Results 81 to 90 of about 5,540 (157)

UPF1/SMG7-dependent microRNA-mediated gene regulation

Nature Communications, 2019
UPF1 mediates the decay of target mRNA in a 3′ untranslated region (UTR)-length-dependent manner. Here the authors reveal that the 3′UTR-length-dependent regulation of UPF1-dependent mRNA decay occurs through EJC-independent but miRNA-dependent ...
Jungyun Park, Jwa-Won Seo, Narae Ahn, Seokju Park, Jungwook Hwang, Jin-Wu Nam   +5 more
doaj   +1 more source

Exploring the roles of UPF1 in mRNA generation [PDF]

The RNA helicase UPF1 is predominantly studied in relation to the cytoplasmic pathways of nonsense-mediated mRNA decay (NMD). However, this investigation focused on its potential nu- clear functionalities, building on recent evidence showing it ...
Dixon, Hannah L.
core   +3 more sources

TOP1α, UPF1, and TTG2 regulate seed size in a parental dosage-dependent manner.

PLoS Biology, 2020
Cues of maternal and paternal origins interact to control seed development, and the underlying molecular mechanisms are still far from clear. Here, we show that TOPOISOMERASE Iα (TOP1α), UP-FRAMESHIFT SUPPRESSOR 1 (UPF1), and TRANSPARENT TESTA GLABRA2 ...
Chengxiang Li, Ximing Gong, Bin Zhang, Zhe Liang, Chui Eng Wong, Benjamin Yen How See, Hao Yu   +6 more
doaj   +1 more source

A Novel UPF1 Variant Associated With a Rare UPF1-Related Neurodevelopmental Disorder

Nonsense-mediated mRNA decay (NMD) plays a crucial role in degrading aberrant transcripts with premature termination codons, with the Up-frameshift (UPF) protein family—UPF1, UPF2, and UPF3A/UPF3B—being vital components of this machinery.
Østergaard, Elsebet, Tümer, Zeynep, Dalsberg, Jonas, Rønde, Gitte, Sørensen, Jesper Kiehn   +4 more
core   +1 more source

Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity [PDF]

, 2015
RNA quality-control pathways get rid of faulty RNAs and therefore must be able to discriminate these RNAs from those that are normal. Here we present evidence that the adenosine triphosphatase (ATPase) cycle of the SF1 helicase Upf1 is required for mRNA ...
Martinez, Fernando J, Lykke-Andersen, Jens, Pratt, Gabriel A, Lee, Suzanne R, Yeo, Gene W   +4 more
core   +1 more source

UPF1-dependent glycolysis driven by LINC00887 facilitates macrophage M2 polarization in clear cell renal cell carcinoma

Frontiers in Immunology
IntroductionLINC00887 plays critical roles in tumor biology, from oncogenesis to metastasis and drug resistance, while the specific mechanism in ccRCC remains unclear.
Jiayue Wu, Jiawen Wang, Jiawen Wang, Jingyu Weng, Rongcheng Lin, Rongcheng Lin, Wanghai Cai, Wanghai Cai, Jiajing Liao, Jiajing Liao, Liefu Ye, Liefu Ye, Youcheng Lin, Youcheng Lin, Jinfeng Wu, Jinfeng Wu   +15 more
doaj   +1 more source

Structure of the Nmd4-Upf1 complex supports conservation of the nonsense-mediated mRNA decay pathway between yeast and humans.

PLoS Biology
The nonsense-mediated mRNA decay (NMD) pathway clears eukaryotic cells of mRNAs containing premature termination codons (PTCs) or normal stop codons located in specific contexts. It therefore plays an important role in gene expression regulation.
Irène Barbarin-Bocahu, Nathalie Ulryck, Amandine Rigobert, Nadia Ruiz Gutierrez, Laurence Decourty, Mouna Raji, Bhumika Garkhal, Hervé Le Hir, Cosmin Saveanu, Marc Graille   +9 more
doaj   +1 more source

Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit

, 2014
The central nonsense-mediated mRNA decay (NMD) regulator, Upf1, selectively targets nonsense-containing mRNAs for rapid degradation. In yeast, Upf1 preferentially associates with mRNAs that are NMD substrates, but the mechanism of its selective retention
Amrani, Nadia, Jacobson, Allan, Min, Ei Ei, He, Feng, Roy, Bijoyita   +4 more
core   +1 more source

Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

Nature Communications, 2019
The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1.
Manjeera Gowravaram, Juliane Schwarz, Sana K. Khilji, Henning Urlaub, Sutapa Chakrabarti   +4 more
doaj   +1 more source

UPF1 P-body localization

, 2008
NMD (nonsense-mediated mRNA decay) is a mechanism that degrades transcripts containing PTCs (premature translation termination codons). NMD is a translation-associated process that is expected to take place throughout the cytoplasm.
Brogna, Saverio, Wen, Jikai, Ramanathan, Preethi   +2 more
core   +1 more source