Engineered viral RNA decay intermediates to assess XRN1-mediated decay [PDF]
Methods, 2019 Both RNA synthesis and decay must be balanced within a cell to achieve proper gene expression. Additionally, modulation of RNA decay specifically offers the cell an opportunity to rapidly reshape the transcriptome in response to specific stimuli or cues.
Joseph, Russo +4 more
openaire +2 more sources
Extensive reshaping of bacterial operons by programmed mRNA decay. [PDF]
PLoS Genetics, 2018 Bacterial operons synchronize the expression of multiple genes by placing them under the control of a shared promoter. It was previously shown that polycistronic transcripts can undergo differential RNA decay, leaving some genes within the polycistron ...
Daniel Dar, Rotem Sorek
doaj +1 more source
Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure [PDF]
, 2014 BACKGROUND: The compensatory actions of the endogenous natriuretic peptide system require adequate processing of natriuretic peptide pro‐hormones into biologically active, carboxyl‐terminal fragments.
Barton, P +5 more
core +1 more source
Pervasive allele-specific regulation on RNA decay in hybrid mice
Life Science Alliance, 2018 Using a F1 hybrid mouse system, this study globally investigates the effects of cis -regulatory divergence on RNA decay in mammals and reveals the evolutionary roles of RNA decay regulation.
Wei Sun +4 more
doaj +1 more source
Decay of enveloped SARS-CoV-2 and non-enveloped PMMoV RNA in raw sewage from university dormitories
Frontiers in Microbiology, 2023 IntroductionAlthough severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA has been frequently detected in sewage from many university dormitories to inform public health decisions during the COVID-19 pandemic, a clear understanding of SARS ...
Ye Li +19 more
doaj +1 more source
Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease. [PDF]
, 2017 The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism.
Alkallas, Rached +3 more
core +3 more sources
RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent [PDF]
BioEssays, 2017 The RNA‐binding protein, UPF1, is best known for its central role in the nonsense‐mediated RNA decay (NMD) pathway. Feng et al. now report a new function for UPF1—it is an E3 ubiquitin ligase that specifically promotes the decay of a key pro‐muscle transcription factor: MYOD.
Plank, Terra‐Dawn M +1 more
openaire +4 more sources
Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. [PDF]
, 2016 Many gene expression factors contain repetitive phosphorylation sites for single kinases, but the functional significance is poorly understood. Here we present evidence for hyperphosphorylation as a mechanism allowing UPF1, the central factor in nonsense-
Durand, Sébastien +2 more
core +7 more sources
Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]
, 2014 microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei +2 more
core +3 more sources
Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways
Viruses, 2016 To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from ...
Wendy Ullmer, Bert L. Semler
doaj +1 more source