Results 91 to 100 of about 5,540 (157)

Characterization of the functions of Upf1 in the nucleus of Schizosaccharomyces pombe [PDF]

, 2016
Up-frameshift protein 1 (Upf1) is required for nonsense mediated mRNA decay (NMD) across eukaryotes. It has been reported that Upf1 has also nuclear functions, which are independent of its role in NMD.
Wang, Jianming
core   +2 more sources

Trypanosomes lack a canonical EJC but possess an UPF1 dependent NMD-like pathway.

PLoS ONE
The exon junction complex (EJC) is a key player in metazoan mRNA quality control and is placed upstream of the exon-exon junction after splicing. Its inner core is composed of Magoh, Y14, eIF4AIII and BTZ and the outer core of proteins involved in mRNA ...
Bernardo Papini Gabiatti, Eden Ribeiro Freire, Johanna Odenwald, Janaina de Freitas Nascimento, Fabiola Holetz, Mark Carrington, Susanne Kramer, Martin Zoltner   +7 more
doaj   +1 more source

Advances in molecular function of UPF1 in Cancer

It is known that more than 10% of genetic diseases are caused by a mutation in protein-coding mRNA (premature termination codon; PTC). mRNAs with an early stop codon are degraded by the cellular surveillance process known as nonsense-mediated mRNA decay (
Telkoparan-Akillilar, Pelin, Nuhii, Nexhibe, Chichiarelli, Silvia, TELKOPARAN AKILLILAR, PELİN, Saha, Sarmistha, Hadziselimovic, Rifat, Saso, Luciano, Temaj, Gazmend   +7 more
core   +1 more source

Upf1 and Dcp2 interact in a manner dependent upon Edc3.

, 2013
(A) Upf1 was assessed for its ability to interact by yeast two-hybrid analysis with different domains of Dcp2. (B) The Dcp2-Upf1 interaction was further characterized by yeast two-hybrid analysis at the amino acid level. The structure of S.
Roy Parker (315449), Kylie D. Swisher (340756)   +1 more
core   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Retroviral adapters hijack the RNA helicase UPF1 in a CRM1/XPO1-dependent manner and reveal proviral roles of UPF1

International audienceThe hijacking of CRM1 export is an important step of the retroviral replication cycle. Here, we investigated the consequences of this hijacking for the host.
Rety, Stephane, Mocquet, Vincent, Palma, Martine, Jalinot, Pierre, Chaze, Thibault, Lejeune, Fabrice, Dutartre, Hélène, Mouelhi, Malèke, Mghezzi-Habellah, Makram, Cluet, David, Roisin, Armelle, Thoulouze, Maria-Isabel, Matondo, Mariette, Robin, Jean-Philippe, Decimo, Didier, Prochasson, Léa, de Bossoreille, Stève, Desrames, Alexandra   +17 more
core   +1 more source

The RNA helicase UPF1 couples translation flux to co-translational quality control and cell-cycle progression

, 2023
Ribosome collisions cue the ribosome-associated quality control (RQC) pathway for clearing aberrant translation intermediates while activating the ribotoxic stress response (RSR).
Park, Jumin, Lim, Chunghun, Bang, Hyunwoo, Park, Heeju, Lee, Jongbin, Yu, Youngim, Park, Jongmin, Kim, Yoon Ki   +7 more
core  

Antioxidant Glutathione Analogues UPF1 and UPF17 Modulate the Expression of Enzymes Involved in the Pathophysiology of Chronic Obstructive Pulmonary Disease

Current Issues in Molecular Biology
Increased oxidative stress (OS) and systemic inflammation are key players in the pathophysiology of chronic obstructive pulmonary disease (COPD). We aimed to clarify the effects of synthetic glutathione (GSH) analogue peptides UPF1 and UPF17 on the mRNA ...
Ingrid Oit-Wiscombe, Ursel Soomets, Alan Altraja   +2 more
doaj   +1 more source

CircUGP2 inhibits tumor progression via PI3K/AKT/mTOR signaling through sponging miR-137-3p and interacting with UPF1 in hepatocellular carcinoma

Frontiers in Immunology
BackgroundCircular RNA (circRNA) has been shown to have a pivotal role in the initiation and evolution of multiple tumors, but its function in hepatocellular carcinoma (HCC) requires further elucidation.MethodscircUGP2 (hsa_circ_0001020) was identified ...
Longfei Xie, Longfei Xie, Longfei Xie, Longfei Xie, Suxin Li, Suxin Li, Suxin Li, Suxin Li, Huahu Guo, Huahu Guo, Huahu Guo, Huahu Guo, Wenhui Zhang, Wenhui Zhang, Wenhui Zhang, Wenhui Zhang, Mengjie Shang, Mengjie Shang, Mengjie Shang, Mengjie Shang, Bailin Cheng, Bailin Cheng, Bailin Cheng, Bailin Cheng, Dingyang Li, Dingyang Li, Dingyang Li, Dingyang Li, Luhao Li, Luhao Li, Luhao Li, Luhao Li, Zhaochen Liu, Zhaochen Liu, Zhaochen Liu, Zhaochen Liu, Lin Li, Lin Li, Lin Li, Lin Li, Liang Bao, Liang Bao, Liang Bao, Liang Bao, Kaiwei Tian, Kaiwei Tian, Kaiwei Tian, Kaiwei Tian, Chengxuan Li, Chengxuan Li, Chengxuan Li, Chengxuan Li, Xiaowei Dang, Xiaowei Dang, Xiaowei Dang, Xiaowei Dang   +55 more
doaj   +1 more source

The role of UPF1 cap-independent translation in colorectal cancer

Colorectal cancer (CRC) is one of the deadliest diseases worldwide with projections pointing towards an increase for the next two decades. Translation dysregulation of many genes contributes to CRC development, and here we are studying the role of ...
Lacerda, Rafaela, Sousa, Sofia de, Elias, Adriana, Romão, Luísa, Menezes,Juliane   +4 more
core