Results 21 to 30 of about 50,057 (258)

Quality and quantity control of gene expression by nonsense-mediated mRNA decay

Nature Reviews Molecular Cell Biology, 2019
Tatsuaki Kurosaki, M. W. Popp, L. Maquat
semanticscholar   +3 more sources

Nonsense-mediated mRNA Decay and Cancer.

Current Opinion in Genetics & Development, 2018
Nonsense-mediated mRNA decay (NMD) is a conserved mRNA surveillance pathway that cells use to ensure the quality of transcripts and to fine-tune transcript abundance. The role of NMD in cancer development is complex. In some cases, tumors have exploited NMD to downregulate gene expression by apparently selecting for mutations causing destruction of key
M. W. Popp, L. Maquat
semanticscholar   +4 more sources

Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8

eLife, 2021
The PI3K-related kinase (PIKK) SMG1 monitors the progression of metazoan nonsense-mediated mRNA decay (NMD) by phosphorylating the RNA helicase UPF1. Previous work has shown that the activity of SMG1 is impaired by small molecule inhibitors, is reduced ...
Lukas M Langer, Fabien Bonneau, Yair Gat, Elena Conti   +3 more
doaj   +1 more source

Unraveling the influences of sequence and position on yeast uORF activity using massively parallel reporter systems and machine learning

eLife, 2023
Upstream open-reading frames (uORFs) are potent cis-acting regulators of mRNA translation and nonsense-mediated decay (NMD). While both AUG- and non-AUG initiated uORFs are ubiquitous in ribosome profiling studies, few uORFs have been experimentally ...
Gemma E May, Christina Akirtava, Matthew Agar-Johnson, Jelena Micic, John Woolford, Joel McManus   +5 more
doaj   +1 more source

Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine.

Cell, 2016
M. W. Popp, L. Maquat
semanticscholar   +3 more sources

RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay

Heliyon, 2023
Background: CFTR nonsense alleles generate negligible CFTR protein due to the nonsense mutation: 1) triggering CFTR mRNA degradation by nonsense-mediated mRNA decay (NMD), and 2) terminating CFTR mRNA translation prematurely.
Amna Siddiqui, Arpit Saxena, Joshua Echols, Viktoria Havasi, Lianwu Fu, Kim M. Keeling   +5 more
doaj   +1 more source

Viral subversion of nonsense-mediated mRNA decay [PDF]

RNA, 2020
Viruses have evolved in tandem with the organisms that they infect. Afflictions of the plant and animal kingdoms with viral infections have forced the host organism to evolve new or exploit existing systems to develop the countermeasures needed to offset viral insults.
Maximilian Wei-Lin Popp, Hana Cho, Lynne E. Maquat   +2 more
openaire   +2 more sources

Intracellular calcium regulates nonsense-mediated mRNA decay [PDF]

Nature Medicine, 2014
The nonsense-mediated mRNA decay (NMD) pathway selectively eliminates aberrant transcripts containing premature translation termination codons and regulates the levels of a number of physiological mRNAs. NMD modulates the clinical outcome of a variety of human diseases, including cancer and many genetic disorders, and may represent a target for ...
Nickless, Andrew, Jackson, Erin, Marasa, Jayne, Nugent, Patrick, Mercer, Robert W., Piwnica-Worms, David, You, Zhongsheng   +6 more
openaire   +2 more sources

Nonsense-mediated mRNA decay in mammals [PDF]

Journal of Cell Science, 2005
Nonsense-mediated mRNA decay (NMD) in mammalian cells generally degrades mRNAs that terminate translation more than 50-55 nucleotides upstream of a splicing-generated exon-exon junction (reviewed in [Maquat, 2004a][1]; [Nagy and Maquat, 1998][2]).
openaire   +4 more sources

To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases.

Trends in Genetics, 2020
The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs bearing premature termination codons (PTCs). Decades of work have elucidated the molecular mechanisms of NMD.
F. Supek, Ben Lehner, Rik G. H. Lindeboom   +2 more
semanticscholar   +1 more source