Results 11 to 20 of about 2,306,587 (203)
The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD) [PDF]
Nucleic Acids Research, 2006 Platelet production is induced by the cytokine thrombopoietin (TPO). It is physiologically critical that TPO expression is tightly regulated, because lack of TPO causes life-threatening thrombocytopenia while an excess of TPO results in thrombocytosis. The plasma concentration of TPO is controlled by a negative feedback loop involving receptor-mediated
Stockklausner, Clemens +6 more
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Nonsense-mediated mRNA decay (NMD) mechanisms
Nature Structural & Molecular Biology, 2009 Nonsense-mediated mRNA decay (NMD) is a translation-coupled mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In mammalian cells, NMD is also linked to pre-mRNA splicing, as in many instances strong mRNA reduction occurs only when the PTC is located upstream of an intron.
Saverio, Brogna, Jikai, Wen
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Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay [PDF]
Viruses, 2017 Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA ((+)RNA) viruses.
Giuseppe Balistreri +2 more
doaj +3 more sources
SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma. [PDF]
Mol Oncol, 2023 Early data suggested that CC‐115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA‐dependent protein kinase (DNA‐PK) may have additional targets beyond TORK and DNA‐PK. Therefore, we aimed to identify such target(s) and investigate a potential therapeutic applicability ...
Leeksma AC +20 more
europepmc +6 more sources
The nonsense-mediated mRNA decay (NMD) pathway differentially regulates COX17, COX19 and COX23 mRNAs. [PDF]
Curr Genet, 2019 The differential regulation of COX17, COX19 and COX23 mRNAs by the nonsense-mediated mRNA decay (NMD) pathway was investigated. The NMD pathway regulates mRNAs that aberrantly terminate translation. This includes mRNAs harboring premature translation termination codons and natural mRNAs.
Murtha K +4 more
europepmc +4 more sources
Environmental stresses suppress nonsense-mediated mRNA decay (NMD) and affect cells by stabilizing NMD-targeted gene expression. [PDF]
Sci Rep, 2019 AbstractNonsense-mediated mRNA decay (NMD) is a cellular mechanism that eliminates mRNAs that harbor premature translation termination codons (PTCs). Here, we investigated the effects of environmental stresses (oxidative stress and endoplasmic reticulum (ER) stress) on NMD activity.
Usuki F, Yamashita A, Fujimura M.
europepmc +4 more sources
Spermatogenesis Studies Reveal a Distinct Nonsense-Mediated mRNA Decay (NMD) Mechanism for mRNAs with Long 3'UTRs. [PDF]
PLoS Genet, 2016 Extensive alternative splicing and polyadenylation of pre-mRNAs not only expands the protein coding potential of our genomes but also generates a wealth of mRNA isoforms with different 3′ untranslated regions (UTRs) [1,2]. Since 3′UTRs are major regulators of mRNA stability, localization, and translation, the tissue-specific, developmentally regulated,
Mühlemann O.
europepmc +6 more sources
, 2013 Nonsense–mediated mRNA Decay (NMD) is a mechanism of translation-dependent mRNA surveillance in eukaryotes: it degrades mRNAs with premature termination codons (PTCs) as well as a number of normal, physiological important mRNAs. In mammals, the degradation of PTC-containing mRNAs is triggered by the exon-junction-complex (EJC) through binding of its ...
Geißler, Verena
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SMG6's PIN (PilT N-Terminus) Domain Is Required for Nonsense-Mediated mRNA Decay (NMD) <i>In Vivo</i>. [PDF]
CellsNonsense-mediated mRNA decay (NMD) is a highly conserved RNA quality and quantity surveillance machinery in eukaryotic cells, serving as an important node in the post-transcriptional gene expression. Previous studies using the complete knockout of individual NMD factors in cells or animals reveal that NMD deficiency causes developmental defects and ...
Chai B, Tan X, Li Y, Chen C, Ma X, Li T.
europepmc +3 more sources
Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question [PDF]
Current Opinion in Genetics & Development, 2011 Nonsense-mediated mRNA decay (NMD) is a well-studied cellular quality-control pathway. It decreases the half-lives of eukaryotic mRNAs that aberrantly contain premature termination codons and additionally regulates an estimated 10-20% of normal transcripts. NMD factors play crucial roles during embryogenesis in many animals.
Jungwook, Hwang, Lynne E, Maquat
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