Results 11 to 20 of about 218,010 (194)
RNA virus evasion of nonsense-mediated decay.
PLoS Pathogens, 2018 Nonsense-mediated decay (NMD) is a host RNA control pathway that removes aberrant transcripts with long 3' untranslated regions (UTRs) due to premature termination codons (PTCs) that arise through mutation or defective splicing.
Jared P May +3 more
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A Method for Rapid Inducible RNA Decay. [PDF]
Methods Mol BiolModulating RNA decay is a powerful tool to investigate RNA degradation dynamics. Here, we describe a protocol to inducibly recruit protein factors to regulate target RNA metabolism, called Rapid Inducible Decay of RNA (RIDR). RIDR induces fast and synchronous decay of target mRNAs within minutes and enables direct visualization of mRNA decay dynamics ...
Blake LA, Watkins L, Wu B.
europepmc +3 more sources
Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells [PDF]
Frontiers in EndocrinologyIntroductionProinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components.
Seyed M. Ghiasi +12 more
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Nonsense-mediated RNA decay: an emerging modulator of malignancy. [PDF]
Nat Rev Cancer, 2022 Tan K, Stupack DG, Wilkinson MF.
europepmc +2 more sources
SARS-CoV-2 Nsp1 mediated mRNA degradation requires mRNA interaction with the ribosome
RNA Biology, 2023 Nsp1 is a SARS-CoV-2 host shutoff factor that both represses cellular translation and promotes host RNA decay. However, it is unclear how these two activities are connected and interact with normal translation processes.
Soraya I. Shehata, Roy Parker
doaj +1 more source
RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors. [PDF]
PLoS Pathogens, 2018 Exonuclease-mediated RNA decay in plants is known to be involved primarily in endogenous RNA degradation, and several RNA decay components have been suggested to attenuate RNA silencing possibly through competing for RNA substrates.
Fangfang Li, Aiming Wang
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RNA helicases in RNA decay [PDF]
Biochemical Society Transactions, 2018 RNA molecules have the tendency to fold into complex structures or to associate with complementary RNAs that exoribonucleases have difficulties processing or degrading. Therefore, degradosomes in bacteria and organelles as well as exosomes in eukaryotes have teamed-up with RNA helicases.
Khemici, Vanessa, Linder, Patrick
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The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay. [PDF]
PLoS Genetics, 2013 Control of nuclear RNA stability is essential for proper gene expression, but the mechanisms governing RNA degradation in mammalian nuclei are poorly defined.
Stefan M Bresson, Nicholas K Conrad
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RNA uridylation and decay in plants [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2018 RNA uridylation consists of the untemplated addition of uridines at the 3′ extremity of an RNA molecule. RNA uridylation is catalysed by terminal uridylyltransferases (TUTases), which form a subgroup of the terminal nucleotidyltransferase family, to which poly(A) polymerases also belong. The key role of RNA uridylation is to regulate RNA degradation in
Caroline de Almeida +6 more
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RNA decay, evolution, and the testis [PDF]
RNA Biology, 2017 NMD is a highly conserved pathway that degrades specific subsets of RNAs. There is increasing evidence for roles of NMD in development. In this commentary, we focus on spermatogenesis, a process dramatically impeded upon loss or disruption of NMD. NMD requires strict regulation for normal spermatogenesis, as loss of a newly discovered NMD repressor ...
Samantha H, Jones, Miles, Wilkinson
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