Protecting the proteome: Eukaryotic cotranslational quality control pathways. [PDF]
The correct decoding of messenger RNAs (mRNAs) into proteins is an essential cellular task. The translational process is monitored by several quality control (QC) mechanisms that recognize defective translation complexes in which ribosomes are stalled on
Bennett, Eric J, Lykke-Andersen, Jens
core +2 more sources
RNA‐binding proteins orchestrating immunity in plants
SUMMARY RNA‐binding proteins (RBPs) direct the function and fate of RNA throughout the RNA lifecycle and play important roles in plant immunity, orchestrating the post‐transcriptional reprogramming of the transcriptome following induction of plant immune responses, a process that we term ‘RBP‐mediated immunity’. Although the importance of specific RBPs
Marcel Bach‐Pages +4 more
wiley +1 more source
TOP1α, UPF1, and TTG2 regulate seed size in a parental dosage-dependent manner.
Cues of maternal and paternal origins interact to control seed development, and the underlying molecular mechanisms are still far from clear. Here, we show that TOPOISOMERASE Iα (TOP1α), UP-FRAMESHIFT SUPPRESSOR 1 (UPF1), and TRANSPARENT TESTA GLABRA2 ...
Chengxiang Li +6 more
doaj +1 more source
An atlas of chromatoid body components [PDF]
The genome of male germ cells is actively transcribed during spermatogenesis to produce phase-specific protein-coding mRNAs and a considerable amount of different noncoding RNAs. Ribonucleoprotein (RNP) granule-mediated RNA regulation provides a powerful
Chalmel, F. +11 more
core +3 more sources
RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications
RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang +4 more
wiley +1 more source
Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors [PDF]
Nonsense-mediated decay is well known by the lucid definition of being a RNA surveillance mechanism that ensures the speedy degradation of mRNAs containing premature translation termination codons.
Kleinschmidt, Nicole +5 more
core
The salicylic acid dependent and independent effects of NMD in plants [PDF]
In eukaryotes, nonsense-mediated mRNA decay (NMD) targets aberrant and selected non-aberrant mRNAs for destruction. A recent screen for mRNAs showing increased abundance in Arabidopsis NMD-deficient mutants revealed that most are associated with the ...
Ashworth, Mary +4 more
core +1 more source
Conservation of Nonsense-Mediated mRNA Decay Complex Components Throughout Eukaryotic Evolution [PDF]
Nonsense-mediated mRNA decay (NMD) is an essential eukaryotic process regulating transcript quality and abundance, and is involved in diverse processes including brain development and plant defenses.
Causier, B +5 more
core +3 more sources
Experimental Evidence on the Multibidding Mechanism [PDF]
Pérez-Castrillo and Wettstein (2002) and Veszteg (2004) propose the use of a multibidding mechanism for situations where agents have to choose a common project. Examples are decisions involving public goods (or public "bads").
David Perez-Castrillo, Robert F. Veszteg
core
UPF1 alleviates the progression of glioma via targeting lncRNA CYTOR.
To uncover the role of UPF1 in alleviating the progression of glioma via targeting long non-coding RNA (lncRNA) CYTOR and underlying mechanism.A total of 30 glioma tissues surgically resected from glioma patients and 30 brain tissues were collected from brain trauma patients undergoing craniotomy during the same period.
Zou, S.-F. +5 more
openaire +2 more sources

