To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases [PDF]
Trends in Genetics, 2021 The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs bearing premature termination codons (PTCs). Decades of work have elucidated the molecular mechanisms of NMD. More recently, statistical analyses of large genomic datasets have allowed the importance of known and novel 'rules of NMD' to be tested and combined into methods ...
Supek, Fran +2 more
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UPF1 is required for nonsense‐mediated mRNA decay (NMD) and RNAi in Arabidopsis [PDF]
The Plant Journal, 2006 SummaryAberrant mRNAs containing premature termination codons (PTCs) have the potential to be translated into truncated proteins, which could act to the detriment of the organism by interfering with normal cellular processes. Eukaryotes have mechanisms of mRNA quality control that identify PTC‐containing transcripts and target them for destruction, a ...
Luis, Arciga-Reyes +3 more
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The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD). [PDF]
Pathogens, 2020 Before the establishment of an adaptive immune response, retroviruses can be targeted by several cellular host factors at different stages of the viral replication cycle. This intrinsic immunity relies on a large diversity of antiviral processes. In the case of HTLV-1 infection, these active innate host defense mechanisms are debated.
Prochasson L, Jalinot P, Mocquet V.
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SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma. [PDF]
Mol Oncol, 2023 Early data suggested that CC‐115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA‐dependent protein kinase (DNA‐PK) may have additional targets beyond TORK and DNA‐PK. Therefore, we aimed to identify such target(s) and investigate a potential therapeutic applicability ...
Leeksma AC +20 more
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The nonsense-mediated mRNA decay (NMD) pathway differentially regulates COX17, COX19 and COX23 mRNAs. [PDF]
Curr Genet, 2019 The differential regulation of COX17, COX19 and COX23 mRNAs by the nonsense-mediated mRNA decay (NMD) pathway was investigated. The NMD pathway regulates mRNAs that aberrantly terminate translation. This includes mRNAs harboring premature translation termination codons and natural mRNAs.
Murtha K +4 more
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Environmental stresses suppress nonsense-mediated mRNA decay (NMD) and affect cells by stabilizing NMD-targeted gene expression. [PDF]
Sci Rep, 2019 AbstractNonsense-mediated mRNA decay (NMD) is a cellular mechanism that eliminates mRNAs that harbor premature translation termination codons (PTCs). Here, we investigated the effects of environmental stresses (oxidative stress and endoplasmic reticulum (ER) stress) on NMD activity.
Usuki F, Yamashita A, Fujimura M.
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Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors [PDF]
Cellular and Molecular Life Sciences, 2018 Nonsense-mediated decay is well known by the lucid definition of being a RNA surveillance mechanism that ensures the speedy degradation of mRNAs containing premature translation termination codons.
Kleinschmidt, Nicole +5 more
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Spermatogenesis Studies Reveal a Distinct Nonsense-Mediated mRNA Decay (NMD) Mechanism for mRNAs with Long 3'UTRs. [PDF]
PLoS Genet, 2016 Extensive alternative splicing and polyadenylation of pre-mRNAs not only expands the protein coding potential of our genomes but also generates a wealth of mRNA isoforms with different 3′ untranslated regions (UTRs) [1,2]. Since 3′UTRs are major regulators of mRNA stability, localization, and translation, the tissue-specific, developmentally regulated,
Mühlemann O.
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The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD) [PDF]
Nucleic Acids Research, 2006 Platelet production is induced by the cytokine thrombopoietin (TPO). It is physiologically critical that TPO expression is tightly regulated, because lack of TPO causes life-threatening thrombocytopenia while an excess of TPO results in thrombocytosis. The plasma concentration of TPO is controlled by a negative feedback loop involving receptor-mediated
Stockklausner, Clemens +6 more
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Recoding of Nonsense Mutation as a Pharmacological Strategy
Biomedicines, 2023 Approximately 11% of genetic human diseases are caused by nonsense mutations that introduce a premature termination codon (PTC) into the coding sequence. The PTC results in the production of a potentially harmful shortened polypeptide and activation of a
Gazmend Temaj +5 more
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