Results 121 to 130 of about 8,024 (201)

Envolvimento da ribonuclease humana Dis3L1 em processos de controlo de qualidade da expressão génica [PDF]

, 2011
Tese de mestrado. Biologia (Biologia Humana e Ambiente). Universidade de Lisboa, Faculdade de Ciências, 2011A expressão génica nos eucariotas envolve um número de etapas interligadas desde a transcrição do material genético até à tradução em proteína ...
Cruz, David João Clara da, 1986, Dias, Deodália Maria Antunes, 1952-, Loison, Luísa Romão, 1963-   +2 more
core  

Analysis of the 5’ untranslated region of human UPF1 mRNA indicates both cryptic promoter and internal ribosome entry site activity [PDF]

, 2014
Apart from its role in nonsense-mediated mRNA decay, a mechanism that promotes rapid degradation of transcripts carrying premature translation termination codons, the human up-frameshift 1 (UPF1) DNA and RNA helicase protein plays a crucial role in ...
Lacerda, Rafaela, Marques-Ramos, Ana, Romão, Luísa, Teixeira, Alexandre   +3 more
core  

A logic for reasoning about upper probabilities

, 2002
We present a propositional logic %which can be used to reason about the uncertainty of events, where the uncertainty is modeled by a set of probability measures assigning an interval of probability to each event.
Halpern, Joseph Y., Pucella, Riccardo
core   +4 more sources

Antioxidant Glutathione Analogues UPF1 and UPF17 Modulate the Expression of Enzymes Involved in the Pathophysiology of Chronic Obstructive Pulmonary Disease

Current Issues in Molecular Biology
Increased oxidative stress (OS) and systemic inflammation are key players in the pathophysiology of chronic obstructive pulmonary disease (COPD). We aimed to clarify the effects of synthetic glutathione (GSH) analogue peptides UPF1 and UPF17 on the mRNA ...
Ingrid Oit-Wiscombe, Ursel Soomets, Alan Altraja   +2 more
doaj   +1 more source

UEG Week 2025 DDM Summit Presentations

United European Gastroenterology Journal, Volume 13, Issue S8, Page S1477-S1538, October 2025.
wiley   +1 more source

Regulation of oncogenic C-terminal truncated p53β protein isoform expression by SRSF3–UPF1 splicing and surveillance axis

Cell & Bioscience
Dysregulated expression of tumor suppressor genes can impair their functions, even promoting oncogenesis. Expression of p53β mRNA can be regulated by alternative splicing and RNA surveillance, otherwise translated to a C-terminal truncated p53 protein ...
Jiwon Jeong, Dawon Hong, Tae Young Park, Jung Hur, Taeyoung Koo, Sunjoo Jeong   +5 more
doaj   +1 more source

Caspases compromise SLU7 and UPF1 stability and NMD activity during hepatocarcinogenesis

JHEP Reports
The homeostasis of the cellular transcriptome depends on transcription and splicing mechanisms. Moreover, the fidelity of gene expression, essential to preserve cellular identity and function is secured by different quality control mechanisms including nonsense-mediated RNA decay (NMD).
Carla Rojo, María Gárate-Rascón, Miriam Recalde, Ane Álava, María Elizalde, María Azkona, Iratxe Aldabe, Elisabet Guruceaga, Amaya López-Pascual, M Ujue Latasa, Bruno Sangro, Maite G. Fernández-Barrena, Matías A. Ávila, María Arechederra, Carmen Berasain   +14 more
openaire   +3 more sources

Transcriptomic screen for DIS3 and DIS3L1 exosome subunits associated functional networks in colorectal cancer [PDF]

, 2015
The final step of cytoplasmic mRNA degradation proceeds in either a 5’-3’ direction, catalyzed by XRN1, or in a 3’-5’ direction catalyzed by the exosome. In yeast, DIS3/Rrp44 protein is the catalytic subunit of the exosome.
Costa, Paulo, Gama-Carvalho, Margarida, Romão, Luísa   +2 more
core  

UPF1 shuttles between nucleus and cytoplasm independently of its RNA-binding and ATPase activities. [PDF]

RNA
Nasif S, Eberle AB, Schranz K, Hadorn R, Chakrabarti S, Mühlemann O.   +5 more
europepmc   +2 more sources

Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells. [PDF]

Nat Cell Biol
Markiewicz-Potoczny M, Lee SY, Chatterjee S, Mabin JW, Zinsser A, Sandhu R, Tricola G, Hogg JR, Lazzerini Denchi E.   +8 more
europepmc   +1 more source