Results 71 to 80 of about 5,540 (157)
Advanced Science, Volume 13, Issue 29, 22 May 2026.Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang +14 more
wiley +1 more source
The Edc3-Upf1 interaction is not a negative regulator of NMD.
, 2013 (A) NMD of the PTC-containing galactose-inducible reporter transcript, gal-PGK1c142, was assessed in a upf1Δ upf2Δ double deletion strain containing either empty vector, Upf1 wild-type, Upf1 mutant 3, Upf1 mutant 18, Upf1 mutant 23, Upf1 mutant 24, or ...
Roy Parker (315449) +1 more
core +1 more source
The Plant Journal, Volume 126, Issue 3, May 2026.SUMMARY The increasing global prevalence of droughts due to climate change poses a major threat to food security, necessitating the development of drought‐tolerant crops. To respond appropriately to environmental perturbations, plants undergo widespread transcriptional reprogramming at both the gene expression and splicing levels. Differential splicing
Hasna Khan +3 more
wiley +1 more source
, 2012 A: Upf1 protein structure (2gjk) where all known motifs of the family appear in distinguished colors together with their extensions (in red), one new motif (green, named NEWB) and two more coevolving residues (yellow, named COEVA and COEVB), not know to ...
Linda Dib (124223) +1 more
core +1 more source
Cell Reports, 2014 The mechanisms dictating whether a cell proliferates or differentiates have undergone intense scrutiny, but they remain poorly understood. Here, we report that UPF1, a central component in the nonsense-mediated RNA decay (NMD) pathway, plays a key role ...
Chih H. Lou +6 more
doaj +1 more source
eLife, 2020 PI3K-related kinases (PIKKs) are large Serine/Threonine (Ser/Thr)-protein kinases central to the regulation of many fundamental cellular processes.
Lukas M Langer +3 more
doaj +1 more source
Metamorphosis and lncRNAs: A Close Relationship
genesis, Volume 64, Issue 2, April 2026.ABSTRACT The classical definition of metamorphosis is a post‐embryonic transformation, such as from a tadpole to a froglet. However, recent studies suggest this process occurs to some degree in all vertebrates, as the underlying endocrine and molecular pathways are highly conserved. With the advent of high‐throughput sequencing, transcriptomic data for
H. Herrera‐Orozco +1 more
wiley +1 more source
Toxic mechanisms of amyloid oligomers and therapeutic strategies
Protein Science, Volume 35, Issue 4, April 2026.Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova +2 more
wiley +1 more source
Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability
eLife, 2016 The nonsense-mediated mRNA decay (NMD) pathway functions to degrade both abnormal and wild-type mRNAs. NMD is essential for viability in most organisms, but the molecular basis for this requirement is unknown.
Jonathan O Nelson +4 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So +7 more
wiley +1 more source