The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation
Nature Communications, 2016 UPF1 is a central Nonsense-mediated mRNA decay—(NMD), a mechanism to degrade mRNAs containing premature translation termination codons-factor—whose phosphorylation is key to triggering NMD. Here the authors show that the DHX34 helicase acts as a scaffold
Roberto Melero +5 more
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The expression of UPF1 is regulated by a cap-independent translation initiation mechanism and a cryptic promoter within its 5’ untranslated region [PDF]
, 2014 Regulation of gene expression occurs at several steps, including translation initiation. Under normal circumstances, translation initiation is mainly cap-dependent; however, several proteins can initiate translation in a cap-independent way, allowing the
Lacerda, Rafaela +3 more
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Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome [PDF]
, 2013 Ubiquitin-dependent proteolysis can initiate at ribosomes for myriad reasons including misfolding of a nascent chain or stalling of the ribosome during translation of mRNA.
Deshaies, Raymond J. +3 more
core +1 more source
Identification of targets of tumor suppressor microRNA-34a using a reporter library system [PDF]
, 2017 miRNAs play critical roles in various biological processes by targeting specific mRNAs. Current approaches to identifying miRNA targets are insufficient for elucidation of a miRNA regulatory network. Here, we created a cell-based screening system using a
Asahara, Hiroshi +8 more
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LncRNA PVT1 aggravates the progression of glioma via downregulating UPF1.
European review for medical and pharmacological sciences, 2019 To uncover the influence of plasmacytoma variant translocation 1 (PVT1) on aggravating the progression of glioma via downregulating UPF1.The relative levels of PVT1 and UPF1 in glioma tissues were determined. PVT1 level in glioma patients in stage I+II and stage III+IV, and either with metastasis or not was examined as well.
Lv, Z.-H., Wang, Z.-Y., Li, Z.-Y.
openaire +2 more sources
PLoS BiologyThe nonsense-mediated mRNA decay (NMD) pathway clears eukaryotic cells of mRNAs containing premature termination codons (PTCs) or normal stop codons located in specific contexts. It therefore plays an important role in gene expression regulation.
Irène Barbarin-Bocahu +9 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2018 Background Accumulating evidence confirm that aberrant microRNAs (miRNAs) expression contributes to hepatocellular carcinoma (HCC) development and progression. Previous study reported that miR-1468 showed an up-regulated tendency and might be a potential
Zhikui Liu +9 more
doaj +1 more source
Experimental evidence on the multibidding mechanism [PDF]
, 2006 Pérez-Castrillo and Wettstein (2002) and Veszteg (2004) propose the use of a multibidding mechanism for situations where agents have to choose a common project. Examples are decisions involving public goods (or public "bads").
Ferenc, Veszteg Róbert +3 more
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A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD [PDF]
, 2017 Eukaryotic mRNAs with premature translation-termination codons (PTCs) are recognized and eliminated by nonsense-mediated mRNA decay (NMD). NMD substrates can be degraded by different routes that all require phosphorylated UPF1 (P-UPF1) as a starting ...
Josi, Christoph +4 more
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Növényi RNS degradációs rendszerek: a nonsense-mediated decay rendszer molekuláris biológiája = RNA degradation systems in plants: the molecular biology of nonsense-mediated decay system [PDF]
, 2010 A program célja a növényi Nonsense-mediated mRNA decay (NMD) rendszer molekuláris biológiájának megismerése volt. Az NMD egy ősi eukarióta minőségbiztosítási rendszer, amely felismeri és lebontja a korai stop kodonokat (PTC) tartalmazó mRNS-eket, ezáltal
Hangyáné Benkovics, Anna +4 more
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