Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression. [PDF]
PLoS ONE, 2013 Nonsense suppression therapy is an approach to treat genetic diseases caused by nonsense mutations. This therapeutic strategy pharmacologically suppresses translation termination at Premature Termination Codons (PTCs) in order to restore expression of ...
Kim M Keeling +10 more
doaj +4 more sources
Nonsense-mediated mRNA decay, a simplified view of a complex mechanism. [PDF]
BMB Rep, 2023 Nonsense-mediated mRNA decay (NMD) is both a quality control mechanism and a gene regulation pathway. It has been studied for more than 30 years, with an accumulation of many mechanistic details that have often led to debate and hence to different models
Carrard J, Lejeune F.
europepmc +2 more sources
Nonsense-Mediated mRNA Decay Begins Where Translation Ends. [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 Nonsense-mediated mRNA decay (NMD) is arguably the best-studied eukaryotic messenger RNA (mRNA) surveillance pathway, yet fundamental questions concerning the molecular mechanism of target RNA selection remain unsolved.
E. Karousis, O. Mühlemann
semanticscholar +3 more sources
Nonsense-mediated mRNA decay among coagulation factor genes [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors.
Shirin Shahbazi
doaj +3 more sources
The rules and impact of nonsense-mediated mRNA decay in human cancers
Nature Genetics, 2016 Premature termination codons (PTCs) cause a large proportion of inherited human genetic diseases. PTC-containing transcripts can be degraded by an mRNA surveillance pathway termed nonsense-mediated mRNA decay (NMD). However, the efficiency of NMD varies;
Rik G. H. Lindeboom +2 more
semanticscholar +3 more sources
Antisense oligonucleotide–directed inhibition of nonsense-mediated mRNA decay [PDF]
Nature Biotechnology, 2015 Nonsense-mediated mRNA decay (NMD) is a cellular quality-control mechanism that is thought to exacerbate the phenotype of certain pathogenic nonsense mutations by preventing the expression of semi-functional proteins. NMD also limits the efficacy of read-through compound (RTC)-based therapies.
Juergen Scharner +2 more
exaly +3 more sources
Nonsense-mediated mRNA decay: a key regulatory system engaged in cancer [PDF]
Cell Communication and SignalingNonsense-mediated mRNA decay (NMD) is a critical cellular surveillance mechanism that prevents the translation of defective or deleterious proteins. The regulation of NMD, including both its activation and the evasion of its target mRNA, is intricately ...
Hongyu Pan +5 more
doaj +2 more sources
Human disease-causing mutations result in loss of leiomodin 2 through nonsense-mediated mRNA decay. [PDF]
PLoS GeneticsThe leiomodin (Lmod) family of actin-binding proteins play a critical role in muscle function, highlighted by the fact that mutations in all three family members (LMOD1-3) result in human myopathies.
Christopher T Pappas +4 more
doaj +2 more sources
Reduced UPF1 levels in senescence impair nonsense-mediated mRNA decay [PDF]
Communications BiologyCells regulate gene expression through various RNA regulatory mechanisms, and this regulation often becomes less efficient with age, contributing to accelerated aging and various age-related diseases.
Dahyeon Koh +14 more
doaj +2 more sources
Single-Molecule Imaging Uncovers Rules Governing Nonsense-Mediated mRNA Decay
Molecular Cell, 2019 Summary Nonsense-mediated decay (NMD) is a surveillance system that degrades mRNAs containing a premature termination codon (PTC) and plays important roles in protein homeostasis and disease.
Tim A. Hoek +7 more
semanticscholar +3 more sources