Results 141 to 150 of about 5,540 (157)

Nonsense-mediated decay controls a negative feedback loop in innate immune sensing. [PDF]

open access: yesProc Natl Acad Sci U S A
Boudreault S   +6 more
europepmc   +1 more source

Characterization of Phosphorylation- and RNA-Dependent UPF1 Interactors by Quantitative Proteomics [PDF]

open access: yesJournal of Proteome Research, 2014
Human up-frameshift 1 (UPF1) is an ATP-dependent RNA helicase and phosphoprotein implicated in several biological processes but is best known for its key function in nonsense-mediated mRNA decay (NMD).
Oliver Mühlemann, Angela Bachi
exaly   +2 more sources

UPF1 promotes rapid degradation of m6A-containing RNAs

open access: yesCell Reports, 2022
N-6-methyladenosine (m(6)A) is the most prevalent internal modification in eukaryotic mRNAs and affects RNA processing and metabolism. When YTHDF2, an m(6)A-recognizing protein, binds to m(6)A, it facilitates the destabilization of m(6)A-containing RNAs (
Yoon Ki Kim, Hongseok Ha, Sung Ho Boo
exaly   +2 more sources

Identification and Validation of UPF1 as a Novel Prognostic Biomarker in Renal Clear Cell Carcinoma

open access: yesGenes, 2022
Background: Up frameshift protein 1 (UPF1) is a key component of nonsense-mediated mRNA decay (NMD) of mRNA containing premature termination codons (PTCs). The dysregulation of UPF1 has been reported in various cancers. However, the expression profile of
Zhesheng Wen, LeQi Zhong, Hongmu Li
exaly   +2 more sources
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UPF1 increases amino acid levels and promotes cell proliferation in lung adenocarcinoma via the eIF2α-ATF4 axis

Journal of Zhejiang University: Science B, 2022
Hailong Piao, Chundong Gu
exaly  

UPF1 regulates FOXO1 protein expression by promoting PBK transcription in non-small cell lung cancer

Biochemical and Biophysical Research Communications, 2023
Chundong Gu, Jiao Li
exaly  

The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity

Molecular Cell, 2017
Sujatha Jagannathan, Robert K. Bradley
exaly  

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