Results 41 to 50 of about 218,010 (194)
Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance [PDF]
BMC Genomics, 2015 Histone epigenome data determined by chromatin immunoprecipitation sequencing (ChIP-seq) is used in identifying transcript regions and estimating expression levels. However, this estimation does not always correlate with eventual RNA expression levels measured by RNA sequencing (RNA-seq).
Maekawa, Sho +11 more
openaire +2 more sources
Low-energy neutrino physics and neutrino mass [PDF]
, 1984 Among the principal concerns in neutrino physics today are the questions of whether neutrinos are massive and, if so, whether the neutrinos emitted in a weak decay are pure or mixed quantum states. The concept of mixed neutrinos has been with us for more
Boehm, F., Vogel, P.
core +1 more source
eLife, 2020 Recognition and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from accumulating non-functional and potentially toxic truncated polypeptides. Targeting of PTC-containing transcripts is mediated
Lucas D Serdar +4 more
doaj +1 more source
PLoS Pathogens, 2019 Nuclear RNAs are subject to a number of RNA decay pathways that serve quality control and regulatory functions. As a result, any virus that expresses its genes in the nucleus must have evolved mechanisms that avoid these pathways, but the how viruses ...
Julio C Ruiz +2 more
doaj +1 more source
Complementarity of end regions increases the lifetime of small RNAs in mammalian cells. [PDF]
PLoS ONE, 2012 Two RNAs (4.5SH and 4.5SI) with unknown functions share a number of features: short length (about 100 nt), transcription by RNA polymerase III, predominately nuclear localization, the presence in various tissues, and relatively narrow taxonomic ...
Anastasia P Koval +3 more
doaj +1 more source
eLife, 2017 Nuclear RNA exosomes catalyze a range of RNA processing and decay activities that are coordinated in part by cofactors, including Mpp6, Rrp47, and the Mtr4 RNA helicase.
Elizabeth V Wasmuth +4 more
doaj +1 more source
MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1. [PDF]
PLoS ONE, 2013 We have observed low expression levels of MARVELD1, a novel tumor repressor, in multiple tumors; however, its function in normal cells has not been explored.
Jianran Hu, Yu Li, Ping Li
doaj +1 more source
Impact of nonsense-mediated mRNA decay on the global expression profile of budding yeast. [PDF]
PLoS Genetics, 2006 Nonsense-mediated mRNA decay (NMD) is a eukaryotic mechanism of RNA surveillance that selectively eliminates aberrant transcripts coding for potentially deleterious proteins. NMD also functions in the normal repertoire of gene expression.
Qiaoning Guan +7 more
doaj +1 more source
Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing
Frontiers in Endocrinology, 2021 Mounting evidence suggests a role for alternative splicing (AS) of transcripts in the normal physiology and pathophysiology of the pancreatic β-cell. In the apparent absence of RNA repair systems, RNA decay pathways are likely to play an important role ...
Seyed M. Ghiasi, Guy A. Rutter
doaj +1 more source
Identification of novel post-transcriptional features in olfactory receptor family mRNAs. [PDF]
, 2015 Olfactory receptor (Olfr) genes comprise the largest gene family in mice. Despite their importance in olfaction, how most Olfr mRNAs are regulated remains unexplored.
Espinoza, Josh L +3 more
core +1 more source