Results 51 to 60 of about 5,540 (157)
Liver International, Volume 46, Issue 8, August 2026.ABSTRACT Background and Aims Pathogenic variants in neuroblastoma amplified sequence (NBAS) gene causes infantile liver failure type 2 (IFLS2; MIM 616483), characterised by recurrent episodes of liver failure triggered by febrile infections. The underlying pathophysiological mechanisms remain incompletely understood. With this work we try to shed light
Tian Sun +29 more
wiley +1 more source
Retrovirology, 2018 Background The ability of human immunodeficiency virus type 1 (HIV-1) to form a stable viral reservoir is the major obstacle to an HIV-1 cure and post-transcriptional events contribute to the maintenance of viral latency.
Shringar Rao +4 more
doaj +1 more source
The Plant Journal, Volume 127, Issue 4, August 2026.SUMMARY Alternative splicing (AS) is a common gene regulatory mechanism involving distinct interactions between trans‐acting factors and cis‐regulatory elements on the precursor messenger RNA (pre‐mRNA). In this study, we have functionally characterized the structured motif 45ABC, which is located in the pre‐mRNAs of RNA‐binding protein (RBP) 45 genes ...
Maren Reinhardt +5 more
wiley +1 more source
, 2014 Eukaryotic mRNAs with premature translation-termination codons (PTCs) are recognized and eliminated by nonsense-mediated mRNA decay (NMD). NMD targeted mRNAs can be degraded by different routes that all involve phosphorylated UPF1 (P-UPF1) as a starting ...
Nicholson, Pamela
core +1 more source
Cell Reports, 2014 Nonsense-mediated decay (NMD) is a surveillance mechanism that degrades aberrant mRNAs. A complex comprising SMG1, UPF1, and the translation termination factors eRF1 and eRF3 (SURF) is assembled in the vicinity of a premature termination codon ...
Nele Hug, Javier F. Cáceres
doaj +1 more source
RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator
Cell Death Discovery, 2022 The mechanisms by which the tumor behaviors of hepatocellular carcinoma (HCC) support growth and metastasis remain largely unknown, and it has become increasingly apparent that molecular dysregulation is of considerable importance for cellular signaling ...
Tao Guo +6 more
doaj +1 more source
Role of LncSNHG5 in MAFLD: Mechanisms of Arid1a K391 lactylation and lipid accumulation
Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.1. SNHG5 is significantly upregulated in MAFLD. 2. SNHG5 promotes hepatic lipid accumulation by downregulating MCT1 and regulating intracellular lactate metabolism. 3. SNHG5 drives lactylation of Arid1a at the K391 residue through the P300 and HBO1 acyltransferases. Abstract Introduction Metabolic dysfunction‐associated fatty liver disease (MAFLD) is a
Xinmiao Li +5 more
wiley +1 more source
UPF1: a leader at the end of chromosomes.
, 2012 The human helicase and ATPase up-frameshift suppressor 1 (UPF1), traditionally known as a major player in several RNA quality control mechanisms, is emerging as a crucial caretaker of the stability of the genome.
Azzalin CM
core +1 more source
Role of UPF1 in lncRNA-HEIH regulation for hepatocellular carcinoma therapy
Experimental and Molecular MedicineUPF1, a novel posttranscriptional regulator, regulates the abundance of transcripts, including long noncoding RNAs (lncRNAs), and thus plays an important role in cell homeostasis.
Hyunho Cha +7 more
doaj +1 more source
Disease Models & Mechanisms, 2020 Nonsense-mediated mRNA decay (NMD) targets mRNAs that contain a premature termination codon (PTC) for degradation, preventing their translation. By altering the expression of PTC-containing mRNAs, NMD modulates the inheritance pattern and severity of ...
Josh Echols +6 more
doaj +1 more source