense mutations was assessed by a comprehensive evaluation of the RAS/MEK/ERK pathway activity in 22 NF1NS/+ patient‐derived fibroblasts. The whole‐transcriptomic profiles between ataluren responders and nonresponders, and further analysis and validation revealed novel biomarkers, AMPD3 and TGFBR3, for ...
Soyoung Kim, Hyosang Do, Sun Hee Heo, Minji Kang, Soojin Hwang, Dohyung Kim, Min‐Hoo Chang, Kyung Kim, Beom Hee Lee   +8 more
wiley   +1 more source

Inhibition of Nonsense-Mediated mRNA Decay by Antisense Morpholino Oligonucleotides Restores Functional Expression of hERG Nonsense and Frameshift Mutations in Long-QT Syndrome

, 2010
Mutations in the human ether-a-go-go-related gene (hERG) cause long-QT syndrome type 2 (LQT2). We previously described a homozygous LQT2 nonsense mutation Q1070X in which the mutant mRNA is degraded by nonsense-mediated mRNA decay (NMD) leading to a ...
Bhuiyan, Bhuiyan, Conti, Curran, Dominski, Friedman, Frischmeyer, Gong, Gong, Gritz, Holbrook, Howard, Jearawiriyapaisarn, Kapplinger, Khajavi, Kuzmiak, Le Hir, Le Roy, Linde, Lykke-Andersen, Matthew R. Stump, Millat, Nagy, Napolitano, Nicholson, Qiuming Gong, Sanguinetti, Schwartz, Shimizu, Splawski, Stalder, Tester, Trudeau, Usuki, Wu, Yao, Zhang, Zhengfeng Zhou, Zhou, Zhou   +39 more
core   +1 more source

Neocortical neurogenesis: a proneural gene perspective

The FEBS Journal, Volume 292, Issue 21, Page 5580-5610, November 2025.
The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan, Alexandra Moffat, Pierre Mattar, Carol Schuurmans   +3 more
wiley   +1 more source

Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay

BMC Genomics, 2010
Background In addition to acting as an RNA quality control pathway, nonsense-mediated mRNA decay (NMD) plays roles in regulating normal gene expression.
Zavolan Mihaela, Paul Nicodeme, Tan Lit-Yeen, McGlincy Nicholas J, Lilley Kathryn S, Smith Christopher WJ   +5 more
doaj   +1 more source