Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System
Biomedicines, 2023 Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that degrades mRNAs carrying a premature termination codon. Its inhibition, alone or in combination with other approaches, could be exploited to develop therapies for genetic diseases ...
Julie Carrard +11 more
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Nature Communications, 2020 Cellular nonsense-mediated mRNA decay (NMD) has been shown to play a role in defense against RNA viruses. Here, Zhao et al. show that NMD restricts the DNA virus Kaposi sarcoma-associated herpesvirus (KSHV) via targeting both cellular and viral ...
Yang Zhao +5 more
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Nonsense-mediated mRNA decay uses complementary mechanisms to suppress mRNA and protein accumulation
Life Science Alliance, 2022 A reporter system for quantitative measurements of NMD-sensitive mRNA and protein levels in mammalian cells shows that NMD suppresses protein levels to a greater degree than RNA levels. Nonsense-mediated mRNA decay (NMD) is an essential, highly conserved
Dylan B Udy, Robert K Bradley
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Structural insights into nonsense-mediated mRNA decay (NMD) by electron microscopy [PDF]
Current Opinion in Structural Biology, 2013 Nonsense-mediated mRNA decay (NMD) is a pathway that detects and degrades mRNAs containing premature translation termination codons (PTCs). In humans, recognition of these aberrant mRNAs requires an exon-junction-complex (EJC) placed downstream of a PTC and the dynamic interaction of several UPF/SMG proteins, the ribosome and the EJC.
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HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition
Nature Communications, 2018 UPF1 is a central protein in nonsense-mediated mRNA decay (NMD), but contribution of its RNA processivity to NMD is unclear. Here, the authors show how the retroviral Tax protein interacts with and inhibits UPF1, and demonstrate that UPF1’s translocase ...
Francesca Fiorini +7 more
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Nonsense‐mediated mRNA decay (NMD) silences the accumulation of aberrant trypsin proteinase inhibitor mRNA in Nicotiana attenuata [PDF]
The Plant Journal, 2007 SummaryIn eukaryotes, genes carrying premature termination codons (PTCs) are often associated with decreased mRNA levels compared with their counterparts without PTCs. PTC‐harboring mRNA is rapidly degraded through the nonsense‐mediated mRNA decay (NMD) pathway to prevent the accumulation of potentially detrimental truncated proteins.
Wu, J. +3 more
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A Role for Nonsense-Mediated mRNA Decay in Plants: Pathogen Responses Are Induced in Arabidopsis thaliana NMD Mutants [PDF]
PLoS ONE, 2012 Nonsense-mediated mRNA decay (NMD) is a conserved mechanism that targets aberrant mRNAs for destruction. NMD has also been found to regulate the expression of large numbers of genes in diverse organisms, although the biological role for this is unclear and few evolutionarily conserved targets have been identified.
Newbigin, Edward +8 more
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Characterization of nonsense mediated mRNA decay in Schizosaccharomyces pombe [PDF]
, 2010 Nonsense mediated mRNA decay (NMD) is a translation-coupled process that preferentially destroys mRNAs harboring premature translation termination codons (PTCs). In mammalian cells, NMD is linked to pre-mRNA splicing.
Wen, Jikai
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UPF1: From mRNA Surveillance to Protein Quality Control
Biomedicines, 2021 Selective recognition and removal of faulty transcripts and misfolded polypeptides are crucial for cell viability. In eukaryotic cells, nonsense-mediated mRNA decay (NMD) constitutes an mRNA surveillance pathway for sensing and degrading aberrant ...
Hyun Jung Hwang +2 more
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Nonsense-mediated mRNA decay (NMD): a bifunctional mechanism in human physiology and disease [PDF]
, 2020 Publication: Fernandes R, Nogueira G, da Costa PJ, Pinto F, Romão L. Nonsense-Mediated mRNA Decay in Development, Stress and Cancer. Adv Exp Med Biol. 2019;1157:41-83.
Fernandes, Rafael, Romão, Luísa
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